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Atorvastatin activates PPAR-gamma and attenuates the inflammatory response in human monocytes.

Grip, Olof LU ; Janciauskiene, Sabina LU and Lindgren, Stefan LU (2002) In Inflammation Research1995-01-01+01:00 51(2). p.58-62
Abstract
OBJECTIVE: To investigate the ability of statins to activate the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-gamma) in primary human monocytes in culture. MATERIALS AND METHODS: Human peripheral monocytes were incubated with atorvastatin (0.1-10 micromol/1) for up to 24 hours. PPAR-gamma expression was analysed by electrophoretic mobility shift assay. Pro-inflammatory cytokines were measured by enzyme-linked immunosorbent assays, and oxygen consumption was determined polarographically with a Clark-type oxygen electrode. RESULTS: We found that atorvastatin activates PPAR-gamma and inhibits the production of tumour necrosis factor-alpha up to 38% (p < 0.05), monocyte chemoattractant protein-1 up to 85% (p <... (More)
OBJECTIVE: To investigate the ability of statins to activate the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-gamma) in primary human monocytes in culture. MATERIALS AND METHODS: Human peripheral monocytes were incubated with atorvastatin (0.1-10 micromol/1) for up to 24 hours. PPAR-gamma expression was analysed by electrophoretic mobility shift assay. Pro-inflammatory cytokines were measured by enzyme-linked immunosorbent assays, and oxygen consumption was determined polarographically with a Clark-type oxygen electrode. RESULTS: We found that atorvastatin activates PPAR-gamma and inhibits the production of tumour necrosis factor-alpha up to 38% (p < 0.05), monocyte chemoattractant protein-1 up to 85% (p < 0.05), and gelatinase B up to 73% (p < 0.05), in a concentration-dependent manner. Moreover, atorvastatin shows concentration-dependent inhibition of cellular oxygen consumption up to 41%. CONCLUSIONS: These findings contribute to the growing knowledge of the anti-inflammatory effects of statins, and have led us to the suggestion that statins may control inflammatory responses by the regulation of intracellular lipid homeostasis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Inflammation Research1995-01-01+01:00
volume
51
issue
2
pages
58 - 62
publisher
Birkhaüser
external identifiers
  • pmid:11926313
  • wos:000174297500002
ISSN
1420-908X
language
English
LU publication?
yes
id
4ad5522a-38a6-4f0f-821e-75aeffe0acb3 (old id 107319)
alternative location
http://www.springerlink.com/openurl.asp?genre=article&issn=1023-3830&volume=51&issue=2&spage=58
date added to LUP
2007-07-20 15:41:01
date last changed
2016-04-15 19:27:41
@article{4ad5522a-38a6-4f0f-821e-75aeffe0acb3,
  abstract     = {OBJECTIVE: To investigate the ability of statins to activate the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-gamma) in primary human monocytes in culture. MATERIALS AND METHODS: Human peripheral monocytes were incubated with atorvastatin (0.1-10 micromol/1) for up to 24 hours. PPAR-gamma expression was analysed by electrophoretic mobility shift assay. Pro-inflammatory cytokines were measured by enzyme-linked immunosorbent assays, and oxygen consumption was determined polarographically with a Clark-type oxygen electrode. RESULTS: We found that atorvastatin activates PPAR-gamma and inhibits the production of tumour necrosis factor-alpha up to 38% (p &lt; 0.05), monocyte chemoattractant protein-1 up to 85% (p &lt; 0.05), and gelatinase B up to 73% (p &lt; 0.05), in a concentration-dependent manner. Moreover, atorvastatin shows concentration-dependent inhibition of cellular oxygen consumption up to 41%. CONCLUSIONS: These findings contribute to the growing knowledge of the anti-inflammatory effects of statins, and have led us to the suggestion that statins may control inflammatory responses by the regulation of intracellular lipid homeostasis.},
  author       = {Grip, Olof and Janciauskiene, Sabina and Lindgren, Stefan},
  issn         = {1420-908X},
  language     = {eng},
  number       = {2},
  pages        = {58--62},
  publisher    = {Birkhaüser},
  series       = {Inflammation Research1995-01-01+01:00},
  title        = {Atorvastatin activates PPAR-gamma and attenuates the inflammatory response in human monocytes.},
  volume       = {51},
  year         = {2002},
}