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Cardiovascular pharmacology of anandamide.

Högestätt, Edward LU and Zygmunt, Peter LU (2002) In Prostaglandins, Leukotrienes and Essential Fatty Acids 66(2-3). p.343-351
Abstract
The fatty acid amide anandamide produces hypotension and a decrease in systemic vascular resistance in vivo. A drop in blood pressure is also seen with synthetic cannabinoid (CB) receptor agonists. The hypotensive responses to anandamide and synthetic cannabinoids are absent in CB1 receptor gene knockout mice. In isolated arteries and perfused vascular beds, anandamide induces vasodilator responses, which cannot be mimicked by synthetic cannabinoids. Instead, vanilloid receptors on perivascular sensory nerves play a key role in these effects of anandamide. Activation of vanilloid receptors by anandamide triggers the release of sensory neuropeptides such as the vasodilator calcitonin gene-related peptide (CGRP). Anandamide is detected in... (More)
The fatty acid amide anandamide produces hypotension and a decrease in systemic vascular resistance in vivo. A drop in blood pressure is also seen with synthetic cannabinoid (CB) receptor agonists. The hypotensive responses to anandamide and synthetic cannabinoids are absent in CB1 receptor gene knockout mice. In isolated arteries and perfused vascular beds, anandamide induces vasodilator responses, which cannot be mimicked by synthetic cannabinoids. Instead, vanilloid receptors on perivascular sensory nerves play a key role in these effects of anandamide. Activation of vanilloid receptors by anandamide triggers the release of sensory neuropeptides such as the vasodilator calcitonin gene-related peptide (CGRP). Anandamide is detected in blood and in many cells of the cardiovascular system, and macrophage-derived anandamide may be involved in several hypotensive clinical conditions. Interestingly, cannabinoid and vanilloid receptors display an overlap in ligand recognition properties, and the frequently used CB1 receptor antagonist SR141716A also inhibits vanilloid receptor-mediated responses. The presence of anandamide in endothelial cells, neurones and activated macrophages (monocytes), and its ability to activate CB and vanilloid receptors make this lipid a potential bioregulator in the cardiovascular system. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Prostaglandins, Leukotrienes and Essential Fatty Acids
volume
66
issue
2-3
pages
343 - 351
publisher
Elsevier
external identifiers
  • wos:000176717100021
  • scopus:0036019419
ISSN
0952-3278
DOI
10.1054/plef.2001.0346
language
English
LU publication?
yes
id
79d3c873-8076-441d-876a-70e15537ce2c (old id 108695)
alternative location
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12052048&dopt=Abstract
date added to LUP
2007-07-05 10:47:23
date last changed
2017-08-13 03:37:49
@article{79d3c873-8076-441d-876a-70e15537ce2c,
  abstract     = {The fatty acid amide anandamide produces hypotension and a decrease in systemic vascular resistance in vivo. A drop in blood pressure is also seen with synthetic cannabinoid (CB) receptor agonists. The hypotensive responses to anandamide and synthetic cannabinoids are absent in CB1 receptor gene knockout mice. In isolated arteries and perfused vascular beds, anandamide induces vasodilator responses, which cannot be mimicked by synthetic cannabinoids. Instead, vanilloid receptors on perivascular sensory nerves play a key role in these effects of anandamide. Activation of vanilloid receptors by anandamide triggers the release of sensory neuropeptides such as the vasodilator calcitonin gene-related peptide (CGRP). Anandamide is detected in blood and in many cells of the cardiovascular system, and macrophage-derived anandamide may be involved in several hypotensive clinical conditions. Interestingly, cannabinoid and vanilloid receptors display an overlap in ligand recognition properties, and the frequently used CB1 receptor antagonist SR141716A also inhibits vanilloid receptor-mediated responses. The presence of anandamide in endothelial cells, neurones and activated macrophages (monocytes), and its ability to activate CB and vanilloid receptors make this lipid a potential bioregulator in the cardiovascular system.},
  author       = {Högestätt, Edward and Zygmunt, Peter},
  issn         = {0952-3278},
  language     = {eng},
  number       = {2-3},
  pages        = {343--351},
  publisher    = {Elsevier},
  series       = {Prostaglandins, Leukotrienes and Essential Fatty Acids},
  title        = {Cardiovascular pharmacology of anandamide.},
  url          = {http://dx.doi.org/10.1054/plef.2001.0346},
  volume       = {66},
  year         = {2002},
}