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Regulation of mitogen-induced lymphocyte DNA synthesis by human interferon of different origins

Miörner, Håkan LU ; Landström, Lars-Erik; Larner, Ebba; Larsson, Inger; Lundgren, Erik and Strannegård, Örjan (1978) In Cellular Immunology 35(1). p.15-24
Abstract
Human fibroblast and leukocyte interferons were found to suppress lymphocyte mitogenesis induced by optimal doses of phytohemagglutinin and concanavalin A. In certain situations (low doses of mitogen and/or low doses of interferon), however, interferon significantly enhanced mitogenesis. In experiments using varying concentrations of interferon, dose-response curves with different slopes were obtained for fibroblast and leukocyte interferons. The effect of interferon was apparently exerted during early stages of the lymphocyte cell cycle. There was no inhibitory effect of interferon if the lymphocytes were washed with medium before being exposed to mitogen. Interferon increased the binding of radiolabeled mitogens to cells. The results... (More)
Human fibroblast and leukocyte interferons were found to suppress lymphocyte mitogenesis induced by optimal doses of phytohemagglutinin and concanavalin A. In certain situations (low doses of mitogen and/or low doses of interferon), however, interferon significantly enhanced mitogenesis. In experiments using varying concentrations of interferon, dose-response curves with different slopes were obtained for fibroblast and leukocyte interferons. The effect of interferon was apparently exerted during early stages of the lymphocyte cell cycle. There was no inhibitory effect of interferon if the lymphocytes were washed with medium before being exposed to mitogen. Interferon increased the binding of radiolabeled mitogens to cells. The results suggest that the immunological effects of interferon are consequences of actions on lymphoid cells. Fibroblast and leukocyte interferons seem to have different modes of action, or to bind differently to target cells. Possible mechanisms for the suppressive and enhancing effects of interferons on lymphoid cells are discussed. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cellular Immunology
volume
35
issue
1
pages
15 - 24
publisher
Elsevier
external identifiers
  • pmid:620425
  • scopus:0017887966
ISSN
0008-8749
DOI
10.1016/0008-8749(78)90122-3
language
English
LU publication?
yes
id
be3879ba-25c6-419d-b85d-ea306e3e222a (old id 1102688)
date added to LUP
2008-08-14 11:00:27
date last changed
2017-08-06 04:35:27
@article{be3879ba-25c6-419d-b85d-ea306e3e222a,
  abstract     = {Human fibroblast and leukocyte interferons were found to suppress lymphocyte mitogenesis induced by optimal doses of phytohemagglutinin and concanavalin A. In certain situations (low doses of mitogen and/or low doses of interferon), however, interferon significantly enhanced mitogenesis. In experiments using varying concentrations of interferon, dose-response curves with different slopes were obtained for fibroblast and leukocyte interferons. The effect of interferon was apparently exerted during early stages of the lymphocyte cell cycle. There was no inhibitory effect of interferon if the lymphocytes were washed with medium before being exposed to mitogen. Interferon increased the binding of radiolabeled mitogens to cells. The results suggest that the immunological effects of interferon are consequences of actions on lymphoid cells. Fibroblast and leukocyte interferons seem to have different modes of action, or to bind differently to target cells. Possible mechanisms for the suppressive and enhancing effects of interferons on lymphoid cells are discussed.},
  author       = {Miörner, Håkan and Landström, Lars-Erik and Larner, Ebba and Larsson, Inger and Lundgren, Erik and Strannegård, Örjan},
  issn         = {0008-8749},
  language     = {eng},
  number       = {1},
  pages        = {15--24},
  publisher    = {Elsevier},
  series       = {Cellular Immunology},
  title        = {Regulation of mitogen-induced lymphocyte DNA synthesis by human interferon of different origins},
  url          = {http://dx.doi.org/10.1016/0008-8749(78)90122-3},
  volume       = {35},
  year         = {1978},
}