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Reciprocal bidirectional plasticity of parallel fiber receptive fields in cerebellar Purkinje cells and their afferent interneurons.

Jörntell, Henrik LU and Ekerot, Carl-Fredrik LU (2002) In Neuron 34(5). p.797-806
Abstract
The highly specific relationships between parallel fiber (PF) and climbing fiber (CF) receptive fields in Purkinje cells and interneurons suggest that normal PF receptive fields are established by CF-specific plasticity. To test this idea, we used PF stimulation that was either paired or unpaired with CF activity. Conspicuously, unpaired PF stimulation that induced long-lasting, very large increases in the receptive field sizes of Purkinje cells induced long-lasting decreases in receptive field sizes of their afferent interneurons. In contrast, PF stimulation paired with CF activity that induced long-lasting decreases in the receptive fields of Purkinje cells induced long-lasting, large increases in the receptive fields of interneurons.... (More)
The highly specific relationships between parallel fiber (PF) and climbing fiber (CF) receptive fields in Purkinje cells and interneurons suggest that normal PF receptive fields are established by CF-specific plasticity. To test this idea, we used PF stimulation that was either paired or unpaired with CF activity. Conspicuously, unpaired PF stimulation that induced long-lasting, very large increases in the receptive field sizes of Purkinje cells induced long-lasting decreases in receptive field sizes of their afferent interneurons. In contrast, PF stimulation paired with CF activity that induced long-lasting decreases in the receptive fields of Purkinje cells induced long-lasting, large increases in the receptive fields of interneurons. These properties, and the fact the mossy fiber receptive fields were unchanged, suggest that the receptive field changes were due to bidirectional PF synaptic plasticity in Purkinje cells and interneurons. (Less)
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keywords
Action Potentials : physiology, Axons : ultrastructure, Cats, Dendrites : physiology, Dendrites : ultrastructure, Electric Stimulation, Excitatory Postsynaptic Potentials : physiology, Interneurons : physiology, Interneurons : cytology, Nerve Net : physiology, Mechanoreceptors : physiology, Neural Inhibition : physiology, Neuronal Plasticity : physiology, Olivary Nucleus : cytology, Synaptic Transmission : physiology, Synapses : ultrastructure, Synapses : physiology, Non-U.S. Gov't, Support, Skin : innervation, Reaction Time : physiology, Purkinje Cells : physiology, Olivary Nucleus : physiology, Purkinje Cells : cytology, Afferent Pathways : cytology, Afferent Pathways : physiology, Animal, Axons : physiology
in
Neuron
volume
34
issue
5
pages
797 - 806
publisher
Cell Press
external identifiers
  • pmid:12062025
  • wos:000175951800013
  • scopus:0037198723
ISSN
0896-6273
DOI
10.1016/S0896-6273(02)00713-4
language
English
LU publication?
yes
id
507f4896-80ad-4318-ace7-744a00bf1856 (old id 108832)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12062025&dopt=Abstract
date added to LUP
2016-04-01 12:02:10
date last changed
2022-04-28 23:34:12
@article{507f4896-80ad-4318-ace7-744a00bf1856,
  abstract     = {{The highly specific relationships between parallel fiber (PF) and climbing fiber (CF) receptive fields in Purkinje cells and interneurons suggest that normal PF receptive fields are established by CF-specific plasticity. To test this idea, we used PF stimulation that was either paired or unpaired with CF activity. Conspicuously, unpaired PF stimulation that induced long-lasting, very large increases in the receptive field sizes of Purkinje cells induced long-lasting decreases in receptive field sizes of their afferent interneurons. In contrast, PF stimulation paired with CF activity that induced long-lasting decreases in the receptive fields of Purkinje cells induced long-lasting, large increases in the receptive fields of interneurons. These properties, and the fact the mossy fiber receptive fields were unchanged, suggest that the receptive field changes were due to bidirectional PF synaptic plasticity in Purkinje cells and interneurons.}},
  author       = {{Jörntell, Henrik and Ekerot, Carl-Fredrik}},
  issn         = {{0896-6273}},
  keywords     = {{Action Potentials : physiology; Axons : ultrastructure; Cats; Dendrites : physiology; Dendrites : ultrastructure; Electric Stimulation; Excitatory Postsynaptic Potentials : physiology; Interneurons : physiology; Interneurons : cytology; Nerve Net : physiology; Mechanoreceptors : physiology; Neural Inhibition : physiology; Neuronal Plasticity : physiology; Olivary Nucleus : cytology; Synaptic Transmission : physiology; Synapses : ultrastructure; Synapses : physiology; Non-U.S. Gov't; Support; Skin : innervation; Reaction Time : physiology; Purkinje Cells : physiology; Olivary Nucleus : physiology; Purkinje Cells : cytology; Afferent Pathways : cytology; Afferent Pathways : physiology; Animal; Axons : physiology}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{797--806}},
  publisher    = {{Cell Press}},
  series       = {{Neuron}},
  title        = {{Reciprocal bidirectional plasticity of parallel fiber receptive fields in cerebellar Purkinje cells and their afferent interneurons.}},
  url          = {{http://dx.doi.org/10.1016/S0896-6273(02)00713-4}},
  doi          = {{10.1016/S0896-6273(02)00713-4}},
  volume       = {{34}},
  year         = {{2002}},
}