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Distribution of mRNA for VIP and PACAP receptors in human cerebral arteries and cranial ganglia.

Knutsson, Mikael and Edvinsson, Lars LU (2002) In NeuroReport 13(4). p.507-509
Abstract
The distribution of mRNA for pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 (PAC1) and vasoactive intestinal polypeptide (VIP) types 1 and 2 (VPAC1 and VPAC2, respectively) receptors was examined by reverse transcriptase polymerase chain reaction (RT-PCR) in human cerebral arteries and in trigeminal, otic, sphenopalatine and superior cervical ganglia. RT-PCR products of the expected sizes were detected in the arteries, in both the presence and absence of endothelium. In the majority (80%) of the trigeminal, otic and superior cervical ganglia, mRNA for all three receptors were found (n = 5). However, in the sphenopalatine ganglion neither VPAC2 nor PAC1 was detected (n = 2). This finding indicates the occurrence of both... (More)
The distribution of mRNA for pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 (PAC1) and vasoactive intestinal polypeptide (VIP) types 1 and 2 (VPAC1 and VPAC2, respectively) receptors was examined by reverse transcriptase polymerase chain reaction (RT-PCR) in human cerebral arteries and in trigeminal, otic, sphenopalatine and superior cervical ganglia. RT-PCR products of the expected sizes were detected in the arteries, in both the presence and absence of endothelium. In the majority (80%) of the trigeminal, otic and superior cervical ganglia, mRNA for all three receptors were found (n = 5). However, in the sphenopalatine ganglion neither VPAC2 nor PAC1 was detected (n = 2). This finding indicates the occurrence of both prejunctional (ganglia) and postjunctional (vessels) location of VIP and PACAP receptors. (Less)
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keywords
RNA, Receptors, Pituitary Hormone : biosynthesis, Pituitary Hormone : genetics, Pituitary Hormone : metabolism, Vasoactive Intestinal Peptide : biosynthesis, Vasoactive Intestinal Peptide : genetics, Vasoactive Intestinal Peptide : metabolism, Superior Cervical Ganglion : metabolism, Support, Non-U.S. Gov't, Trigeminal Ganglion : metabolism, Vascular : metabolism, Human, Messenger : metabolism, Messenger : biosynthesis, Endothelium, Cerebral Arteries : metabolism, Adult
in
NeuroReport
volume
13
issue
4
pages
507 - 509
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000174971300030
  • pmid:11930171
  • scopus:0037171104
ISSN
1473-558X
language
English
LU publication?
yes
id
5b859589-bf39-44ad-8eae-5c68ad8f8e6d (old id 107387)
alternative location
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11930171&dopt=Abstract
date added to LUP
2016-04-01 12:27:20
date last changed
2024-01-08 20:48:29
@article{5b859589-bf39-44ad-8eae-5c68ad8f8e6d,
  abstract     = {{The distribution of mRNA for pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 (PAC1) and vasoactive intestinal polypeptide (VIP) types 1 and 2 (VPAC1 and VPAC2, respectively) receptors was examined by reverse transcriptase polymerase chain reaction (RT-PCR) in human cerebral arteries and in trigeminal, otic, sphenopalatine and superior cervical ganglia. RT-PCR products of the expected sizes were detected in the arteries, in both the presence and absence of endothelium. In the majority (80%) of the trigeminal, otic and superior cervical ganglia, mRNA for all three receptors were found (n = 5). However, in the sphenopalatine ganglion neither VPAC2 nor PAC1 was detected (n = 2). This finding indicates the occurrence of both prejunctional (ganglia) and postjunctional (vessels) location of VIP and PACAP receptors.}},
  author       = {{Knutsson, Mikael and Edvinsson, Lars}},
  issn         = {{1473-558X}},
  keywords     = {{RNA; Receptors; Pituitary Hormone : biosynthesis; Pituitary Hormone : genetics; Pituitary Hormone : metabolism; Vasoactive Intestinal Peptide : biosynthesis; Vasoactive Intestinal Peptide : genetics; Vasoactive Intestinal Peptide : metabolism; Superior Cervical Ganglion : metabolism; Support; Non-U.S. Gov't; Trigeminal Ganglion : metabolism; Vascular : metabolism; Human; Messenger : metabolism; Messenger : biosynthesis; Endothelium; Cerebral Arteries : metabolism; Adult}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{507--509}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{NeuroReport}},
  title        = {{Distribution of mRNA for VIP and PACAP receptors in human cerebral arteries and cranial ganglia.}},
  url          = {{http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11930171&dopt=Abstract}},
  volume       = {{13}},
  year         = {{2002}},
}