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Individual risk assessment of thrombosis in pregnancy.

Lindqvist, Pelle LU ; Kublikas, Marius and Dahlbäck, Björn LU (2002) In Acta Obstetricia et Gynecologica Scandinavica 81(5). p.412-416
Abstract
Thromboembolic complications during pregnancy are major contributors to maternal death, but there is no reliable way to estimate the absolute risk of thrombosis before the occurrence of a thromboembolic complication. OBJECTIVE: To create a model for individual estimation of thrombosis risk during pregnancy and to determine the distribution of risk estimates in a series of gravidae. METHOD AND PATIENTS: Estimates of absolute risk of pregnancy-related thromboembolism were calculated by multiplying reported figures of thrombosis incidence by prevalence-adjusted odds ratios of the following variables: smoking, parity, preeclampsia, mode of delivery, age, overweight, activated protein C resistance (FV Leiden or FV:Q506), thrombosis heredity,... (More)
Thromboembolic complications during pregnancy are major contributors to maternal death, but there is no reliable way to estimate the absolute risk of thrombosis before the occurrence of a thromboembolic complication. OBJECTIVE: To create a model for individual estimation of thrombosis risk during pregnancy and to determine the distribution of risk estimates in a series of gravidae. METHOD AND PATIENTS: Estimates of absolute risk of pregnancy-related thromboembolism were calculated by multiplying reported figures of thrombosis incidence by prevalence-adjusted odds ratios of the following variables: smoking, parity, preeclampsia, mode of delivery, age, overweight, activated protein C resistance (FV Leiden or FV:Q506), thrombosis heredity, and previous thrombosis. We present the risk distribution among a unselected prospectively gathered cohort of 2384 unselected gravidae who were interviewed and tested for activated protein C resistance in early pregnancy. RESULTS AND CONCLUSIONS: A model for individual estimation of the absolute risk of thrombosis is presented, which is provided to the readers as a free automatic Internet-based service (http://www.riskpreg.com). As compared with antepartum, more women at high risk can be identified in the postpartum period and we suggest that this might be of use in planning the prevention of thrombosis. (Less)
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organization
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Contribution to journal
publication status
published
subject
keywords
Pregnancy Complications, Cardiovascular : epidemiology, Cardiovascular : etiology, Cardiovascular : prevention & control, Prevalence, Prospective Studies, Risk Assessment, Risk Factors, Support, Non-U.S. Gov't, Thromboembolism : prevention & control, Thromboembolism : etiology, Sweden : epidemiology, Thromboembolism : epidemiology, Odds Ratio, Pregnancy, Obesity, Human, Female, Adult, Cohort Studies
in
Acta Obstetricia et Gynecologica Scandinavica
volume
81
issue
5
pages
412 - 416
publisher
Wiley-Blackwell
external identifiers
  • wos:000175698400007
  • pmid:12027814
  • scopus:0036093454
ISSN
1600-0412
DOI
10.1034/j.1600-0412.2002.810507.x
language
English
LU publication?
yes
id
79eff8c4-b5b3-49a9-aa58-b9405b0d663a (old id 108490)
date added to LUP
2007-07-26 08:36:15
date last changed
2017-10-29 04:12:07
@article{79eff8c4-b5b3-49a9-aa58-b9405b0d663a,
  abstract     = {Thromboembolic complications during pregnancy are major contributors to maternal death, but there is no reliable way to estimate the absolute risk of thrombosis before the occurrence of a thromboembolic complication. OBJECTIVE: To create a model for individual estimation of thrombosis risk during pregnancy and to determine the distribution of risk estimates in a series of gravidae. METHOD AND PATIENTS: Estimates of absolute risk of pregnancy-related thromboembolism were calculated by multiplying reported figures of thrombosis incidence by prevalence-adjusted odds ratios of the following variables: smoking, parity, preeclampsia, mode of delivery, age, overweight, activated protein C resistance (FV Leiden or FV:Q506), thrombosis heredity, and previous thrombosis. We present the risk distribution among a unselected prospectively gathered cohort of 2384 unselected gravidae who were interviewed and tested for activated protein C resistance in early pregnancy. RESULTS AND CONCLUSIONS: A model for individual estimation of the absolute risk of thrombosis is presented, which is provided to the readers as a free automatic Internet-based service (http://www.riskpreg.com). As compared with antepartum, more women at high risk can be identified in the postpartum period and we suggest that this might be of use in planning the prevention of thrombosis.},
  author       = {Lindqvist, Pelle and Kublikas, Marius and Dahlbäck, Björn},
  issn         = {1600-0412},
  keyword      = {Pregnancy Complications,Cardiovascular : epidemiology,Cardiovascular : etiology,Cardiovascular : prevention & control,Prevalence,Prospective Studies,Risk Assessment,Risk Factors,Support,Non-U.S. Gov't,Thromboembolism : prevention & control,Thromboembolism : etiology,Sweden : epidemiology,Thromboembolism : epidemiology,Odds Ratio,Pregnancy,Obesity,Human,Female,Adult,Cohort Studies},
  language     = {eng},
  number       = {5},
  pages        = {412--416},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Obstetricia et Gynecologica Scandinavica},
  title        = {Individual risk assessment of thrombosis in pregnancy.},
  url          = {http://dx.doi.org/10.1034/j.1600-0412.2002.810507.x},
  volume       = {81},
  year         = {2002},
}