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Multivariate analysis of chromosomal imbalances in breast cancer delineates cytogenetic pathways and reveals complex relationships among imbalances.

Höglund, Mattias LU ; Gisselsson Nord, David LU ; Hansen, Gunnar B; Säll, Torbjörn LU and Mitelman, Felix LU (2002) In Cancer Research 62(9). p.2675-2680
Abstract
More than 550 breast adenocarcinomas with clonal chromosomal abnormalities have been reported. Although the aberration pattern is clearly nonrandom, no specific primary or secondary karyotypic abnormality has been identified, and furthermore the chronological order in which the aberrations appear during disease progression is not well known. The high degree of karyotypic complexity in epithelial tumors such as breast cancer is one reason why our understanding of the sequential order of cytogenetic evolution is unclear. To overcome some of these difficulties, we have used several statistical methods that allow identification and interpretation of karyotypic pathways. These methods were applied on 538 breast cancer karyotypes. The... (More)
More than 550 breast adenocarcinomas with clonal chromosomal abnormalities have been reported. Although the aberration pattern is clearly nonrandom, no specific primary or secondary karyotypic abnormality has been identified, and furthermore the chronological order in which the aberrations appear during disease progression is not well known. The high degree of karyotypic complexity in epithelial tumors such as breast cancer is one reason why our understanding of the sequential order of cytogenetic evolution is unclear. To overcome some of these difficulties, we have used several statistical methods that allow identification and interpretation of karyotypic pathways. These methods were applied on 538 breast cancer karyotypes. The distribution of the number of imbalances/tumor showed a monomodal appearance, indicating that one single mode of karyotypic evolution is operating in this tumor type. We show that there exists a temporal order with respect to the appearance of chromosomal imbalances. The imbalances +1pq, 1q-, 3p-, and +7 appear earlier than expected from random events, and two cytogenetic pathways, one initiated by +1q and followed by 11q- and -22, the other initiated by either 3p- or 1q- and followed by 1p-, 3q-, and 6q-, can be discerned. We also show that +7 and +8q behave independently of the other imbalances and cannot, by simple means, be incorporated in the identified pathway scheme. Although the cytogenetic pathways are well separated at earlier stages, they later converge and include a common set of late imbalances. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Breast Neoplasms : genetics, Adenocarcinoma : genetics, Chromosome Aberrations, Human, Multivariate Analysis, Karyotyping
in
Cancer Research
volume
62
issue
9
pages
2675 - 2680
publisher
American Association for Cancer Research Inc.
external identifiers
  • pmid:11980667
  • wos:000175265000037
  • scopus:0036570224
ISSN
1538-7445
language
English
LU publication?
yes
id
859b30ef-e916-441f-afad-768fefc77ee6 (old id 107909)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11980667&dopt=Abstract
http://cancerres.aacrjournals.org/cgi/content/full/62/9/2675
date added to LUP
2007-07-07 08:16:21
date last changed
2017-01-08 04:53:32
@article{859b30ef-e916-441f-afad-768fefc77ee6,
  abstract     = {More than 550 breast adenocarcinomas with clonal chromosomal abnormalities have been reported. Although the aberration pattern is clearly nonrandom, no specific primary or secondary karyotypic abnormality has been identified, and furthermore the chronological order in which the aberrations appear during disease progression is not well known. The high degree of karyotypic complexity in epithelial tumors such as breast cancer is one reason why our understanding of the sequential order of cytogenetic evolution is unclear. To overcome some of these difficulties, we have used several statistical methods that allow identification and interpretation of karyotypic pathways. These methods were applied on 538 breast cancer karyotypes. The distribution of the number of imbalances/tumor showed a monomodal appearance, indicating that one single mode of karyotypic evolution is operating in this tumor type. We show that there exists a temporal order with respect to the appearance of chromosomal imbalances. The imbalances +1pq, 1q-, 3p-, and +7 appear earlier than expected from random events, and two cytogenetic pathways, one initiated by +1q and followed by 11q- and -22, the other initiated by either 3p- or 1q- and followed by 1p-, 3q-, and 6q-, can be discerned. We also show that +7 and +8q behave independently of the other imbalances and cannot, by simple means, be incorporated in the identified pathway scheme. Although the cytogenetic pathways are well separated at earlier stages, they later converge and include a common set of late imbalances.},
  author       = {Höglund, Mattias and Gisselsson Nord, David and Hansen, Gunnar B and Säll, Torbjörn and Mitelman, Felix},
  issn         = {1538-7445},
  keyword      = {Breast Neoplasms : genetics,Adenocarcinoma : genetics,Chromosome Aberrations,Human,Multivariate Analysis,Karyotyping},
  language     = {eng},
  number       = {9},
  pages        = {2675--2680},
  publisher    = {American Association for Cancer Research Inc.},
  series       = {Cancer Research},
  title        = {Multivariate analysis of chromosomal imbalances in breast cancer delineates cytogenetic pathways and reveals complex relationships among imbalances.},
  volume       = {62},
  year         = {2002},
}