Increased blood-brain barrier permeability of morphine in a patient with severe brain lesions as determined by microdialysis
(2001) In Acta Anaesthesiologica Scandinavica 45(3). p.390-392- Abstract
- Intracerebral microdialysis was utilised to obtain information regarding how morphine is transported across the blood-brain barrier (BBB). In a patient with a severe brain injury, we measured simultaneously unbound extracellular fluid (ECF) concentrations of morphine in human brain and in subcutaneous fat tissue, which were compared to morphine levels in arterial blood. This report shows an increase in morphine levels near the trauma site in the brain compared to uninjured brain tissue. The half-life of morphine in uninjured and injured brain tissue of 178 min and 169 min, respectively, were comparable but were longer than in blood (64 min) and adipose tissue (63 min). This indicates that morphine is retained in brain tissue for a longer... (More)
- Intracerebral microdialysis was utilised to obtain information regarding how morphine is transported across the blood-brain barrier (BBB). In a patient with a severe brain injury, we measured simultaneously unbound extracellular fluid (ECF) concentrations of morphine in human brain and in subcutaneous fat tissue, which were compared to morphine levels in arterial blood. This report shows an increase in morphine levels near the trauma site in the brain compared to uninjured brain tissue. The half-life of morphine in uninjured and injured brain tissue of 178 min and 169 min, respectively, were comparable but were longer than in blood (64 min) and adipose tissue (63 min). This indicates that morphine is retained in brain tissue for a longer time than what could be expected from the blood concentration-time profile. These results show the potential of the microdialysis technique in providing new information regarding the pharmacokinetics of drug in the human brain close to the trauma site and in macroscopically intact tissue. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1119539
- author
- Bouw, R. ; Ederoth, Per LU ; Lundberg, Johan LU ; Ungerstedt, U. ; Nordström, Carl-Henrik LU and Hammarlund-Udenaes, M.
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Anaesthesiologica Scandinavica
- volume
- 45
- issue
- 3
- pages
- 390 - 392
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000167243900019
- scopus:0035129778
- ISSN
- 0001-5172
- DOI
- 10.1034/j.1399-6576.2001.045003390.x
- language
- English
- LU publication?
- yes
- id
- 10c974cc-07bb-4369-87d0-da99761b97f4 (old id 1119539)
- date added to LUP
- 2016-04-01 12:12:20
- date last changed
- 2022-04-29 02:07:02
@article{10c974cc-07bb-4369-87d0-da99761b97f4,
abstract = {{Intracerebral microdialysis was utilised to obtain information regarding how morphine is transported across the blood-brain barrier (BBB). In a patient with a severe brain injury, we measured simultaneously unbound extracellular fluid (ECF) concentrations of morphine in human brain and in subcutaneous fat tissue, which were compared to morphine levels in arterial blood. This report shows an increase in morphine levels near the trauma site in the brain compared to uninjured brain tissue. The half-life of morphine in uninjured and injured brain tissue of 178 min and 169 min, respectively, were comparable but were longer than in blood (64 min) and adipose tissue (63 min). This indicates that morphine is retained in brain tissue for a longer time than what could be expected from the blood concentration-time profile. These results show the potential of the microdialysis technique in providing new information regarding the pharmacokinetics of drug in the human brain close to the trauma site and in macroscopically intact tissue.}},
author = {{Bouw, R. and Ederoth, Per and Lundberg, Johan and Ungerstedt, U. and Nordström, Carl-Henrik and Hammarlund-Udenaes, M.}},
issn = {{0001-5172}},
language = {{eng}},
number = {{3}},
pages = {{390--392}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Anaesthesiologica Scandinavica}},
title = {{Increased blood-brain barrier permeability of morphine in a patient with severe brain lesions as determined by microdialysis}},
url = {{http://dx.doi.org/10.1034/j.1399-6576.2001.045003390.x}},
doi = {{10.1034/j.1399-6576.2001.045003390.x}},
volume = {{45}},
year = {{2001}},
}