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Distribution of mRNA for VIP and PACAP receptors in human cerebral arteries and cranial ganglia.

Knutsson, Mikael and Edvinsson, Lars LU (2002) In NeuroReport 13(4). p.507-509
Abstract
The distribution of mRNA for pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 (PAC1) and vasoactive intestinal polypeptide (VIP) types 1 and 2 (VPAC1 and VPAC2, respectively) receptors was examined by reverse transcriptase polymerase chain reaction (RT-PCR) in human cerebral arteries and in trigeminal, otic, sphenopalatine and superior cervical ganglia. RT-PCR products of the expected sizes were detected in the arteries, in both the presence and absence of endothelium. In the majority (80%) of the trigeminal, otic and superior cervical ganglia, mRNA for all three receptors were found (n = 5). However, in the sphenopalatine ganglion neither VPAC2 nor PAC1 was detected (n = 2). This finding indicates the occurrence of both... (More)
The distribution of mRNA for pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 (PAC1) and vasoactive intestinal polypeptide (VIP) types 1 and 2 (VPAC1 and VPAC2, respectively) receptors was examined by reverse transcriptase polymerase chain reaction (RT-PCR) in human cerebral arteries and in trigeminal, otic, sphenopalatine and superior cervical ganglia. RT-PCR products of the expected sizes were detected in the arteries, in both the presence and absence of endothelium. In the majority (80%) of the trigeminal, otic and superior cervical ganglia, mRNA for all three receptors were found (n = 5). However, in the sphenopalatine ganglion neither VPAC2 nor PAC1 was detected (n = 2). This finding indicates the occurrence of both prejunctional (ganglia) and postjunctional (vessels) location of VIP and PACAP receptors. (Less)
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Contribution to journal
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published
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keywords
RNA, Receptors, Pituitary Hormone : biosynthesis, Pituitary Hormone : genetics, Pituitary Hormone : metabolism, Vasoactive Intestinal Peptide : biosynthesis, Vasoactive Intestinal Peptide : genetics, Vasoactive Intestinal Peptide : metabolism, Superior Cervical Ganglion : metabolism, Support, Non-U.S. Gov't, Trigeminal Ganglion : metabolism, Vascular : metabolism, Human, Messenger : metabolism, Messenger : biosynthesis, Endothelium, Cerebral Arteries : metabolism, Adult
in
NeuroReport
volume
13
issue
4
pages
507 - 509
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000174971300030
  • pmid:11930171
  • scopus:0037171104
ISSN
1473-558X
language
English
LU publication?
yes
id
5b859589-bf39-44ad-8eae-5c68ad8f8e6d (old id 107387)
alternative location
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11930171&dopt=Abstract
date added to LUP
2007-06-29 11:40:43
date last changed
2017-12-10 03:53:36
@article{5b859589-bf39-44ad-8eae-5c68ad8f8e6d,
  abstract     = {The distribution of mRNA for pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 (PAC1) and vasoactive intestinal polypeptide (VIP) types 1 and 2 (VPAC1 and VPAC2, respectively) receptors was examined by reverse transcriptase polymerase chain reaction (RT-PCR) in human cerebral arteries and in trigeminal, otic, sphenopalatine and superior cervical ganglia. RT-PCR products of the expected sizes were detected in the arteries, in both the presence and absence of endothelium. In the majority (80%) of the trigeminal, otic and superior cervical ganglia, mRNA for all three receptors were found (n = 5). However, in the sphenopalatine ganglion neither VPAC2 nor PAC1 was detected (n = 2). This finding indicates the occurrence of both prejunctional (ganglia) and postjunctional (vessels) location of VIP and PACAP receptors.},
  author       = {Knutsson, Mikael and Edvinsson, Lars},
  issn         = {1473-558X},
  keyword      = {RNA,Receptors,Pituitary Hormone : biosynthesis,Pituitary Hormone : genetics,Pituitary Hormone : metabolism,Vasoactive Intestinal Peptide : biosynthesis,Vasoactive Intestinal Peptide : genetics,Vasoactive Intestinal Peptide : metabolism,Superior Cervical Ganglion : metabolism,Support,Non-U.S. Gov't,Trigeminal Ganglion : metabolism,Vascular : metabolism,Human,Messenger : metabolism,Messenger : biosynthesis,Endothelium,Cerebral Arteries : metabolism,Adult},
  language     = {eng},
  number       = {4},
  pages        = {507--509},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {NeuroReport},
  title        = {Distribution of mRNA for VIP and PACAP receptors in human cerebral arteries and cranial ganglia.},
  volume       = {13},
  year         = {2002},
}