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Global and local dispersion of ventricular repolarization: endocardial monophasic action potential mapping in swine and humans by using an electro-anatomical mapping system.

Kongstad Rasmussen, Ole LU ; Yuan, Shiwen LU ; Hertervig, Eva LU ; Holm, Magnus; Grins, Edgars and Olsson, Bertil LU (2002) In Journal of Electrocardiology 35(2). p.159-167
Abstract
This article evaluates whether the global dispersion of ventricular repolarization (DVR) can be estimated from measurements between a few adjacent or remote sites. Monophasic action potentials (MAP) were recorded from 61 +/- 18 left (LV) or right ventricular (RV) sites in 10 pigs and 44 +/- 16 LV, or RV sites in 8 patients by using the CARTO mapping system. MAP duration (MAPd) and end-of-repolarization time were calculated at each site and 13 repolarization maps from pigs and 10 from patients were reconstructed. Global dispersions in MAPd and EOR over the LV or RV were compared with the adjacent DVR among 3 - 7 MAPs in areas > or = 0.7 and < or = 1 cm(2) and with the remote DVRs between 2 MAPs with the greatest activation time... (More)
This article evaluates whether the global dispersion of ventricular repolarization (DVR) can be estimated from measurements between a few adjacent or remote sites. Monophasic action potentials (MAP) were recorded from 61 +/- 18 left (LV) or right ventricular (RV) sites in 10 pigs and 44 +/- 16 LV, or RV sites in 8 patients by using the CARTO mapping system. MAP duration (MAPd) and end-of-repolarization time were calculated at each site and 13 repolarization maps from pigs and 10 from patients were reconstructed. Global dispersions in MAPd and EOR over the LV or RV were compared with the adjacent DVR among 3 - 7 MAPs in areas > or = 0.7 and < or = 1 cm(2) and with the remote DVRs between 2 MAPs with the greatest activation time difference (remote DVR1) and between the apical and laterobasal LV or RV (remote DVR2). The adjacent dispersions in end-of-repolarization and MAPd were significantly smaller than the global ones, 13 +/- 3 and 12 +/- 3 ms vs. 44 +/- 9 and 42 +/- 12 ms in pigs and 13 +/- 7 and 14 +/- 8 ms vs. 72 +/- 24 and 66 +/- 22 ms in patients. The remote DVR1 (30 +/- 8 and 17 +/- 10 ms in pigs and 40 +/- 28 and 28 +/- 17 ms in patients) and remote DVR2 (16 +/- 7 and 11 +/- 10 ms in pigs and 35 +/- 24 and 21 +/- 21 ms in patients) were also significantly smaller than the global DVRs. In conclusion, global DVR is poorly estimated from MAP recordings from a few adjacent or remote sites, suggesting the importance of obtaining global information in evaluating DVR. (Less)
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published
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keywords
Ventricular : surgery, Tachycardia, Ventricular : physiopathology, Swine, Optical Rotatory Dispersion, Cardiovascular, Models, Animal, Human, Middle Age, Heart Ventricle : physiopathology, Heart Ventricle : anatomy & histology, Endocardium : physiopathology, Cardiac, Endocardium : anatomy & histology, Action Potentials : physiology, Adult, Aged, Body Surface Potential Mapping : methods, Catheter Ablation, Comparative Study, Electrophysiologic Techniques
in
Journal of Electrocardiology
volume
35
issue
2
pages
159 - 167
publisher
Elsevier
external identifiers
  • pmid:11953917
  • wos:000175021400011
  • scopus:0036224065
ISSN
1532-8430
DOI
10.1054/jelc.2002.31825
language
English
LU publication?
yes
id
351deead-9bac-4880-95bc-c35383ff9ca0 (old id 107661)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11953917&dopt=Abstract
date added to LUP
2007-07-02 11:16:07
date last changed
2017-01-01 04:38:37
@article{351deead-9bac-4880-95bc-c35383ff9ca0,
  abstract     = {This article evaluates whether the global dispersion of ventricular repolarization (DVR) can be estimated from measurements between a few adjacent or remote sites. Monophasic action potentials (MAP) were recorded from 61 +/- 18 left (LV) or right ventricular (RV) sites in 10 pigs and 44 +/- 16 LV, or RV sites in 8 patients by using the CARTO mapping system. MAP duration (MAPd) and end-of-repolarization time were calculated at each site and 13 repolarization maps from pigs and 10 from patients were reconstructed. Global dispersions in MAPd and EOR over the LV or RV were compared with the adjacent DVR among 3 - 7 MAPs in areas &gt; or = 0.7 and &lt; or = 1 cm(2) and with the remote DVRs between 2 MAPs with the greatest activation time difference (remote DVR1) and between the apical and laterobasal LV or RV (remote DVR2). The adjacent dispersions in end-of-repolarization and MAPd were significantly smaller than the global ones, 13 +/- 3 and 12 +/- 3 ms vs. 44 +/- 9 and 42 +/- 12 ms in pigs and 13 +/- 7 and 14 +/- 8 ms vs. 72 +/- 24 and 66 +/- 22 ms in patients. The remote DVR1 (30 +/- 8 and 17 +/- 10 ms in pigs and 40 +/- 28 and 28 +/- 17 ms in patients) and remote DVR2 (16 +/- 7 and 11 +/- 10 ms in pigs and 35 +/- 24 and 21 +/- 21 ms in patients) were also significantly smaller than the global DVRs. In conclusion, global DVR is poorly estimated from MAP recordings from a few adjacent or remote sites, suggesting the importance of obtaining global information in evaluating DVR.},
  author       = {Kongstad Rasmussen, Ole and Yuan, Shiwen and Hertervig, Eva and Holm, Magnus and Grins, Edgars and Olsson, Bertil},
  issn         = {1532-8430},
  keyword      = {Ventricular : surgery,Tachycardia,Ventricular : physiopathology,Swine,Optical Rotatory Dispersion,Cardiovascular,Models,Animal,Human,Middle Age,Heart Ventricle : physiopathology,Heart Ventricle : anatomy & histology,Endocardium : physiopathology,Cardiac,Endocardium : anatomy & histology,Action Potentials : physiology,Adult,Aged,Body Surface Potential Mapping : methods,Catheter Ablation,Comparative Study,Electrophysiologic Techniques},
  language     = {eng},
  number       = {2},
  pages        = {159--167},
  publisher    = {Elsevier},
  series       = {Journal of Electrocardiology},
  title        = {Global and local dispersion of ventricular repolarization: endocardial monophasic action potential mapping in swine and humans by using an electro-anatomical mapping system.},
  url          = {http://dx.doi.org/10.1054/jelc.2002.31825},
  volume       = {35},
  year         = {2002},
}