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The quotient end-tidal/inspired concentration of sevoflurane in a low-flow system.

Johansson, Anders LU ; Lundberg, Dag LU and Luttropp, Hans-Henrik LU (2002) In Journal of Clinical Anesthesia 14(4). p.267-270
Abstract
STUDY OBJECTIVE: To investigate the effect of two different fresh gas flows on inspired and end-tidal sevoflurane concentration for a given vaporizer setting in a low-flow anesthesia system.DESIGN: Prospective clinical study.SETTING: Department of Anesthesiology of a university teaching hospital.PATIENTS: 56 ASA physical status I and II patients without systemic diseases, having elective surgery with an expected anesthesia time of at least 120 minutes.INTERVENTIONS: Patients were randomly assigned to receive either 1.0 or 2.0 L/min fresh gas flow with the vaporizer setting fixed at 2% sevoflurane. The inspired (In), end-tidal (Et), and Et/In ratio sevoflurane concentrations were estimated.MEASUREMENTS AND MAIN RESULTS: After 120 minutes of... (More)
STUDY OBJECTIVE: To investigate the effect of two different fresh gas flows on inspired and end-tidal sevoflurane concentration for a given vaporizer setting in a low-flow anesthesia system.DESIGN: Prospective clinical study.SETTING: Department of Anesthesiology of a university teaching hospital.PATIENTS: 56 ASA physical status I and II patients without systemic diseases, having elective surgery with an expected anesthesia time of at least 120 minutes.INTERVENTIONS: Patients were randomly assigned to receive either 1.0 or 2.0 L/min fresh gas flow with the vaporizer setting fixed at 2% sevoflurane. The inspired (In), end-tidal (Et), and Et/In ratio sevoflurane concentrations were estimated.MEASUREMENTS AND MAIN RESULTS: After 120 minutes of sevoflurane anesthesia the inspired and end-tidal sevoflurane concentration were 1.45 +/- 0.10% versus 1.28 +/- 0.12% (p < 0.001) in the 1.0 L/min group and 1.64 +/- 0.08% versus 1.46 +/- 0.11% (p < 0.001) in the 2.0 L/min group. The ratio end-tidal and inspired concentrations/vaporizer setting was 0.64 +/- 0.06 and 0.73 +/- 0.05 in the 1.0 L/min group versus 0.73 +/- 0.05 and 0.82 +/- 0.04 in the 2.0 L/min group. For the ratio inspired and end-tidal/vaporizer setting there were significant difference between the groups (p < 0.001). The estimated ratio end-tidal/inspired was 0.88 +/- 0.04 in the 1.0 L/min group versus 0.89 +/- 0.04 in the 2.0 L/min group (ns).CONCLUSION: After 120 minutes of sevoflurane anesthesia at a vaporizer setting of 2% there is a significant difference between fresh gas flow of 1.0 and 2.0 L/min for inspired and end-tidal concentrations, but not for the ratio end-tidal/inspired. (Less)
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author
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Contribution to journal
publication status
published
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in
Journal of Clinical Anesthesia
volume
14
issue
4
pages
267 - 270
publisher
Elsevier
external identifiers
  • wos:000176583500006
  • pmid:12088809
  • scopus:0036093010
ISSN
1873-4529
DOI
10.1016/S0952-8180(02)00358-6
language
English
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yes
id
793e9f95-6bf6-45c9-9a73-86428a234111 (old id 109068)
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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12088809&dopt=Abstract
date added to LUP
2007-06-28 09:54:08
date last changed
2017-01-15 03:28:59
@article{793e9f95-6bf6-45c9-9a73-86428a234111,
  abstract     = {STUDY OBJECTIVE: To investigate the effect of two different fresh gas flows on inspired and end-tidal sevoflurane concentration for a given vaporizer setting in a low-flow anesthesia system.DESIGN: Prospective clinical study.SETTING: Department of Anesthesiology of a university teaching hospital.PATIENTS: 56 ASA physical status I and II patients without systemic diseases, having elective surgery with an expected anesthesia time of at least 120 minutes.INTERVENTIONS: Patients were randomly assigned to receive either 1.0 or 2.0 L/min fresh gas flow with the vaporizer setting fixed at 2% sevoflurane. The inspired (In), end-tidal (Et), and Et/In ratio sevoflurane concentrations were estimated.MEASUREMENTS AND MAIN RESULTS: After 120 minutes of sevoflurane anesthesia the inspired and end-tidal sevoflurane concentration were 1.45 +/- 0.10% versus 1.28 +/- 0.12% (p &lt; 0.001) in the 1.0 L/min group and 1.64 +/- 0.08% versus 1.46 +/- 0.11% (p &lt; 0.001) in the 2.0 L/min group. The ratio end-tidal and inspired concentrations/vaporizer setting was 0.64 +/- 0.06 and 0.73 +/- 0.05 in the 1.0 L/min group versus 0.73 +/- 0.05 and 0.82 +/- 0.04 in the 2.0 L/min group. For the ratio inspired and end-tidal/vaporizer setting there were significant difference between the groups (p &lt; 0.001). The estimated ratio end-tidal/inspired was 0.88 +/- 0.04 in the 1.0 L/min group versus 0.89 +/- 0.04 in the 2.0 L/min group (ns).CONCLUSION: After 120 minutes of sevoflurane anesthesia at a vaporizer setting of 2% there is a significant difference between fresh gas flow of 1.0 and 2.0 L/min for inspired and end-tidal concentrations, but not for the ratio end-tidal/inspired.},
  author       = {Johansson, Anders and Lundberg, Dag and Luttropp, Hans-Henrik},
  issn         = {1873-4529},
  language     = {eng},
  number       = {4},
  pages        = {267--270},
  publisher    = {Elsevier},
  series       = {Journal of Clinical Anesthesia},
  title        = {The quotient end-tidal/inspired concentration of sevoflurane in a low-flow system.},
  url          = {http://dx.doi.org/10.1016/S0952-8180(02)00358-6},
  volume       = {14},
  year         = {2002},
}