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Hypersensitivity to noradrenaline in human omental vein but not artery isolated from a patient with idiopathic orthostatic hypotension.

Hidestål, Joakim; Fredriksen, Sven; Hallén, Magnus LU ; Westerdahl, Johan LU ; Thysell, Hans LU and Bodelsson, Mikael LU (2002) In Autonomic Neuroscience: Basic & Clinical2000-01-01+01:00 97(1). p.55-58
Abstract
We investigated the smooth muscle contraction in response to noradrenaline (NA), endothelin-1 (ET) and 5-hydroxytryptamine (5-HT) in the omental artery and vein segments from a 67-year-old woman with idiopathic orthostatic hypotension. The blood vessels were obtained during the abdominal surgery and investigated in vitro. Noradrenaline, endothelin-1 and 5-hydroxytryptamine all induced a contraction in the artery and vein segments. Compared to the literature, the sensitivity to noradrenaline was 10 times higher than expected in the vein. In the artery, the sensitivity to noradrenaline and in both the artery and vein, the sensitivity to endothelin-1 and 5-hydroxytryptamine was similar to that reported in the literature. These results suggest... (More)
We investigated the smooth muscle contraction in response to noradrenaline (NA), endothelin-1 (ET) and 5-hydroxytryptamine (5-HT) in the omental artery and vein segments from a 67-year-old woman with idiopathic orthostatic hypotension. The blood vessels were obtained during the abdominal surgery and investigated in vitro. Noradrenaline, endothelin-1 and 5-hydroxytryptamine all induced a contraction in the artery and vein segments. Compared to the literature, the sensitivity to noradrenaline was 10 times higher than expected in the vein. In the artery, the sensitivity to noradrenaline and in both the artery and vein, the sensitivity to endothelin-1 and 5-hydroxytryptamine was similar to that reported in the literature. These results suggest that the patient had developed an isolated hypersensitivity to noradrenaline in the veins, probably due to an impairment of the sympathetic activity. (Less)
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organization
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Contribution to journal
publication status
published
subject
in
Autonomic Neuroscience: Basic & Clinical2000-01-01+01:00
volume
97
issue
1
pages
55 - 58
publisher
Elsevier
external identifiers
  • pmid:12036187
  • wos:000175594500008
  • scopus:0037129141
ISSN
1872-7484
DOI
10.1016/S1566-0702(02)00015-2
language
English
LU publication?
yes
id
bc4da676-d36a-4742-9cc3-5eaa3eeb0a88 (old id 108585)
alternative location
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=12036187&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
date added to LUP
2007-06-28 09:28:01
date last changed
2017-01-01 05:19:14
@article{bc4da676-d36a-4742-9cc3-5eaa3eeb0a88,
  abstract     = {We investigated the smooth muscle contraction in response to noradrenaline (NA), endothelin-1 (ET) and 5-hydroxytryptamine (5-HT) in the omental artery and vein segments from a 67-year-old woman with idiopathic orthostatic hypotension. The blood vessels were obtained during the abdominal surgery and investigated in vitro. Noradrenaline, endothelin-1 and 5-hydroxytryptamine all induced a contraction in the artery and vein segments. Compared to the literature, the sensitivity to noradrenaline was 10 times higher than expected in the vein. In the artery, the sensitivity to noradrenaline and in both the artery and vein, the sensitivity to endothelin-1 and 5-hydroxytryptamine was similar to that reported in the literature. These results suggest that the patient had developed an isolated hypersensitivity to noradrenaline in the veins, probably due to an impairment of the sympathetic activity.},
  author       = {Hidestål, Joakim and Fredriksen, Sven and Hallén, Magnus and Westerdahl, Johan and Thysell, Hans and Bodelsson, Mikael},
  issn         = {1872-7484},
  language     = {eng},
  number       = {1},
  pages        = {55--58},
  publisher    = {Elsevier},
  series       = {Autonomic Neuroscience: Basic & Clinical2000-01-01+01:00},
  title        = {Hypersensitivity to noradrenaline in human omental vein but not artery isolated from a patient with idiopathic orthostatic hypotension.},
  url          = {http://dx.doi.org/10.1016/S1566-0702(02)00015-2},
  volume       = {97},
  year         = {2002},
}