Neutrophil extracellular traps - The dark side of neutrophils
(2016) In Journal of Clinical Investigation 126(5). p.1612-1620- Abstract
Neutrophil extracellular traps (NETs) were discovered as extracellular strands of decondensed DNA in complex with histones and granule proteins, which were expelled from dying neutrophils to ensnare and kill microbes. NETs are formed during infection in vivo by mechanisms different from those originally described in vitro. Citrullination of histones by peptidyl arginine deiminase 4 (PAD4) is central for NET formation in vivo. NETs may spur formation of autoantibodies and may also serve as scaffolds for thrombosis, thereby providing a link among infection, autoimmunity, and thrombosis. In this review, we present the mechanisms by which NETs are formed and discuss the physiological and pathophysiological consequences of NET formation. We... (More)
Neutrophil extracellular traps (NETs) were discovered as extracellular strands of decondensed DNA in complex with histones and granule proteins, which were expelled from dying neutrophils to ensnare and kill microbes. NETs are formed during infection in vivo by mechanisms different from those originally described in vitro. Citrullination of histones by peptidyl arginine deiminase 4 (PAD4) is central for NET formation in vivo. NETs may spur formation of autoantibodies and may also serve as scaffolds for thrombosis, thereby providing a link among infection, autoimmunity, and thrombosis. In this review, we present the mechanisms by which NETs are formed and discuss the physiological and pathophysiological consequences of NET formation. We conclude that NETs may be of more importance in autoimmunity and thrombosis than in innate immune defense.
(Less)
- author
- Sørensen, Ole E. LU and Borregaard, Niels
- organization
- publishing date
- 2016-05-02
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Clinical Investigation
- volume
- 126
- issue
- 5
- pages
- 9 pages
- publisher
- American Society for Clinical Investigation
- external identifiers
-
- pmid:27135878
- wos:000375182100002
- scopus:84988470876
- ISSN
- 0021-9738
- DOI
- 10.1172/JCI84538
- language
- English
- LU publication?
- yes
- id
- 10e1024e-887b-485a-9a2c-569084e0bdb7
- date added to LUP
- 2016-11-03 14:37:46
- date last changed
- 2025-03-09 22:12:40
@article{10e1024e-887b-485a-9a2c-569084e0bdb7,
abstract = {{<p>Neutrophil extracellular traps (NETs) were discovered as extracellular strands of decondensed DNA in complex with histones and granule proteins, which were expelled from dying neutrophils to ensnare and kill microbes. NETs are formed during infection in vivo by mechanisms different from those originally described in vitro. Citrullination of histones by peptidyl arginine deiminase 4 (PAD4) is central for NET formation in vivo. NETs may spur formation of autoantibodies and may also serve as scaffolds for thrombosis, thereby providing a link among infection, autoimmunity, and thrombosis. In this review, we present the mechanisms by which NETs are formed and discuss the physiological and pathophysiological consequences of NET formation. We conclude that NETs may be of more importance in autoimmunity and thrombosis than in innate immune defense.</p>}},
author = {{Sørensen, Ole E. and Borregaard, Niels}},
issn = {{0021-9738}},
language = {{eng}},
month = {{05}},
number = {{5}},
pages = {{1612--1620}},
publisher = {{American Society for Clinical Investigation}},
series = {{Journal of Clinical Investigation}},
title = {{Neutrophil extracellular traps - The dark side of neutrophils}},
url = {{http://dx.doi.org/10.1172/JCI84538}},
doi = {{10.1172/JCI84538}},
volume = {{126}},
year = {{2016}},
}