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Power Cut : Inhibiting Mitochondrial Translation to Target Leukemia

Järås, Marcus LU and Ebert, Benjamin L. (2011) In Cancer Cell 20(5). p.555-556
Abstract

In this issue of Cancer Cell, Skrtic et al. demonstrate that inhibition of mitochondrial ribosomes with tigecycline, a known antimicrobial, selectively kills leukemia cells. This finding highlights the metabolic susceptibility of leukemia cells to mitochondrial translational inhibition and identifies a compound with significant efficacy in an in vivo preclinical model.

Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer Cell
volume
20
issue
5
pages
2 pages
publisher
Cell Press
external identifiers
  • scopus:81255189528
ISSN
1535-6108
DOI
10.1016/j.ccr.2011.10.028
language
English
LU publication?
no
id
10b2b617-de7a-4447-a158-e86750846e84
date added to LUP
2017-09-05 12:06:58
date last changed
2017-09-05 12:06:58
@article{10b2b617-de7a-4447-a158-e86750846e84,
  abstract     = {<p>In this issue of Cancer Cell, Skrtic et al. demonstrate that inhibition of mitochondrial ribosomes with tigecycline, a known antimicrobial, selectively kills leukemia cells. This finding highlights the metabolic susceptibility of leukemia cells to mitochondrial translational inhibition and identifies a compound with significant efficacy in an in vivo preclinical model.</p>},
  author       = {Järås, Marcus and Ebert, Benjamin L.},
  issn         = {1535-6108},
  language     = {eng},
  month        = {11},
  number       = {5},
  pages        = {555--556},
  publisher    = {Cell Press},
  series       = {Cancer Cell},
  title        = {Power Cut : Inhibiting Mitochondrial Translation to Target Leukemia},
  url          = {http://dx.doi.org/10.1016/j.ccr.2011.10.028},
  volume       = {20},
  year         = {2011},
}