Identification of an HLA-DQ β-chain related genomic sequence associated with insulin-dependent diabetes
Michelsen, B. ; Kastern, W. ; Lernmark, A. LU
and Owerbach, D.
(1985)
In Biomedica Biochimica Acta
44(1).
p.33-36
- Abstract
Restriction fragment length polymorphism detected by a cDNA probe for an HLA-DQ β-chain gene has revealed an HLA-DR4 linked BamH1 3.7 kb fragment which is rarely found among insulin-dependent diabetic patients. The present analysis demonstrates that the BamH1 3.7 kb fragment present on an HLA-DR4 positive chromosome in a healthy individual contains coding sequences for an HLA-DQ β-chain gene and that the absence of this fragment among HLA-DR4 positive insulin-dependent patients is due to the loss of a BamH1 restriction within an intervening sequence.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/10b1979c-6674-45e2-bdef-455b4fb45920
- author
- Michelsen, B.
; Kastern, W.
; Lernmark, A.
LU
and Owerbach, D.
- publishing date
- 1985-01-01
- type
- Contribution to journal
- publication status
- published
- in
- Biomedica Biochimica Acta
- volume
- 44
- issue
- 1
- pages
- 4 pages
- publisher
- Akademie Verlag GMBH
- external identifiers
-
- scopus:0021951527
- pmid:2986612
- ISSN
- 0232-766X
- language
- English
- LU publication?
- no
- id
- 10b1979c-6674-45e2-bdef-455b4fb45920
- date added to LUP
- 2019-09-16 12:38:15
- date last changed
- 2025-01-09 22:51:24
@article{10b1979c-6674-45e2-bdef-455b4fb45920,
abstract = {{<p>Restriction fragment length polymorphism detected by a cDNA probe for an HLA-DQ β-chain gene has revealed an HLA-DR4 linked BamH1 3.7 kb fragment which is rarely found among insulin-dependent diabetic patients. The present analysis demonstrates that the BamH1 3.7 kb fragment present on an HLA-DR4 positive chromosome in a healthy individual contains coding sequences for an HLA-DQ β-chain gene and that the absence of this fragment among HLA-DR4 positive insulin-dependent patients is due to the loss of a BamH1 restriction within an intervening sequence.</p>}},
author = {{Michelsen, B. and Kastern, W. and Lernmark, A. and Owerbach, D.}},
issn = {{0232-766X}},
language = {{eng}},
month = {{01}},
number = {{1}},
pages = {{33--36}},
publisher = {{Akademie Verlag GMBH}},
series = {{Biomedica Biochimica Acta}},
title = {{Identification of an HLA-DQ β-chain related genomic sequence associated with insulin-dependent diabetes}},
volume = {{44}},
year = {{1985}},
}