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Latent autoimmune diabetes in adults.

Landin-Olsson, Mona LU (2002) In Annals of the New York Academy of Sciences 958. p.112-116
Abstract
Latent autoimmune diabetes in adults (LADA) is a special form of diabetes that is clinically similar to type 2 diabetes but with positivity for pancreatic autoantibodies. The frequency of LADA patients among all patients diagnosed as type 2 varies between 6-50% in various populations. The frequency is higher in younger age groups. It is clear, however, that the frequency of autoimmune diabetes among adults is underestimated. Clinical features such as age and severity of symptoms are of no help in identifying these patients. Body mass index and C peptide levels in the general population increase with age, and these parameters are of limited use in identifying LADA patients. Determination of autoantibodies is necessary in order to correctly... (More)
Latent autoimmune diabetes in adults (LADA) is a special form of diabetes that is clinically similar to type 2 diabetes but with positivity for pancreatic autoantibodies. The frequency of LADA patients among all patients diagnosed as type 2 varies between 6-50% in various populations. The frequency is higher in younger age groups. It is clear, however, that the frequency of autoimmune diabetes among adults is underestimated. Clinical features such as age and severity of symptoms are of no help in identifying these patients. Body mass index and C peptide levels in the general population increase with age, and these parameters are of limited use in identifying LADA patients. Determination of autoantibodies is necessary in order to correctly classify the type of diabetes. Among antibodies, GADA is the most frequently occurring autoantibody, followed by ICA. The natural course of these patients shows that C peptide will decrease with time in parallel with the curve for C peptide in classical type 1 diabetic patients. Most of the LADA patients will require insulin within three years. Our recommendation is that all patients be tested for pancreatic islet autoantibodies at diagnosis of diabetes to enable correct diagnosis and to avoid future failure of hypoglycemic agents and risk of complications due to hyperglycemia. It is still unclear whether early treatment with insulin is beneficial for the remaining beta cells. (Less)
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published
subject
keywords
Diabetes Mellitus, Insulin-Dependent : classification, C-Peptide : metabolism, Autoantibodies : immunology, Age of Onset, Adult, Non-Insulin-Dependent : classification, Non-Insulin-Dependent : diagnosis, Non-Insulin-Dependent : immunology, Non-Insulin-Dependent : physiopathology, Diagnosis, Differential, Follow-Up Studies, Glutamate Decarboxylase : immunology, Human, Insulin-Dependent : diagnosis, Insulin-Dependent : immunology, Insulin-Dependent : physiopathology, Adolescence
in
Annals of the New York Academy of Sciences
volume
958
pages
112 - 116
publisher
New York Academy of Sciences
external identifiers
  • pmid:12021090
  • wos:000176952100014
ISSN
0077-8923
DOI
10.1111/j.1749-6632.2002.tb02953.x
language
English
LU publication?
yes
id
98550bb3-28fa-42de-97fa-3afb2ce3f11b (old id 108340)
alternative location
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12021090&dopt=Abstract
date added to LUP
2007-06-29 11:57:27
date last changed
2016-04-16 05:06:35
@article{98550bb3-28fa-42de-97fa-3afb2ce3f11b,
  abstract     = {Latent autoimmune diabetes in adults (LADA) is a special form of diabetes that is clinically similar to type 2 diabetes but with positivity for pancreatic autoantibodies. The frequency of LADA patients among all patients diagnosed as type 2 varies between 6-50% in various populations. The frequency is higher in younger age groups. It is clear, however, that the frequency of autoimmune diabetes among adults is underestimated. Clinical features such as age and severity of symptoms are of no help in identifying these patients. Body mass index and C peptide levels in the general population increase with age, and these parameters are of limited use in identifying LADA patients. Determination of autoantibodies is necessary in order to correctly classify the type of diabetes. Among antibodies, GADA is the most frequently occurring autoantibody, followed by ICA. The natural course of these patients shows that C peptide will decrease with time in parallel with the curve for C peptide in classical type 1 diabetic patients. Most of the LADA patients will require insulin within three years. Our recommendation is that all patients be tested for pancreatic islet autoantibodies at diagnosis of diabetes to enable correct diagnosis and to avoid future failure of hypoglycemic agents and risk of complications due to hyperglycemia. It is still unclear whether early treatment with insulin is beneficial for the remaining beta cells.},
  author       = {Landin-Olsson, Mona},
  issn         = {0077-8923},
  keyword      = {Diabetes Mellitus,Insulin-Dependent : classification,C-Peptide : metabolism,Autoantibodies : immunology,Age of Onset,Adult,Non-Insulin-Dependent : classification,Non-Insulin-Dependent : diagnosis,Non-Insulin-Dependent : immunology,Non-Insulin-Dependent : physiopathology,Diagnosis,Differential,Follow-Up Studies,Glutamate Decarboxylase : immunology,Human,Insulin-Dependent : diagnosis,Insulin-Dependent : immunology,Insulin-Dependent : physiopathology,Adolescence},
  language     = {eng},
  pages        = {112--116},
  publisher    = {New York Academy of Sciences},
  series       = {Annals of the New York Academy of Sciences},
  title        = {Latent autoimmune diabetes in adults.},
  url          = {http://dx.doi.org/10.1111/j.1749-6632.2002.tb02953.x},
  volume       = {958},
  year         = {2002},
}