Power Cut : Inhibiting Mitochondrial Translation to Target Leukemia
(2011) In Cancer Cell 20(5). p.555-556- Abstract
In this issue of Cancer Cell, Skrtic et al. demonstrate that inhibition of mitochondrial ribosomes with tigecycline, a known antimicrobial, selectively kills leukemia cells. This finding highlights the metabolic susceptibility of leukemia cells to mitochondrial translational inhibition and identifies a compound with significant efficacy in an in vivo preclinical model.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/10b2b617-de7a-4447-a158-e86750846e84
- author
- Järås, Marcus LU and Ebert, Benjamin L.
- publishing date
- 2011-11-15
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cancer Cell
- volume
- 20
- issue
- 5
- pages
- 2 pages
- publisher
- Cell Press
- external identifiers
-
- scopus:81255189528
- ISSN
- 1535-6108
- DOI
- 10.1016/j.ccr.2011.10.028
- language
- English
- LU publication?
- no
- id
- 10b2b617-de7a-4447-a158-e86750846e84
- date added to LUP
- 2017-09-05 12:06:58
- date last changed
- 2022-01-30 22:36:14
@article{10b2b617-de7a-4447-a158-e86750846e84,
abstract = {{<p>In this issue of Cancer Cell, Skrtic et al. demonstrate that inhibition of mitochondrial ribosomes with tigecycline, a known antimicrobial, selectively kills leukemia cells. This finding highlights the metabolic susceptibility of leukemia cells to mitochondrial translational inhibition and identifies a compound with significant efficacy in an in vivo preclinical model.</p>}},
author = {{Järås, Marcus and Ebert, Benjamin L.}},
issn = {{1535-6108}},
language = {{eng}},
month = {{11}},
number = {{5}},
pages = {{555--556}},
publisher = {{Cell Press}},
series = {{Cancer Cell}},
title = {{Power Cut : Inhibiting Mitochondrial Translation to Target Leukemia}},
url = {{http://dx.doi.org/10.1016/j.ccr.2011.10.028}},
doi = {{10.1016/j.ccr.2011.10.028}},
volume = {{20}},
year = {{2011}},
}