Advanced

Interferon production in glia and glioma cell lines

Larsson, Inger; Landström, Lars-Erik; Larner, Ebba; Lundgren, Erik; Miörner, Håkan LU and Strannegård, Örjan (1978) In Infection and Immunity 22(3). p.786-789
Abstract
Interferon (IF) was produced in glia and glioma cell lines in titers comparable to those produced by human fibroblasts. It was inducible by both Sendai virus and polyriboinosinic:polyribocytidylic acid. "Superinduction" resulted in up to 500-fold-higher titers of IF. The IF appeared to be of the fibroblast type, as revealed by experiments using heat treatment, assay of antiviral activity in heterologous cell lines, and neutralization with specific antisera. Since large amounts of IF may easily be produced with glioma cell lines, such cells may be suitable for mass production of IF.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Infection and Immunity
volume
22
issue
3
pages
786 - 789
publisher
American Society for Microbiology
external identifiers
  • pmid:730383
  • scopus:0018219932
ISSN
1098-5522
language
English
LU publication?
yes
id
de817ebe-d0d7-4d14-983b-f239741588c6 (old id 1102677)
alternative location
http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=422229&blobtype=pdf
date added to LUP
2008-08-14 10:55:57
date last changed
2017-07-30 03:42:32
@article{de817ebe-d0d7-4d14-983b-f239741588c6,
  abstract     = {Interferon (IF) was produced in glia and glioma cell lines in titers comparable to those produced by human fibroblasts. It was inducible by both Sendai virus and polyriboinosinic:polyribocytidylic acid. "Superinduction" resulted in up to 500-fold-higher titers of IF. The IF appeared to be of the fibroblast type, as revealed by experiments using heat treatment, assay of antiviral activity in heterologous cell lines, and neutralization with specific antisera. Since large amounts of IF may easily be produced with glioma cell lines, such cells may be suitable for mass production of IF.},
  author       = {Larsson, Inger and Landström, Lars-Erik and Larner, Ebba and Lundgren, Erik and Miörner, Håkan and Strannegård, Örjan},
  issn         = {1098-5522},
  language     = {eng},
  number       = {3},
  pages        = {786--789},
  publisher    = {American Society for Microbiology},
  series       = {Infection and Immunity},
  title        = {Interferon production in glia and glioma cell lines},
  volume       = {22},
  year         = {1978},
}