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Treatment of the overactive bladder: possible central nervous system drug targets.

Andersson, Karl-Erik LU (2002) In Urology 59(5 Suppl 1). p.18-24
Abstract
The well-known side effects of antimuscarinic drugs have focused interest on other modalities of treatment of the overactive bladder. To effectively control bladder activity, identification of suitable targets for pharmacologic intervention is necessary. Such targets may be found in the central nervous system (CNS) or peripherally. Several CNS transmitters may modulate voiding, but few drugs with a defined CNS site of action have been developed for treatment of voiding disorders. Drugs affecting gamma-aminobutyric acid, opioid, serotonin, noradrenaline, dopamine, or glutamatergic receptors and mechanisms are known to influence micturition, and potentially such drugs could be developed for clinical use. However, a selective action on the... (More)
The well-known side effects of antimuscarinic drugs have focused interest on other modalities of treatment of the overactive bladder. To effectively control bladder activity, identification of suitable targets for pharmacologic intervention is necessary. Such targets may be found in the central nervous system (CNS) or peripherally. Several CNS transmitters may modulate voiding, but few drugs with a defined CNS site of action have been developed for treatment of voiding disorders. Drugs affecting gamma-aminobutyric acid, opioid, serotonin, noradrenaline, dopamine, or glutamatergic receptors and mechanisms are known to influence micturition, and potentially such drugs could be developed for clinical use. However, a selective action on the lower urinary tract may be difficult to obtain. (Less)
Please use this url to cite or link to this publication:
author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Bladder Diseases : physiopathology, Bladder Diseases : drug therapy, Dopamine : physiology, Human, Muscarinic Antagonists : therapeutic use, Norepinephrine : physiology, Support, Serotonin : physiology, Non-U.S. Gov't, gamma-Aminobutyric Acid : physiology
in
Urology
volume
59
issue
5 Suppl 1
pages
18 - 24
publisher
Elsevier
external identifiers
  • wos:000175489900004
  • pmid:12007518
  • scopus:0036234254
ISSN
1527-9995
DOI
10.1016/S0090-4295(01)01634-X
language
English
LU publication?
yes
id
9287ff12-51a2-4e7a-af6f-fd3ec59df315 (old id 108195)
alternative location
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12007518&dopt=Abstract
date added to LUP
2007-07-04 15:00:13
date last changed
2017-04-09 03:31:09
@article{9287ff12-51a2-4e7a-af6f-fd3ec59df315,
  abstract     = {The well-known side effects of antimuscarinic drugs have focused interest on other modalities of treatment of the overactive bladder. To effectively control bladder activity, identification of suitable targets for pharmacologic intervention is necessary. Such targets may be found in the central nervous system (CNS) or peripherally. Several CNS transmitters may modulate voiding, but few drugs with a defined CNS site of action have been developed for treatment of voiding disorders. Drugs affecting gamma-aminobutyric acid, opioid, serotonin, noradrenaline, dopamine, or glutamatergic receptors and mechanisms are known to influence micturition, and potentially such drugs could be developed for clinical use. However, a selective action on the lower urinary tract may be difficult to obtain.},
  author       = {Andersson, Karl-Erik},
  issn         = {1527-9995},
  keyword      = {Bladder Diseases : physiopathology,Bladder Diseases : drug therapy,Dopamine : physiology,Human,Muscarinic Antagonists : therapeutic use,Norepinephrine : physiology,Support,Serotonin : physiology,Non-U.S. Gov't,gamma-Aminobutyric Acid : physiology},
  language     = {eng},
  number       = {5 Suppl 1},
  pages        = {18--24},
  publisher    = {Elsevier},
  series       = {Urology},
  title        = {Treatment of the overactive bladder: possible central nervous system drug targets.},
  url          = {http://dx.doi.org/10.1016/S0090-4295(01)01634-X},
  volume       = {59},
  year         = {2002},
}