Advanced

The redox state of glutathione, cysteine and homocysteine in the extracellular fluid in the skin.

Persson, Bertil LU ; Andersson, Anders S LU ; Hultberg, Björn LU and Hansson, Christer LU (2002) In Free Radical Research 36(2). p.151-156
Abstract
Glutathione, the most abundant low-molecular weight thiol in the skin, has been shown to protect the skin from both photobiological and chemical injury. The thiols, glutathione in particular, have also been shown to be crucially involved in defence against contact allergens. Since the levels of extracellular thiol concentrations are important determinants of intracellular thiol status, we have compared the normal concentrations and the redox status of the main low-molecular weight thiol components in the extracellular fluid at the dermo-epidermal junction with the corresponding plasma levels. In their sulfhydryl form, all three thiols, i.e. glutathione, cysteine and homocysteine, were more abundant in experimental skin blister fluid than... (More)
Glutathione, the most abundant low-molecular weight thiol in the skin, has been shown to protect the skin from both photobiological and chemical injury. The thiols, glutathione in particular, have also been shown to be crucially involved in defence against contact allergens. Since the levels of extracellular thiol concentrations are important determinants of intracellular thiol status, we have compared the normal concentrations and the redox status of the main low-molecular weight thiol components in the extracellular fluid at the dermo-epidermal junction with the corresponding plasma levels. In their sulfhydryl form, all three thiols, i.e. glutathione, cysteine and homocysteine, were more abundant in experimental skin blister fluid than in plasma, as were the free disulfides of glutathione and homocysteine, whereas the free disulfides of cysteine were about the same in blister fluid and in plasma. Protein mixed disulfide levels were higher in plasma than in blister fluid. The present results provide information concerning the extracellular defence in the skin. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Free Radical Research
volume
36
issue
2
pages
151 - 156
publisher
Harwood Academic
external identifiers
  • pmid:11999382
  • wos:000174341700004
  • scopus:0036486752
ISSN
1029-2470
DOI
10.1080/10715760290006448
language
English
LU publication?
yes
id
385c645f-6cfa-4d22-89e0-00476eeed80f (old id 108088)
alternative location
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=11999382&dopt=Abstract
date added to LUP
2007-07-03 08:56:05
date last changed
2017-01-01 07:06:19
@article{385c645f-6cfa-4d22-89e0-00476eeed80f,
  abstract     = {Glutathione, the most abundant low-molecular weight thiol in the skin, has been shown to protect the skin from both photobiological and chemical injury. The thiols, glutathione in particular, have also been shown to be crucially involved in defence against contact allergens. Since the levels of extracellular thiol concentrations are important determinants of intracellular thiol status, we have compared the normal concentrations and the redox status of the main low-molecular weight thiol components in the extracellular fluid at the dermo-epidermal junction with the corresponding plasma levels. In their sulfhydryl form, all three thiols, i.e. glutathione, cysteine and homocysteine, were more abundant in experimental skin blister fluid than in plasma, as were the free disulfides of glutathione and homocysteine, whereas the free disulfides of cysteine were about the same in blister fluid and in plasma. Protein mixed disulfide levels were higher in plasma than in blister fluid. The present results provide information concerning the extracellular defence in the skin.},
  author       = {Persson, Bertil and Andersson, Anders S and Hultberg, Björn and Hansson, Christer},
  issn         = {1029-2470},
  language     = {eng},
  number       = {2},
  pages        = {151--156},
  publisher    = {Harwood Academic},
  series       = {Free Radical Research},
  title        = {The redox state of glutathione, cysteine and homocysteine in the extracellular fluid in the skin.},
  url          = {http://dx.doi.org/10.1080/10715760290006448},
  volume       = {36},
  year         = {2002},
}