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Evidence for electrical remodelling of the atrial myocardium in patients with atrial fibrillation. A study using the monophasic action potential recording technique.

Hertervig, Eva LU ; Yuan, Shiwen LU ; Carlson, Jonas LU ; Kongstad-Rasmussen, Ole and Olsson, Bertil LU (2002) In Clinical Physiology and Functional Imaging2002-01-01+01:00 22(1). p.8-12
Abstract
Experimental studies have shown that remodelling of the atrial myocardium is linked to the occurrence and perpetuation of atrial fibrillation (AF). Clinical evidence, however, is insufficient. We recorded monophasic action potentials (MAP) during AF from one to three sites in the right atrium in seven patients with chronic AF (CAF) and in 11 patients with paroxysmal AF (PAF). The fibrillatory (FF) interval between two consecutive upstrokes of the MAP was measured using a computer-assisted manual method. The mean, median, 15th, 10th, 5th percentile and shortest FF intervals were calculated in each patient and used as estimates of the local atrial effective refractory period (AERP) during AF. In three patients burst pacing at 400 and 500... (More)
Experimental studies have shown that remodelling of the atrial myocardium is linked to the occurrence and perpetuation of atrial fibrillation (AF). Clinical evidence, however, is insufficient. We recorded monophasic action potentials (MAP) during AF from one to three sites in the right atrium in seven patients with chronic AF (CAF) and in 11 patients with paroxysmal AF (PAF). The fibrillatory (FF) interval between two consecutive upstrokes of the MAP was measured using a computer-assisted manual method. The mean, median, 15th, 10th, 5th percentile and shortest FF intervals were calculated in each patient and used as estimates of the local atrial effective refractory period (AERP) during AF. In three patients burst pacing at 400 and 500 beats min(-1) was delivered during the MAP recording. In nine patients, the AERP was also tested using the extra stimulus technique during sinus rhythm. RESULTS: Thirty-eight recordings were obtained. The shortest FF interval was significantly shorter in patients with CAF as compared with that in patients with PAF (50+/-13 vs. 72+/-31 ms, P<005). Similar differences were seen in the mean, median, 15th, 10th, and 5th percentile FF interval. The AERP during sinusrhythm was significantly longer than the estimated AERPs (P<0 05 to P<0.01) in the nine patients. There was no significant difference in FF interval before and after the burst pacing in the three patients. CONCLUSION: The AERP was significantly shortened during AF, as compared with that during sinus rhythm, and the AERP shortening was more marked in patients with CAF than in patients with PAF. These clinical findings support the connection between the electrical remodelling and the occurrence and/ or perpetuation of the AF. (Less)
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Contribution to journal
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published
subject
keywords
Comparative Study, Electrocardiography, Neurologic, Refractory Period, Middle Age, Male, Human, Heart Conduction System : physiopathology, Heart : physiopathology, Electrophysiology, Female, Chronic Disease, Atrial Function, Atrial Fibrillation : physiopathology, Action Potentials
in
Clinical Physiology and Functional Imaging2002-01-01+01:00
volume
22
issue
1
pages
8 - 12
publisher
Wiley Online Library
external identifiers
  • pmid:12003106
  • wos:000174885800004
  • scopus:0036256818
ISSN
1475-0961
DOI
10.1046/j.1475-097X.2002.00384.x
language
English
LU publication?
yes
id
9f8d5a7e-38d7-4930-bf5a-a586017a6453 (old id 108110)
alternative location
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12003106&dopt=Abstract
date added to LUP
2007-07-02 10:51:52
date last changed
2017-08-13 03:27:38
@article{9f8d5a7e-38d7-4930-bf5a-a586017a6453,
  abstract     = {Experimental studies have shown that remodelling of the atrial myocardium is linked to the occurrence and perpetuation of atrial fibrillation (AF). Clinical evidence, however, is insufficient. We recorded monophasic action potentials (MAP) during AF from one to three sites in the right atrium in seven patients with chronic AF (CAF) and in 11 patients with paroxysmal AF (PAF). The fibrillatory (FF) interval between two consecutive upstrokes of the MAP was measured using a computer-assisted manual method. The mean, median, 15th, 10th, 5th percentile and shortest FF intervals were calculated in each patient and used as estimates of the local atrial effective refractory period (AERP) during AF. In three patients burst pacing at 400 and 500 beats min(-1) was delivered during the MAP recording. In nine patients, the AERP was also tested using the extra stimulus technique during sinus rhythm. RESULTS: Thirty-eight recordings were obtained. The shortest FF interval was significantly shorter in patients with CAF as compared with that in patients with PAF (50+/-13 vs. 72+/-31 ms, P&lt;005). Similar differences were seen in the mean, median, 15th, 10th, and 5th percentile FF interval. The AERP during sinusrhythm was significantly longer than the estimated AERPs (P&lt;0 05 to P&lt;0.01) in the nine patients. There was no significant difference in FF interval before and after the burst pacing in the three patients. CONCLUSION: The AERP was significantly shortened during AF, as compared with that during sinus rhythm, and the AERP shortening was more marked in patients with CAF than in patients with PAF. These clinical findings support the connection between the electrical remodelling and the occurrence and/ or perpetuation of the AF.},
  author       = {Hertervig, Eva and Yuan, Shiwen and Carlson, Jonas and Kongstad-Rasmussen, Ole and Olsson, Bertil},
  issn         = {1475-0961},
  keyword      = {Comparative Study,Electrocardiography,Neurologic,Refractory Period,Middle Age,Male,Human,Heart Conduction System : physiopathology,Heart : physiopathology,Electrophysiology,Female,Chronic Disease,Atrial Function,Atrial Fibrillation : physiopathology,Action Potentials},
  language     = {eng},
  number       = {1},
  pages        = {8--12},
  publisher    = {Wiley Online Library},
  series       = {Clinical Physiology and Functional Imaging2002-01-01+01:00},
  title        = {Evidence for electrical remodelling of the atrial myocardium in patients with atrial fibrillation. A study using the monophasic action potential recording technique.},
  url          = {http://dx.doi.org/10.1046/j.1475-097X.2002.00384.x},
  volume       = {22},
  year         = {2002},
}