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Nociceptive inhibition of withdrawal reflex responses increases over time in spinalized rats

Weng, Han Rong and Schouenborg, Jens LU (1996) In NeuroReport 7(7). p.1310-1314
Abstract

Time-dependent changes of nociceptive inhibition of hindlimb withdrawal reflex (WR) pathways were investigated in acute decerebrate spinal rats. Electromyographic recordings of WR of peroneus longus and extensor digitorum longus muscles were made. For each muscle, both short and long latency WR evoked by subcutaneous electrical stimulation and WR evoked by noxious pinch could be inhibited by noxious CO2 laser stimulation of a specific skin area of the ipsilateral hindlimb. The inhibitory effects and size of the inhibitory receptive fields increased spontaneously between two- and three- fold during the first 12 h after spinalization. The functional and possible clinical significance of the strengthened nociceptive inhibitory... (More)

Time-dependent changes of nociceptive inhibition of hindlimb withdrawal reflex (WR) pathways were investigated in acute decerebrate spinal rats. Electromyographic recordings of WR of peroneus longus and extensor digitorum longus muscles were made. For each muscle, both short and long latency WR evoked by subcutaneous electrical stimulation and WR evoked by noxious pinch could be inhibited by noxious CO2 laser stimulation of a specific skin area of the ipsilateral hindlimb. The inhibitory effects and size of the inhibitory receptive fields increased spontaneously between two- and three- fold during the first 12 h after spinalization. The functional and possible clinical significance of the strengthened nociceptive inhibitory control and mechanisms underlying the changes of this control after spinal transection are discussed.

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type
Contribution to journal
publication status
published
subject
keywords
Analgesia, Hyperreflexia, Pain, Spinal cord injuries
in
NeuroReport
volume
7
issue
7
pages
1310 - 1314
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:8817556
  • scopus:0029680359
ISSN
0959-4965
DOI
10.1097/00001756-199605170-00019
language
English
LU publication?
yes
id
109ed723-4d3f-4acf-a466-1109d7e8392d
date added to LUP
2019-06-25 15:49:08
date last changed
2020-01-13 02:07:12
@article{109ed723-4d3f-4acf-a466-1109d7e8392d,
  abstract     = {<p>Time-dependent changes of nociceptive inhibition of hindlimb withdrawal reflex (WR) pathways were investigated in acute decerebrate spinal rats. Electromyographic recordings of WR of peroneus longus and extensor digitorum longus muscles were made. For each muscle, both short and long latency WR evoked by subcutaneous electrical stimulation and WR evoked by noxious pinch could be inhibited by noxious CO<sub>2</sub> laser stimulation of a specific skin area of the ipsilateral hindlimb. The inhibitory effects and size of the inhibitory receptive fields increased spontaneously between two- and three- fold during the first 12 h after spinalization. The functional and possible clinical significance of the strengthened nociceptive inhibitory control and mechanisms underlying the changes of this control after spinal transection are discussed.</p>},
  author       = {Weng, Han Rong and Schouenborg, Jens},
  issn         = {0959-4965},
  language     = {eng},
  number       = {7},
  pages        = {1310--1314},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {NeuroReport},
  title        = {Nociceptive inhibition of withdrawal reflex responses increases over time in spinalized rats},
  url          = {http://dx.doi.org/10.1097/00001756-199605170-00019},
  doi          = {10.1097/00001756-199605170-00019},
  volume       = {7},
  year         = {1996},
}