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Effects of ethanol intake on lipoprotein lipase activity in adipose tissue of fasting subjects

Nilsson-Ehle, Peter LU ; Carlström, Sven and Belfrage, Per LU (1978) In Lipids 13(6). p.433-437
Abstract
Ethanol (ca. 1 g/kg body weight) was given alone or together with glucose or lipid (mixed triglycerides) perorally to young, fasting subjects. The changes with time (0-6 hr) of lipoprotein lipase activity (LLA) in adipose tissue, plasma glycerol, triglyceride, insulin, blood glucose, and alcohol concentrations were followed. A maximal mean blood alcohol concentration of 0.09% (w/v) was obtained 1 hr after ingestion with no apparent intoxicating effects. Ethanol intake prevented the previously observed [Nilsson-Ehle, P., S. Carlstrom, and P. Belfrage, Scand, J. Clin. Lab. Invest. 35:373 (1975)] glucose-induced rapid elevation of adipose tissue LLA but had small effects on this enzymatic activity when given alone or together with lipid.... (More)
Ethanol (ca. 1 g/kg body weight) was given alone or together with glucose or lipid (mixed triglycerides) perorally to young, fasting subjects. The changes with time (0-6 hr) of lipoprotein lipase activity (LLA) in adipose tissue, plasma glycerol, triglyceride, insulin, blood glucose, and alcohol concentrations were followed. A maximal mean blood alcohol concentration of 0.09% (w/v) was obtained 1 hr after ingestion with no apparent intoxicating effects. Ethanol intake prevented the previously observed [Nilsson-Ehle, P., S. Carlstrom, and P. Belfrage, Scand, J. Clin. Lab. Invest. 35:373 (1975)] glucose-induced rapid elevation of adipose tissue LLA but had small effects on this enzymatic activity when given alone or together with lipid. Confirming results by others, ethanol intake decreased plasma glycerol concentration and increased plasma triglycerides, especially after intake of lipid. It is suggested that ethanol intake interferes with the normal carbohydrate-induced elevation of adipose tissue LLA after a mixed meal, thereby decreasing the removal capacity for circulating dietary lipid and causing enhanced and prolonged alimentary hyperlipemia. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Lipids
volume
13
issue
6
pages
433 - 437
publisher
Springer
external identifiers
  • pmid:672483
  • scopus:0018185016
ISSN
0024-4201
DOI
10.1007/BF02533714
language
English
LU publication?
yes
id
041ce7f7-a1cc-4bf0-b9b6-22c613e7b56b (old id 1102705)
date added to LUP
2008-08-14 11:10:02
date last changed
2017-01-01 04:30:52
@article{041ce7f7-a1cc-4bf0-b9b6-22c613e7b56b,
  abstract     = {Ethanol (ca. 1 g/kg body weight) was given alone or together with glucose or lipid (mixed triglycerides) perorally to young, fasting subjects. The changes with time (0-6 hr) of lipoprotein lipase activity (LLA) in adipose tissue, plasma glycerol, triglyceride, insulin, blood glucose, and alcohol concentrations were followed. A maximal mean blood alcohol concentration of 0.09% (w/v) was obtained 1 hr after ingestion with no apparent intoxicating effects. Ethanol intake prevented the previously observed [Nilsson-Ehle, P., S. Carlstrom, and P. Belfrage, Scand, J. Clin. Lab. Invest. 35:373 (1975)] glucose-induced rapid elevation of adipose tissue LLA but had small effects on this enzymatic activity when given alone or together with lipid. Confirming results by others, ethanol intake decreased plasma glycerol concentration and increased plasma triglycerides, especially after intake of lipid. It is suggested that ethanol intake interferes with the normal carbohydrate-induced elevation of adipose tissue LLA after a mixed meal, thereby decreasing the removal capacity for circulating dietary lipid and causing enhanced and prolonged alimentary hyperlipemia.},
  author       = {Nilsson-Ehle, Peter and Carlström, Sven and Belfrage, Per},
  issn         = {0024-4201},
  language     = {eng},
  number       = {6},
  pages        = {433--437},
  publisher    = {Springer},
  series       = {Lipids},
  title        = {Effects of ethanol intake on lipoprotein lipase activity in adipose tissue of fasting subjects},
  url          = {http://dx.doi.org/10.1007/BF02533714},
  volume       = {13},
  year         = {1978},
}