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α-l-FucosyItransferases in Human Serum from Donors of Different ABO, Secretor and Lewis Blood-Group Phenotypes

Schenkel-Brunner, Helmut; Chester, Alan LU and Watkins, Winifred M (1972) In European Journal of Biochemistry 30(2). p.269-277
Abstract
The presence of α-l-fucosyltransferases in human serum of different ABO, secretor and Lewis blood-group phenotypes was investigated with guanosine diphosphate fucose as the sugar donor and low-molecular-weight oligosaccharides, or a macromolecular glycoprotein, as acceptors. In contrast to the α-2-l-fucosyltransferases in human milk, submaxillary glands and stomach mucosa that occur only in ABH secretors, an enzyme that transfers l-fucose to the C-2 position of non-reducing β-galactosyl residues was found in the serum of all normal ABO donors irrespective of their ABH secretor-nonsecretor status. The only sera in which the α-2-l-fucosyltransferase was not demonstrable were three examples of the blood group Bombay Oh phenotype and one... (More)
The presence of α-l-fucosyltransferases in human serum of different ABO, secretor and Lewis blood-group phenotypes was investigated with guanosine diphosphate fucose as the sugar donor and low-molecular-weight oligosaccharides, or a macromolecular glycoprotein, as acceptors. In contrast to the α-2-l-fucosyltransferases in human milk, submaxillary glands and stomach mucosa that occur only in ABH secretors, an enzyme that transfers l-fucose to the C-2 position of non-reducing β-galactosyl residues was found in the serum of all normal ABO donors irrespective of their ABH secretor-nonsecretor status. The only sera in which the α-2-l-fucosyltransferase was not demonstrable were three examples of the blood group Bombay Oh phenotype and one example of the Bh phenotype. An a-3-l-fucosyltransferase that conveyed L-fucose to the C-3 position in N-acetyl-d-glucosamine or d-glucose occurred in all the sera examined including those from donors of the Bombay Oh and Bh phenotypes. a-4-l-Fucosyltransferase activity was virtually absent from the sera, irrespective of the Lewis blood group of the donors. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Biochemistry
volume
30
issue
2
pages
269 - 277
publisher
Wiley-Blackwell
external identifiers
  • pmid:4663380
  • scopus:0015406955
ISSN
0014-2956
DOI
10.1111/j.1432-1033.1972.tb02095.x
language
English
LU publication?
no
id
69293be7-86f6-424b-91bb-a53d91b6a7b4 (old id 1102560)
date added to LUP
2008-08-14 13:51:33
date last changed
2017-08-06 04:25:53
@article{69293be7-86f6-424b-91bb-a53d91b6a7b4,
  abstract     = {The presence of α-l-fucosyltransferases in human serum of different ABO, secretor and Lewis blood-group phenotypes was investigated with guanosine diphosphate fucose as the sugar donor and low-molecular-weight oligosaccharides, or a macromolecular glycoprotein, as acceptors. In contrast to the α-2-l-fucosyltransferases in human milk, submaxillary glands and stomach mucosa that occur only in ABH secretors, an enzyme that transfers l-fucose to the C-2 position of non-reducing β-galactosyl residues was found in the serum of all normal ABO donors irrespective of their ABH secretor-nonsecretor status. The only sera in which the α-2-l-fucosyltransferase was not demonstrable were three examples of the blood group Bombay Oh phenotype and one example of the Bh phenotype. An a-3-l-fucosyltransferase that conveyed L-fucose to the C-3 position in N-acetyl-d-glucosamine or d-glucose occurred in all the sera examined including those from donors of the Bombay Oh and Bh phenotypes. a-4-l-Fucosyltransferase activity was virtually absent from the sera, irrespective of the Lewis blood group of the donors.},
  author       = {Schenkel-Brunner, Helmut and Chester, Alan and Watkins, Winifred M},
  issn         = {0014-2956},
  language     = {eng},
  number       = {2},
  pages        = {269--277},
  publisher    = {Wiley-Blackwell},
  series       = {European Journal of Biochemistry},
  title        = {α-l-FucosyItransferases in Human Serum from Donors of Different ABO, Secretor and Lewis Blood-Group Phenotypes},
  url          = {http://dx.doi.org/10.1111/j.1432-1033.1972.tb02095.x},
  volume       = {30},
  year         = {1972},
}