Modulation of immune responses in newborn and adult mice by interferon
(1978) In Infection and Immunity 20(2). p.334-339- Abstract
- Interferon was found to have both suppressive and enhancing effects on the antibody response in newborn and adult mice. Evidence was obtained that these effects are primarily evoked during the initial steps controlling cell proliferation. Stimulation of thymus and spleen cells with a T-cell mitogen was enhanced by low doses and suppressed by high doses of interferon. Treatment of parental spleen cells with interferon before injecting them into immunized F1 hybrid mice resulted in an enhanced allogeneic effect. These results are compatible with the hypothesis that interferon affects T cells and has an immunoregulatory role, either by inhibiting the action of suppressor cells or by promoting immunological maturation.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1102683
- author
- Strannegård, Örjan ; Larsson, Inger ; Lundgren, Erik ; Miörner, Håkan LU and Persson, H
- organization
- publishing date
- 1978
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Infection and Immunity
- volume
- 20
- issue
- 2
- pages
- 334 - 339
- publisher
- American Society for Microbiology
- external identifiers
-
- pmid:307536
- scopus:0017846731
- ISSN
- 1098-5522
- language
- English
- LU publication?
- yes
- id
- 767428df-8c24-4b4d-bca2-83be73e9b341 (old id 1102683)
- alternative location
- http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=421859&blobtype=pdf
- date added to LUP
- 2016-04-01 11:55:13
- date last changed
- 2021-01-03 10:34:03
@article{767428df-8c24-4b4d-bca2-83be73e9b341,
abstract = {{Interferon was found to have both suppressive and enhancing effects on the antibody response in newborn and adult mice. Evidence was obtained that these effects are primarily evoked during the initial steps controlling cell proliferation. Stimulation of thymus and spleen cells with a T-cell mitogen was enhanced by low doses and suppressed by high doses of interferon. Treatment of parental spleen cells with interferon before injecting them into immunized F1 hybrid mice resulted in an enhanced allogeneic effect. These results are compatible with the hypothesis that interferon affects T cells and has an immunoregulatory role, either by inhibiting the action of suppressor cells or by promoting immunological maturation.}},
author = {{Strannegård, Örjan and Larsson, Inger and Lundgren, Erik and Miörner, Håkan and Persson, H}},
issn = {{1098-5522}},
language = {{eng}},
number = {{2}},
pages = {{334--339}},
publisher = {{American Society for Microbiology}},
series = {{Infection and Immunity}},
title = {{Modulation of immune responses in newborn and adult mice by interferon}},
url = {{http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=421859&blobtype=pdf}},
volume = {{20}},
year = {{1978}},
}