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Kinetics of lung clearance of 99mTc-DTPA in smoking patients with sarcoidosis compared to healthy smokers.

Brådvik, Ingela LU ; Wollmer, Per LU ; Evander, Eva LU ; LárusdÓttir, H; Blom-Bülow, B and Jonson, Björn LU (2002) In Respiratory Medicine 96(5). p.317-321
Abstract
Investigation of lung clearance of 99mTc-labelled diethylene triamine penta-acetic acid (DTPA) in smoking sarcoid patients has been impeded by difficulties to differ between pathology of clearance kinetics caused by sarcoidosis and by smoking. This study explores the kinetics of lung clearance of 99mTc-DTPA in 15 current smokers with intrathoracic sarcoidosis. The results are compared with findings from 16 healthy smokers. Measurements of lung clearance over 180 min, i.e. longer than usual, revealed in II of the sarcoid patients a bi-exponential lung clearance course, which is pathologic. All healthy smokers also showed a bi-exponential lung clearance. In the analysis of the bi-exponential curve an initial fast, and a slow clearance... (More)
Investigation of lung clearance of 99mTc-labelled diethylene triamine penta-acetic acid (DTPA) in smoking sarcoid patients has been impeded by difficulties to differ between pathology of clearance kinetics caused by sarcoidosis and by smoking. This study explores the kinetics of lung clearance of 99mTc-DTPA in 15 current smokers with intrathoracic sarcoidosis. The results are compared with findings from 16 healthy smokers. Measurements of lung clearance over 180 min, i.e. longer than usual, revealed in II of the sarcoid patients a bi-exponential lung clearance course, which is pathologic. All healthy smokers also showed a bi-exponential lung clearance. In the analysis of the bi-exponential curve an initial fast, and a slow clearance component could be separated. The smokers with sarcoidosis had a significantly higher elimination rate of the slow component than the healthy smokers. Thus, analysis of the late part of the lung clearance curve may be rewarding in smoking sarcoid patients. The study shows that lung clearance of 99mTc-DTPA may be a method useful also in smoking patients with sarcoidosis. (Less)
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organization
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Contribution to journal
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published
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keywords
Middle Age, Radiopharmaceuticals : pharmacokinetics, Technetium Tc 99m Pentetate : pharmacokinetics, Non-U.S. Gov't, Support, Spirometry, Smoking : physiopathology, Smoking : metabolism, Pulmonary : physiopathology, Sarcoidosis, Pulmonary : metabolism, Lung : metabolism, Human, Half-Life, Adult, Follow-Up Studies, Forced Expiratory Volume
in
Respiratory Medicine
volume
96
issue
5
pages
317 - 321
publisher
Elsevier
external identifiers
  • pmid:12113381
  • wos:000176651800004
  • scopus:0036586864
ISSN
1532-3064
DOI
10.1053/rmed.2001.1285
language
English
LU publication?
yes
id
3c2dc2b2-9316-42ad-bfc4-52649c4a1e71 (old id 109313)
alternative location
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=12113381&dopt=Abstract
date added to LUP
2007-07-02 13:50:07
date last changed
2017-01-01 07:25:26
@article{3c2dc2b2-9316-42ad-bfc4-52649c4a1e71,
  abstract     = {Investigation of lung clearance of 99mTc-labelled diethylene triamine penta-acetic acid (DTPA) in smoking sarcoid patients has been impeded by difficulties to differ between pathology of clearance kinetics caused by sarcoidosis and by smoking. This study explores the kinetics of lung clearance of 99mTc-DTPA in 15 current smokers with intrathoracic sarcoidosis. The results are compared with findings from 16 healthy smokers. Measurements of lung clearance over 180 min, i.e. longer than usual, revealed in II of the sarcoid patients a bi-exponential lung clearance course, which is pathologic. All healthy smokers also showed a bi-exponential lung clearance. In the analysis of the bi-exponential curve an initial fast, and a slow clearance component could be separated. The smokers with sarcoidosis had a significantly higher elimination rate of the slow component than the healthy smokers. Thus, analysis of the late part of the lung clearance curve may be rewarding in smoking sarcoid patients. The study shows that lung clearance of 99mTc-DTPA may be a method useful also in smoking patients with sarcoidosis.},
  author       = {Brådvik, Ingela and Wollmer, Per and Evander, Eva and LárusdÓttir, H and Blom-Bülow, B and Jonson, Björn},
  issn         = {1532-3064},
  keyword      = {Middle Age,Radiopharmaceuticals : pharmacokinetics,Technetium Tc 99m Pentetate : pharmacokinetics,Non-U.S. Gov't,Support,Spirometry,Smoking : physiopathology,Smoking : metabolism,Pulmonary : physiopathology,Sarcoidosis,Pulmonary : metabolism,Lung : metabolism,Human,Half-Life,Adult,Follow-Up Studies,Forced Expiratory Volume},
  language     = {eng},
  number       = {5},
  pages        = {317--321},
  publisher    = {Elsevier},
  series       = {Respiratory Medicine},
  title        = {Kinetics of lung clearance of 99mTc-DTPA in smoking patients with sarcoidosis compared to healthy smokers.},
  url          = {http://dx.doi.org/10.1053/rmed.2001.1285},
  volume       = {96},
  year         = {2002},
}