Body mass index and risk of malignant lymphoma in Scandinavian men and women
(2005) In Journal of the National Cancer Institute 97(3). p.210-218- Abstract
- Background. The incidence of non-Hodgkin lymphoma and prevalence of obesity are increasing globally. A suggested positive association between obesity and risk of non-Hodgkin lymphoma has prompted us to investigate the relationship between body mass index (BMI) and risk of malignant lymphoma subtypes in a population-based case-control study. Methods: Telephone interviews were conducted with 3055 case patients with non-Hodgkin lymphoma and 618 case patients with Hodgkin lymphoma diagnosed between October 1, 1999, and August 30, 2002, and 3187 population-based control subjects. The interviews assessed current height, normal adult weight, and other possible risk factors. Multivariable odds ratios (ORs) and corresponding 95% confidence... (More)
- Background. The incidence of non-Hodgkin lymphoma and prevalence of obesity are increasing globally. A suggested positive association between obesity and risk of non-Hodgkin lymphoma has prompted us to investigate the relationship between body mass index (BMI) and risk of malignant lymphoma subtypes in a population-based case-control study. Methods: Telephone interviews were conducted with 3055 case patients with non-Hodgkin lymphoma and 618 case patients with Hodgkin lymphoma diagnosed between October 1, 1999, and August 30, 2002, and 3187 population-based control subjects. The interviews assessed current height, normal adult weight, and other possible risk factors. Multivariable odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for risk of lymphoma were estimated by unconditional logistic regression. All statistical tests were two-sided. Results: BMI was not associated with risk of overall non-Hodgkin lymphoma or of Hodgkin lymphoma (for example, comparing the highly obese group [BMI greater than or equal to35.0 kg/m(2)] with the normal-weight group [BMI = 18.5-24.9 kg/m(2)], OR for risk of non-Hodgkin lymphoma = 0.9, 95% CI = 0.6 to 1.3; P-trend across all categories of BMI = .27). BMI was also not associated with risk of any non-Hodgkin lymphoma subtype evaluated, although there was some evidence of a positive association with risk of diffuse large B-cell lymphoma (for example, comparing the highly obese group with the normal-weight group, OR for diffuse large B-cell lymphoma = 1.5, 95% CI = 0.9 to 2.4; P-trend = .05). Conclusions: Excess weight does not appear to be associated with an increased risk of malignant lymphoma in general, or with a risk of most major lymphoma subtypes. Hence, the growing incidence of obesity is unlikely to be an important contributor to the increasing incidence of non-Hodgkin lymphoma worldwide. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/254272
- author
- Chang, E T ; Hjalgrim, H ; Smedby, K E ; Åkerman, Måns LU ; Tani, E ; Johnsen, H E ; Glimelius, B ; Adami, H O and Melbye, M
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of the National Cancer Institute
- volume
- 97
- issue
- 3
- pages
- 210 - 218
- publisher
- Oxford University Press
- external identifiers
-
- wos:000226748200012
- pmid:15687364
- scopus:13744263345
- ISSN
- 1460-2105
- DOI
- 10.1093/jnci/dji012
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000)
- id
- 10c51c9c-14c1-4781-8fee-6602f2a7e1d7 (old id 254272)
- date added to LUP
- 2016-04-01 16:57:57
- date last changed
- 2022-01-28 23:22:56
@article{10c51c9c-14c1-4781-8fee-6602f2a7e1d7,
abstract = {{Background. The incidence of non-Hodgkin lymphoma and prevalence of obesity are increasing globally. A suggested positive association between obesity and risk of non-Hodgkin lymphoma has prompted us to investigate the relationship between body mass index (BMI) and risk of malignant lymphoma subtypes in a population-based case-control study. Methods: Telephone interviews were conducted with 3055 case patients with non-Hodgkin lymphoma and 618 case patients with Hodgkin lymphoma diagnosed between October 1, 1999, and August 30, 2002, and 3187 population-based control subjects. The interviews assessed current height, normal adult weight, and other possible risk factors. Multivariable odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for risk of lymphoma were estimated by unconditional logistic regression. All statistical tests were two-sided. Results: BMI was not associated with risk of overall non-Hodgkin lymphoma or of Hodgkin lymphoma (for example, comparing the highly obese group [BMI greater than or equal to35.0 kg/m(2)] with the normal-weight group [BMI = 18.5-24.9 kg/m(2)], OR for risk of non-Hodgkin lymphoma = 0.9, 95% CI = 0.6 to 1.3; P-trend across all categories of BMI = .27). BMI was also not associated with risk of any non-Hodgkin lymphoma subtype evaluated, although there was some evidence of a positive association with risk of diffuse large B-cell lymphoma (for example, comparing the highly obese group with the normal-weight group, OR for diffuse large B-cell lymphoma = 1.5, 95% CI = 0.9 to 2.4; P-trend = .05). Conclusions: Excess weight does not appear to be associated with an increased risk of malignant lymphoma in general, or with a risk of most major lymphoma subtypes. Hence, the growing incidence of obesity is unlikely to be an important contributor to the increasing incidence of non-Hodgkin lymphoma worldwide.}},
author = {{Chang, E T and Hjalgrim, H and Smedby, K E and Åkerman, Måns and Tani, E and Johnsen, H E and Glimelius, B and Adami, H O and Melbye, M}},
issn = {{1460-2105}},
language = {{eng}},
number = {{3}},
pages = {{210--218}},
publisher = {{Oxford University Press}},
series = {{Journal of the National Cancer Institute}},
title = {{Body mass index and risk of malignant lymphoma in Scandinavian men and women}},
url = {{http://dx.doi.org/10.1093/jnci/dji012}},
doi = {{10.1093/jnci/dji012}},
volume = {{97}},
year = {{2005}},
}