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Optic nerve hypoplasia: Risk factors and epidemiology.

Tornqvist, Kristina LU ; Ericsson, Anders and Källén, Bengt LU (2002) In Acta Ophthalmologica Scandinavica1998-01-01+01:002008-01-01+01:00 80(3). p.300-304
Abstract
OBJECTIVES: To study the epidemiology of optic nerve hypoplasia. DESIGN AND METHODS: Children with optic nerve hypoplasia and visual impairment were identified through the Swedish Register of Visually Impaired Children. Pre- and perinatal characteristics were obtained from the Medical Birth Registry and by scrutinizing pregnancy and delivery records. Clinical characteristics of children with optic nerve hypoplasia are described. The following risk factors were studied: maternal age, parity, maternal smoking, gestational duration, birth weight, delivery method, Apgar score, maternal disease during pregnancy, drugs used in early pregnancy. RESULTS: Young maternal age, first parity, maternal smoking, preterm birth and factors associated with... (More)
OBJECTIVES: To study the epidemiology of optic nerve hypoplasia. DESIGN AND METHODS: Children with optic nerve hypoplasia and visual impairment were identified through the Swedish Register of Visually Impaired Children. Pre- and perinatal characteristics were obtained from the Medical Birth Registry and by scrutinizing pregnancy and delivery records. Clinical characteristics of children with optic nerve hypoplasia are described. The following risk factors were studied: maternal age, parity, maternal smoking, gestational duration, birth weight, delivery method, Apgar score, maternal disease during pregnancy, drugs used in early pregnancy. RESULTS: Young maternal age, first parity, maternal smoking, preterm birth and factors associated with preterm birth were risk factors for optic nerve hypoplasia. There was an indicated association with the use of fertility drugs and antidepressant drugs. CONCLUSIONS: Optic nerve hypoplasia is apparently associated not only with other anomolies, notably of the central nervous system, but also with signs of general disturbance in fetal development. (Less)
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published
subject
keywords
Infant, Human, Female, Eye Abnormalities : epidemiology, Preschool, Child, Adolescence, Adult, Premature, Maternal Age, Male, Optic Nerve : abnormalities, Registries : statistics & numerical data, Risk Factors, Smoking : epidemiology, Non-U.S. Gov't, Support, Sweden : epidemiology, Vision Disorders : epidemiology, Visually Impaired Persons : statistics & numerical data, Newborn
in
Acta Ophthalmologica Scandinavica1998-01-01+01:002008-01-01+01:00
volume
80
issue
3
pages
300 - 304
publisher
Wiley-Blackwell
external identifiers
  • wos:000176204600013
  • pmid:12059870
  • scopus:0036089137
ISSN
1395-3907
DOI
10.1034/j.1600-0420.2002.800313.x
language
English
LU publication?
yes
id
0c17c34b-9755-4db6-b152-8678f6443a80 (old id 108737)
date added to LUP
2007-07-09 10:27:34
date last changed
2017-12-03 03:36:57
@article{0c17c34b-9755-4db6-b152-8678f6443a80,
  abstract     = {OBJECTIVES: To study the epidemiology of optic nerve hypoplasia. DESIGN AND METHODS: Children with optic nerve hypoplasia and visual impairment were identified through the Swedish Register of Visually Impaired Children. Pre- and perinatal characteristics were obtained from the Medical Birth Registry and by scrutinizing pregnancy and delivery records. Clinical characteristics of children with optic nerve hypoplasia are described. The following risk factors were studied: maternal age, parity, maternal smoking, gestational duration, birth weight, delivery method, Apgar score, maternal disease during pregnancy, drugs used in early pregnancy. RESULTS: Young maternal age, first parity, maternal smoking, preterm birth and factors associated with preterm birth were risk factors for optic nerve hypoplasia. There was an indicated association with the use of fertility drugs and antidepressant drugs. CONCLUSIONS: Optic nerve hypoplasia is apparently associated not only with other anomolies, notably of the central nervous system, but also with signs of general disturbance in fetal development.},
  author       = {Tornqvist, Kristina and Ericsson, Anders and Källén, Bengt},
  issn         = {1395-3907},
  keyword      = {Infant,Human,Female,Eye Abnormalities : epidemiology,Preschool,Child,Adolescence,Adult,Premature,Maternal Age,Male,Optic Nerve : abnormalities,Registries : statistics & numerical data,Risk Factors,Smoking : epidemiology,Non-U.S. Gov't,Support,Sweden : epidemiology,Vision Disorders : epidemiology,Visually Impaired Persons : statistics & numerical data,Newborn},
  language     = {eng},
  number       = {3},
  pages        = {300--304},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Ophthalmologica Scandinavica1998-01-01+01:002008-01-01+01:00},
  title        = {Optic nerve hypoplasia: Risk factors and epidemiology.},
  url          = {http://dx.doi.org/10.1034/j.1600-0420.2002.800313.x},
  volume       = {80},
  year         = {2002},
}