Lung ventilation/perfusion SPECT in the artificially embolized pig.
(2002) In Journal of Nuclear Medicine 43(5). p.640-647- Abstract
- Planar lung scintigraphy is a standard method used for the diagnosis of lung embolism, but it is hampered by the high incidence of nondiagnostic tests. Ventilation/perfusion SPECT may possibly improve this situation. The objective of this study was to compare planar lung scintigraphy with ventilation/perfusion SPECT using pigs with artificially engendered lung emboli labeled with (201)Tl. METHODS: Sixteen anesthetized pigs were each injected with zero to 4 latex emboli. Cylindric emboli were used in the first 7 pigs and flat 3-tailed emboli were used in the remaining 9 pigs. The pigs spontaneously inhaled 30 MBq (99m)Tc-diethylenetriaminepentaacetic acid aerosol for ventilation scintigraphy. Planar scintigraphy and SPECT were performed... (More)
- Planar lung scintigraphy is a standard method used for the diagnosis of lung embolism, but it is hampered by the high incidence of nondiagnostic tests. Ventilation/perfusion SPECT may possibly improve this situation. The objective of this study was to compare planar lung scintigraphy with ventilation/perfusion SPECT using pigs with artificially engendered lung emboli labeled with (201)Tl. METHODS: Sixteen anesthetized pigs were each injected with zero to 4 latex emboli. Cylindric emboli were used in the first 7 pigs and flat 3-tailed emboli were used in the remaining 9 pigs. The pigs spontaneously inhaled 30 MBq (99m)Tc-diethylenetriaminepentaacetic acid aerosol for ventilation scintigraphy. Planar scintigraphy and SPECT were performed using a double-head gamma camera in (99m)Tc and (201)Tl windows. Immediately thereafter, 100 MBq (99m)Tc-labeled macroaggregated albumin were injected intravenously followed by SPECT and, finally, planar scintigraphy. The ventilation background was subtracted from the perfusion tomograms for calculation of a normalized ventilation/perfusion (V/P) quotient image set. RESULTS: The cylindric emboli caused artifacts in the ventilation images; therefore, these were excluded from the final analysis. However, for the planar perfusion images of these pigs, sensitivity and specificity were 71% and 91%, respectively, whereas SPECT yielded 100% for both. For the 3-tailed emboli and ventilation/perfusion images, the sensitivity and specificity were 64% and 79%, respectively, for the planar modality, whereas SPECT yielded values of 91% and 87%, respectively. CONCLUSION: V/P SPECT may improve the diagnostic power of lung scintigraphy. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/108007
- author
- Bajc, Marika LU ; Bitzén, Ulrika LU ; Olsson, Berit LU ; Perez de Sá, Valéria LU ; Palmer, John LU and Jonson, Björn LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Pulmonary Circulation, Pulmonary Embolism : radionuclide imaging, Non-U.S. Gov't, Support, Swine, Tomography, Emission-Computed, Single-Photon, X-Ray Computed, Lung : radionuclide imaging, Animal, Disease Models
- in
- Journal of Nuclear Medicine
- volume
- 43
- issue
- 5
- pages
- 640 - 647
- publisher
- Society of Nuclear Medicine
- external identifiers
-
- pmid:11994528
- wos:000175509400020
- scopus:0036252199
- ISSN
- 0161-5505
- language
- English
- LU publication?
- yes
- id
- 04046c3e-aa7b-427c-883b-4fc70ba9b2a8 (old id 108007)
- alternative location
- http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11994528&dopt=Abstract
- date added to LUP
- 2016-04-01 15:54:46
- date last changed
- 2022-01-28 08:00:32
@article{04046c3e-aa7b-427c-883b-4fc70ba9b2a8,
abstract = {{Planar lung scintigraphy is a standard method used for the diagnosis of lung embolism, but it is hampered by the high incidence of nondiagnostic tests. Ventilation/perfusion SPECT may possibly improve this situation. The objective of this study was to compare planar lung scintigraphy with ventilation/perfusion SPECT using pigs with artificially engendered lung emboli labeled with (201)Tl. METHODS: Sixteen anesthetized pigs were each injected with zero to 4 latex emboli. Cylindric emboli were used in the first 7 pigs and flat 3-tailed emboli were used in the remaining 9 pigs. The pigs spontaneously inhaled 30 MBq (99m)Tc-diethylenetriaminepentaacetic acid aerosol for ventilation scintigraphy. Planar scintigraphy and SPECT were performed using a double-head gamma camera in (99m)Tc and (201)Tl windows. Immediately thereafter, 100 MBq (99m)Tc-labeled macroaggregated albumin were injected intravenously followed by SPECT and, finally, planar scintigraphy. The ventilation background was subtracted from the perfusion tomograms for calculation of a normalized ventilation/perfusion (V/P) quotient image set. RESULTS: The cylindric emboli caused artifacts in the ventilation images; therefore, these were excluded from the final analysis. However, for the planar perfusion images of these pigs, sensitivity and specificity were 71% and 91%, respectively, whereas SPECT yielded 100% for both. For the 3-tailed emboli and ventilation/perfusion images, the sensitivity and specificity were 64% and 79%, respectively, for the planar modality, whereas SPECT yielded values of 91% and 87%, respectively. CONCLUSION: V/P SPECT may improve the diagnostic power of lung scintigraphy.}},
author = {{Bajc, Marika and Bitzén, Ulrika and Olsson, Berit and Perez de Sá, Valéria and Palmer, John and Jonson, Björn}},
issn = {{0161-5505}},
keywords = {{Pulmonary Circulation; Pulmonary Embolism : radionuclide imaging; Non-U.S. Gov't; Support; Swine; Tomography; Emission-Computed; Single-Photon; X-Ray Computed; Lung : radionuclide imaging; Animal; Disease Models}},
language = {{eng}},
number = {{5}},
pages = {{640--647}},
publisher = {{Society of Nuclear Medicine}},
series = {{Journal of Nuclear Medicine}},
title = {{Lung ventilation/perfusion SPECT in the artificially embolized pig.}},
url = {{http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11994528&dopt=Abstract}},
volume = {{43}},
year = {{2002}},
}