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A longitudinal cohort study on the prevalence of Helicobacter pylori antibodies in Swedish children and adolescents.

Granquist, Å; Bredberg, A; Sveger, Tomas LU and Axelsson, Irene LU (2002) In Acta Pædiatrica 91(6). p.636-640
Abstract
The aim of this study was to monitor the Helicobacter pylori antibody seroprevalence of an asymptomatic cohort between the ages of 4 and 18 y. The H. pylori antibody titres in a longitudinally followed cohort of 168 native Swedish children (born between 1972 and 1974) were established at 4, 8, 12, 16, and 18 y of age. Seventeen children (10.1%) were found positive on at least one occasion when a paediatric cut-off was applied. Five children (3.0%) reached levels considered positive in adults. The seroprevalence at 4 y of age was 4.0%, at 8 y 2.5%, at 12 y 4.9%, at 16 y 5.3%, and at 18 y 6.3%. The difference in serological titres between the age groups was not significant. A change from negative to positive after the age of 4 took place in... (More)
The aim of this study was to monitor the Helicobacter pylori antibody seroprevalence of an asymptomatic cohort between the ages of 4 and 18 y. The H. pylori antibody titres in a longitudinally followed cohort of 168 native Swedish children (born between 1972 and 1974) were established at 4, 8, 12, 16, and 18 y of age. Seventeen children (10.1%) were found positive on at least one occasion when a paediatric cut-off was applied. Five children (3.0%) reached levels considered positive in adults. The seroprevalence at 4 y of age was 4.0%, at 8 y 2.5%, at 12 y 4.9%, at 16 y 5.3%, and at 18 y 6.3%. The difference in serological titres between the age groups was not significant. A change from negative to positive after the age of 4 took place in 5 of the cases. Spontaneous seroreversion appeared in 5 cases. CONCLUSION: Our findings showed no significant differences among the various age groups. Seventeen of the 168 children (10.1%) had been infected at some time, the prevalence ranging from 2.5% to 6.3%. Seroconversion and seroreversion occurred infrequently between the ages of 4 and 18 y. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Pædiatrica
volume
91
issue
6
pages
636 - 640
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • wos:000176674400005
  • pmid:12162593
  • scopus:0036066698
ISSN
1651-2227
DOI
10.1080/080352502760069025
language
English
LU publication?
yes
id
d6b92d14-a8e8-47ba-887a-e73f24dc4299 (old id 109755)
date added to LUP
2007-07-20 15:28:54
date last changed
2017-01-01 06:52:40
@article{d6b92d14-a8e8-47ba-887a-e73f24dc4299,
  abstract     = {The aim of this study was to monitor the Helicobacter pylori antibody seroprevalence of an asymptomatic cohort between the ages of 4 and 18 y. The H. pylori antibody titres in a longitudinally followed cohort of 168 native Swedish children (born between 1972 and 1974) were established at 4, 8, 12, 16, and 18 y of age. Seventeen children (10.1%) were found positive on at least one occasion when a paediatric cut-off was applied. Five children (3.0%) reached levels considered positive in adults. The seroprevalence at 4 y of age was 4.0%, at 8 y 2.5%, at 12 y 4.9%, at 16 y 5.3%, and at 18 y 6.3%. The difference in serological titres between the age groups was not significant. A change from negative to positive after the age of 4 took place in 5 of the cases. Spontaneous seroreversion appeared in 5 cases. CONCLUSION: Our findings showed no significant differences among the various age groups. Seventeen of the 168 children (10.1%) had been infected at some time, the prevalence ranging from 2.5% to 6.3%. Seroconversion and seroreversion occurred infrequently between the ages of 4 and 18 y.},
  author       = {Granquist, Å and Bredberg, A and Sveger, Tomas and Axelsson, Irene},
  issn         = {1651-2227},
  language     = {eng},
  number       = {6},
  pages        = {636--640},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Acta Pædiatrica},
  title        = {A longitudinal cohort study on the prevalence of Helicobacter pylori antibodies in Swedish children and adolescents.},
  url          = {http://dx.doi.org/10.1080/080352502760069025},
  volume       = {91},
  year         = {2002},
}