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Modulation of immune responses in newborn and adult mice by interferon

Strannegård, Örjan; Larsson, Inger; Lundgren, Erik; Miörner, Håkan LU and Persson, H (1978) In Infection and Immunity 20(2). p.334-339
Abstract
Interferon was found to have both suppressive and enhancing effects on the antibody response in newborn and adult mice. Evidence was obtained that these effects are primarily evoked during the initial steps controlling cell proliferation. Stimulation of thymus and spleen cells with a T-cell mitogen was enhanced by low doses and suppressed by high doses of interferon. Treatment of parental spleen cells with interferon before injecting them into immunized F1 hybrid mice resulted in an enhanced allogeneic effect. These results are compatible with the hypothesis that interferon affects T cells and has an immunoregulatory role, either by inhibiting the action of suppressor cells or by promoting immunological maturation.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Infection and Immunity
volume
20
issue
2
pages
334 - 339
publisher
American Society for Microbiology
external identifiers
  • pmid:307536
  • scopus:0017846731
ISSN
1098-5522
language
English
LU publication?
yes
id
767428df-8c24-4b4d-bca2-83be73e9b341 (old id 1102683)
alternative location
http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=421859&blobtype=pdf
date added to LUP
2008-08-14 10:57:50
date last changed
2017-08-06 03:37:11
@article{767428df-8c24-4b4d-bca2-83be73e9b341,
  abstract     = {Interferon was found to have both suppressive and enhancing effects on the antibody response in newborn and adult mice. Evidence was obtained that these effects are primarily evoked during the initial steps controlling cell proliferation. Stimulation of thymus and spleen cells with a T-cell mitogen was enhanced by low doses and suppressed by high doses of interferon. Treatment of parental spleen cells with interferon before injecting them into immunized F1 hybrid mice resulted in an enhanced allogeneic effect. These results are compatible with the hypothesis that interferon affects T cells and has an immunoregulatory role, either by inhibiting the action of suppressor cells or by promoting immunological maturation.},
  author       = {Strannegård, Örjan and Larsson, Inger and Lundgren, Erik and Miörner, Håkan and Persson, H},
  issn         = {1098-5522},
  language     = {eng},
  number       = {2},
  pages        = {334--339},
  publisher    = {American Society for Microbiology},
  series       = {Infection and Immunity},
  title        = {Modulation of immune responses in newborn and adult mice by interferon},
  volume       = {20},
  year         = {1978},
}