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5-y Follow-up study of patients with neuroborreliosis.

Berglund, Johan LU ; Stjernberg, Louise LU ; Ornstein, Katharina LU ; Tykesson-Joelsson, Katarina and Walter, Hallstein (2002) In Scandinavian Journal of Infectious Diseases 34(6). p.421-425
Abstract
The objective of this follow-up study was to determine the long-term outcome of strictly classified cases of neuroborreliosis treated with antibiotics. A 1-y prospective population-based survey of Lyme borreliosis was conducted in southern Sweden between 1992 and 1993. A total of 349 identified cases with suspected neuroborreliosis were followed up 5 y later. Medical records were reviewed and all participants filled in a questionnaire. Of those patients classified with definite neuroborreliosis, 114/130 completed the follow-up, of whom 111 had completed the initial antibiotic treatment. Of the 114 patients followed up, 86 (75%) had recovered completely and 70 (61%) had recovered within 6 months. Residual neurological symptoms, such as... (More)
The objective of this follow-up study was to determine the long-term outcome of strictly classified cases of neuroborreliosis treated with antibiotics. A 1-y prospective population-based survey of Lyme borreliosis was conducted in southern Sweden between 1992 and 1993. A total of 349 identified cases with suspected neuroborreliosis were followed up 5 y later. Medical records were reviewed and all participants filled in a questionnaire. Of those patients classified with definite neuroborreliosis, 114/130 completed the follow-up, of whom 111 had completed the initial antibiotic treatment. Of the 114 patients followed up, 86 (75%) had recovered completely and 70 (61%) had recovered within 6 months. Residual neurological symptoms, such as facial palsy, concentration disorder, paresthesia and/or neuropathy, were reported by 28/114 patients. No significant differences between different antibiotic treatments were observed in terms of the occurrence of sequelae. To conclude, we found that 25% (95% confidence interval 17-33%) of the patients suffered from residual neurological symptoms 5 y post-treatment. However, the clinical outcome of treated neuroborreliosis is favorable as only 14/114 (12%) patients had sequelae that influenced their daily activities post-treatment. Early diagnosis and treatment would seem to be of great importance in order to avoid such sequelae. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Infectious Diseases
volume
34
issue
6
pages
421 - 425
publisher
Informa Healthcare
external identifiers
  • pmid:12160168
  • wos:000177058300005
  • scopus:0035990579
ISSN
1651-1980
DOI
10.1080/00365540110080421
language
English
LU publication?
yes
id
8fdfb752-38e1-486f-9c8d-ba2cbb9393a3 (old id 109733)
alternative location
http://www.informaworld.com/smpp/content?content=10.1080/00365540110080421
date added to LUP
2007-07-12 11:24:02
date last changed
2017-11-19 04:15:57
@article{8fdfb752-38e1-486f-9c8d-ba2cbb9393a3,
  abstract     = {The objective of this follow-up study was to determine the long-term outcome of strictly classified cases of neuroborreliosis treated with antibiotics. A 1-y prospective population-based survey of Lyme borreliosis was conducted in southern Sweden between 1992 and 1993. A total of 349 identified cases with suspected neuroborreliosis were followed up 5 y later. Medical records were reviewed and all participants filled in a questionnaire. Of those patients classified with definite neuroborreliosis, 114/130 completed the follow-up, of whom 111 had completed the initial antibiotic treatment. Of the 114 patients followed up, 86 (75%) had recovered completely and 70 (61%) had recovered within 6 months. Residual neurological symptoms, such as facial palsy, concentration disorder, paresthesia and/or neuropathy, were reported by 28/114 patients. No significant differences between different antibiotic treatments were observed in terms of the occurrence of sequelae. To conclude, we found that 25% (95% confidence interval 17-33%) of the patients suffered from residual neurological symptoms 5 y post-treatment. However, the clinical outcome of treated neuroborreliosis is favorable as only 14/114 (12%) patients had sequelae that influenced their daily activities post-treatment. Early diagnosis and treatment would seem to be of great importance in order to avoid such sequelae.},
  author       = {Berglund, Johan and Stjernberg, Louise and Ornstein, Katharina and Tykesson-Joelsson, Katarina and Walter, Hallstein},
  issn         = {1651-1980},
  language     = {eng},
  number       = {6},
  pages        = {421--425},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Infectious Diseases},
  title        = {5-y Follow-up study of patients with neuroborreliosis.},
  url          = {http://dx.doi.org/10.1080/00365540110080421},
  volume       = {34},
  year         = {2002},
}