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Effects of leukocyte and fibroblast interferon on events in the fibroblast cell cycle

Lundgren, E; Larsson, I; Miörner, Håkan LU and Strannegard, O (1979) In Journal of General Virology 42(3). p.589-595
Abstract
Serum-depleted human foetal skin fibroblasts were stimulated by addition of 10% foetal calf serum to proliferate synchronously for at least one cell cycle. This proliferation was suppressed by leukocyte or fibroblast interferon (IF), which prolonged the G1 phase and diminished the rate of DNA synthesis during the S phase in a dose-dependent manner. When used in identical concentration, as judged in terms of units of antiviral activity, fibroblast IF had more pronounced effects on cell cycle events than leukocyte IF. Interferon exerted its effect in early G1, before the cells were irreversibly committed to DNA synthesis.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of General Virology
volume
42
issue
3
pages
589 - 595
publisher
Society for General Microbiology
external identifiers
  • pmid:430031
  • scopus:0018372169
ISSN
1465-2099
DOI
10.1099/0022-1317-42-3-589
language
English
LU publication?
yes
id
3ef692b3-0a1b-40e7-9262-bb6de8c80b97 (old id 1102730)
date added to LUP
2008-08-14 09:47:59
date last changed
2017-02-26 04:13:36
@article{3ef692b3-0a1b-40e7-9262-bb6de8c80b97,
  abstract     = {Serum-depleted human foetal skin fibroblasts were stimulated by addition of 10% foetal calf serum to proliferate synchronously for at least one cell cycle. This proliferation was suppressed by leukocyte or fibroblast interferon (IF), which prolonged the G1 phase and diminished the rate of DNA synthesis during the S phase in a dose-dependent manner. When used in identical concentration, as judged in terms of units of antiviral activity, fibroblast IF had more pronounced effects on cell cycle events than leukocyte IF. Interferon exerted its effect in early G1, before the cells were irreversibly committed to DNA synthesis.},
  author       = {Lundgren, E and Larsson, I and Miörner, Håkan and Strannegard, O},
  issn         = {1465-2099},
  language     = {eng},
  number       = {3},
  pages        = {589--595},
  publisher    = {Society for General Microbiology},
  series       = {Journal of General Virology},
  title        = {Effects of leukocyte and fibroblast interferon on events in the fibroblast cell cycle},
  url          = {http://dx.doi.org/10.1099/0022-1317-42-3-589},
  volume       = {42},
  year         = {1979},
}