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Alterations of lipid metabolism in healthy volunteers during long-term ethanol intake

Belfrage, Per LU ; Berg, Bertel; Hägerstrand, Inga; Nilsson-Ehle, Peter LU ; Tornqvist, Hans and Wiebe, Thomas LU (1977) In European Journal of Clinical Investigation 7(2). p.127-131
Abstract
Nine young, healthy male volunteers were given ethanol (75 g/day) for 5 weeks. The ethanol was divided into five daily doses and taken so that blood ethanol levels never exceeded 0.04% (w/v). During the latter part of the ethanol intake period, there was a significant, transient increase of plasma triglyceride (TG) concentrations followed by reduction to normal levels. A three-fold increase of lipoprotein lipase activity (LLA) occurred in biopsy specimens of adipose tissue. An increase of alpha-lipoprotein concentrations, which correlated significantly with the decrease in plasma TG levels and the increase in adipose LLA, was also observed during the ethanol intake period. No changes were observed in plasma cholesterol and beta-lipoprotein... (More)
Nine young, healthy male volunteers were given ethanol (75 g/day) for 5 weeks. The ethanol was divided into five daily doses and taken so that blood ethanol levels never exceeded 0.04% (w/v). During the latter part of the ethanol intake period, there was a significant, transient increase of plasma triglyceride (TG) concentrations followed by reduction to normal levels. A three-fold increase of lipoprotein lipase activity (LLA) occurred in biopsy specimens of adipose tissue. An increase of alpha-lipoprotein concentrations, which correlated significantly with the decrease in plasma TG levels and the increase in adipose LLA, was also observed during the ethanol intake period. No changes were observed in plasma cholesterol and beta-lipoprotein levels. A transient, three-fold increase of TG concentrations occurred in liver biopsy specimens. Ultrastructural and cytochemical examinations of the biopsy specimens showed hyperplasia of the smooth endoplasmic reticulum, and increased canallicular activity of gamma-glutamyl transferase (gamma-GT) activity in most subjects towards the end of and after the ethanol intake period. Serum gamma-GT levels also increased significantly. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Ethanol, prolonged daily intake, plasma lipids, lipoprotein lipase activity, adipose tissue, liver lipids, liver ultrastructure, enzyme cytochemistry
in
European Journal of Clinical Investigation
volume
7
issue
2
pages
127 - 131
publisher
Wiley-Blackwell
external identifiers
  • pmid:15844
  • scopus:0017610202
ISSN
0014-2972
DOI
10.1111/j.1365-2362.1977.tb01584.x
language
English
LU publication?
yes
id
24988c93-bd2f-4b7f-8f4a-a58eebfb97c4 (old id 1102644)
date added to LUP
2008-08-14 11:25:10
date last changed
2017-08-06 03:31:00
@article{24988c93-bd2f-4b7f-8f4a-a58eebfb97c4,
  abstract     = {Nine young, healthy male volunteers were given ethanol (75 g/day) for 5 weeks. The ethanol was divided into five daily doses and taken so that blood ethanol levels never exceeded 0.04% (w/v). During the latter part of the ethanol intake period, there was a significant, transient increase of plasma triglyceride (TG) concentrations followed by reduction to normal levels. A three-fold increase of lipoprotein lipase activity (LLA) occurred in biopsy specimens of adipose tissue. An increase of alpha-lipoprotein concentrations, which correlated significantly with the decrease in plasma TG levels and the increase in adipose LLA, was also observed during the ethanol intake period. No changes were observed in plasma cholesterol and beta-lipoprotein levels. A transient, three-fold increase of TG concentrations occurred in liver biopsy specimens. Ultrastructural and cytochemical examinations of the biopsy specimens showed hyperplasia of the smooth endoplasmic reticulum, and increased canallicular activity of gamma-glutamyl transferase (gamma-GT) activity in most subjects towards the end of and after the ethanol intake period. Serum gamma-GT levels also increased significantly.},
  author       = {Belfrage, Per and Berg, Bertel and Hägerstrand, Inga and Nilsson-Ehle, Peter and Tornqvist, Hans and Wiebe, Thomas},
  issn         = {0014-2972},
  keyword      = {Ethanol,prolonged daily intake,plasma lipids,lipoprotein lipase activity,adipose tissue,liver lipids,liver ultrastructure,enzyme cytochemistry},
  language     = {eng},
  number       = {2},
  pages        = {127--131},
  publisher    = {Wiley-Blackwell},
  series       = {European Journal of Clinical Investigation},
  title        = {Alterations of lipid metabolism in healthy volunteers during long-term ethanol intake},
  url          = {http://dx.doi.org/10.1111/j.1365-2362.1977.tb01584.x},
  volume       = {7},
  year         = {1977},
}