Advanced

Genetic variability in hepatitis B viruses.

Kidd-Ljunggren, Karin LU ; Miyakawa, Yuzo and Kidd, Alistair H (2002) In Journal of General Virology 83(Pt 6). p.1267-1280
Abstract
In 1988, it was reported that the full nucleotide sequences of 18 hepatitis B virus (HBV) strains clustered into four genetic groups (A to D) with more than 8% divergence between the groups. This classification of strains in terms of genome sequence has since proven to be an important tool in the understanding of HBV epidemiology and evolution and has been expanded to include three more genotypes. In parallel with the HBV genotypes described in humans, HBV strains isolated from different primates and hepadnaviruses found in woodchucks, ground squirrels, ducks and herons have been studied. Sequence differences between HBV genotypes can lead to structural differences at the level of the pregenome and can also lead to dramatic differences at... (More)
In 1988, it was reported that the full nucleotide sequences of 18 hepatitis B virus (HBV) strains clustered into four genetic groups (A to D) with more than 8% divergence between the groups. This classification of strains in terms of genome sequence has since proven to be an important tool in the understanding of HBV epidemiology and evolution and has been expanded to include three more genotypes. In parallel with the HBV genotypes described in humans, HBV strains isolated from different primates and hepadnaviruses found in woodchucks, ground squirrels, ducks and herons have been studied. Sequence differences between HBV genotypes can lead to structural differences at the level of the pregenome and can also lead to dramatic differences at the translational level when specific and commonly occurring mutations occur. There is increasing evidence that the clinical picture, the response to treatment and the long-term prognosis may differ depending on which genotype has infected the patient. The consideration of traditional serological patterns in a patient must therefore take the genotype of the infecting strain into account. Nucleotide variability between HBV strains has been used in several studies to trace routes of transmission and, since it is becoming increasingly clear that the differences between HBV genotypes are important, the need for reliable and easy methods of differentiating HBV genotypes has arisen. This review summarizes the knowledge of HBV genotypes with regard to their genetic, structural and clinically significant differences and their origin and evolution in the context of the hepadnaviruses in general. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Animal, Evolution, Genotype, Hepadnaviridae : genetics, Hepatitis B : physiopathology, Hepatitis B : virology, Hepatitis B Virus : classification, Hepatitis B Virus : genetics, Human, Molecular Sequence Data, Mutation, Base Sequence
in
Journal of General Virology
volume
83
issue
Pt 6
pages
1267 - 1280
publisher
Society for General Microbiology
external identifiers
  • pmid:12029141
  • wos:000175768200002
  • scopus:0036274616
ISSN
1465-2099
DOI
10.1099/vir.O.18197-O
language
English
LU publication?
yes
id
e2f3bd5d-901d-42c2-b46c-f92bb1c0422a (old id 108485)
alternative location
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12029141&dopt=Abstract
date added to LUP
2007-07-04 16:39:32
date last changed
2017-11-26 03:40:46
@article{e2f3bd5d-901d-42c2-b46c-f92bb1c0422a,
  abstract     = {In 1988, it was reported that the full nucleotide sequences of 18 hepatitis B virus (HBV) strains clustered into four genetic groups (A to D) with more than 8% divergence between the groups. This classification of strains in terms of genome sequence has since proven to be an important tool in the understanding of HBV epidemiology and evolution and has been expanded to include three more genotypes. In parallel with the HBV genotypes described in humans, HBV strains isolated from different primates and hepadnaviruses found in woodchucks, ground squirrels, ducks and herons have been studied. Sequence differences between HBV genotypes can lead to structural differences at the level of the pregenome and can also lead to dramatic differences at the translational level when specific and commonly occurring mutations occur. There is increasing evidence that the clinical picture, the response to treatment and the long-term prognosis may differ depending on which genotype has infected the patient. The consideration of traditional serological patterns in a patient must therefore take the genotype of the infecting strain into account. Nucleotide variability between HBV strains has been used in several studies to trace routes of transmission and, since it is becoming increasingly clear that the differences between HBV genotypes are important, the need for reliable and easy methods of differentiating HBV genotypes has arisen. This review summarizes the knowledge of HBV genotypes with regard to their genetic, structural and clinically significant differences and their origin and evolution in the context of the hepadnaviruses in general.},
  author       = {Kidd-Ljunggren, Karin and Miyakawa, Yuzo and Kidd, Alistair H},
  issn         = {1465-2099},
  keyword      = {Animal,Evolution,Genotype,Hepadnaviridae : genetics,Hepatitis B : physiopathology,Hepatitis B : virology,Hepatitis B Virus : classification,Hepatitis B Virus : genetics,Human,Molecular Sequence Data,Mutation,Base Sequence},
  language     = {eng},
  number       = {Pt 6},
  pages        = {1267--1280},
  publisher    = {Society for General Microbiology},
  series       = {Journal of General Virology},
  title        = {Genetic variability in hepatitis B viruses.},
  url          = {http://dx.doi.org/10.1099/vir.O.18197-O},
  volume       = {83},
  year         = {2002},
}