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Lung ventilation/perfusion SPECT in the artificially embolized pig.

Bajc, Marika LU ; Bitzén, Ulrika LU ; Olsson, Berit LU ; Perez de Sá, Valéria LU ; Palmer, John LU and Jonson, Björn LU (2002) In Journal of Nuclear Medicine 43(5). p.640-647
Abstract
Planar lung scintigraphy is a standard method used for the diagnosis of lung embolism, but it is hampered by the high incidence of nondiagnostic tests. Ventilation/perfusion SPECT may possibly improve this situation. The objective of this study was to compare planar lung scintigraphy with ventilation/perfusion SPECT using pigs with artificially engendered lung emboli labeled with (201)Tl. METHODS: Sixteen anesthetized pigs were each injected with zero to 4 latex emboli. Cylindric emboli were used in the first 7 pigs and flat 3-tailed emboli were used in the remaining 9 pigs. The pigs spontaneously inhaled 30 MBq (99m)Tc-diethylenetriaminepentaacetic acid aerosol for ventilation scintigraphy. Planar scintigraphy and SPECT were performed... (More)
Planar lung scintigraphy is a standard method used for the diagnosis of lung embolism, but it is hampered by the high incidence of nondiagnostic tests. Ventilation/perfusion SPECT may possibly improve this situation. The objective of this study was to compare planar lung scintigraphy with ventilation/perfusion SPECT using pigs with artificially engendered lung emboli labeled with (201)Tl. METHODS: Sixteen anesthetized pigs were each injected with zero to 4 latex emboli. Cylindric emboli were used in the first 7 pigs and flat 3-tailed emboli were used in the remaining 9 pigs. The pigs spontaneously inhaled 30 MBq (99m)Tc-diethylenetriaminepentaacetic acid aerosol for ventilation scintigraphy. Planar scintigraphy and SPECT were performed using a double-head gamma camera in (99m)Tc and (201)Tl windows. Immediately thereafter, 100 MBq (99m)Tc-labeled macroaggregated albumin were injected intravenously followed by SPECT and, finally, planar scintigraphy. The ventilation background was subtracted from the perfusion tomograms for calculation of a normalized ventilation/perfusion (V/P) quotient image set. RESULTS: The cylindric emboli caused artifacts in the ventilation images; therefore, these were excluded from the final analysis. However, for the planar perfusion images of these pigs, sensitivity and specificity were 71% and 91%, respectively, whereas SPECT yielded 100% for both. For the 3-tailed emboli and ventilation/perfusion images, the sensitivity and specificity were 64% and 79%, respectively, for the planar modality, whereas SPECT yielded values of 91% and 87%, respectively. CONCLUSION: V/P SPECT may improve the diagnostic power of lung scintigraphy. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Pulmonary Circulation, Pulmonary Embolism : radionuclide imaging, Non-U.S. Gov't, Support, Swine, Tomography, Emission-Computed, Single-Photon, X-Ray Computed, Lung : radionuclide imaging, Animal, Disease Models
in
Journal of Nuclear Medicine
volume
43
issue
5
pages
640 - 647
publisher
Society of Nuclear Medicine
external identifiers
  • pmid:11994528
  • wos:000175509400020
  • scopus:0036252199
ISSN
0161-5505
language
English
LU publication?
yes
id
04046c3e-aa7b-427c-883b-4fc70ba9b2a8 (old id 108007)
alternative location
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11994528&dopt=Abstract
date added to LUP
2007-07-17 13:16:11
date last changed
2017-05-07 04:13:19
@article{04046c3e-aa7b-427c-883b-4fc70ba9b2a8,
  abstract     = {Planar lung scintigraphy is a standard method used for the diagnosis of lung embolism, but it is hampered by the high incidence of nondiagnostic tests. Ventilation/perfusion SPECT may possibly improve this situation. The objective of this study was to compare planar lung scintigraphy with ventilation/perfusion SPECT using pigs with artificially engendered lung emboli labeled with (201)Tl. METHODS: Sixteen anesthetized pigs were each injected with zero to 4 latex emboli. Cylindric emboli were used in the first 7 pigs and flat 3-tailed emboli were used in the remaining 9 pigs. The pigs spontaneously inhaled 30 MBq (99m)Tc-diethylenetriaminepentaacetic acid aerosol for ventilation scintigraphy. Planar scintigraphy and SPECT were performed using a double-head gamma camera in (99m)Tc and (201)Tl windows. Immediately thereafter, 100 MBq (99m)Tc-labeled macroaggregated albumin were injected intravenously followed by SPECT and, finally, planar scintigraphy. The ventilation background was subtracted from the perfusion tomograms for calculation of a normalized ventilation/perfusion (V/P) quotient image set. RESULTS: The cylindric emboli caused artifacts in the ventilation images; therefore, these were excluded from the final analysis. However, for the planar perfusion images of these pigs, sensitivity and specificity were 71% and 91%, respectively, whereas SPECT yielded 100% for both. For the 3-tailed emboli and ventilation/perfusion images, the sensitivity and specificity were 64% and 79%, respectively, for the planar modality, whereas SPECT yielded values of 91% and 87%, respectively. CONCLUSION: V/P SPECT may improve the diagnostic power of lung scintigraphy.},
  author       = {Bajc, Marika and Bitzén, Ulrika and Olsson, Berit and Perez de Sá, Valéria and Palmer, John and Jonson, Björn},
  issn         = {0161-5505},
  keyword      = {Pulmonary Circulation,Pulmonary Embolism : radionuclide imaging,Non-U.S. Gov't,Support,Swine,Tomography,Emission-Computed,Single-Photon,X-Ray Computed,Lung : radionuclide imaging,Animal,Disease Models},
  language     = {eng},
  number       = {5},
  pages        = {640--647},
  publisher    = {Society of Nuclear Medicine},
  series       = {Journal of Nuclear Medicine},
  title        = {Lung ventilation/perfusion SPECT in the artificially embolized pig.},
  volume       = {43},
  year         = {2002},
}