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Chronopharmacologic aspects of hexobarbital oxidation rate in rats

Püschel, Klaus; Mätzsch, Thomas LU and von Mayersbach, Heinz (1981) In Archives of Toxicology 48(2-3). p.199-204
Abstract
Circadian variations of hexobarbital oxidation rate in rat liver and the relationship to serum corticosterone levels were determined in 324 animals subjected to different lighting regimen and feeding schedules.--Rats maintained under standard light/dark conditions and with free access to food showed a significant circadian hexobarbital oxidase rhythmicity. Inversion of the light/dark cycle and time feeding was followed by significant changes of the 24-h means of hexobarbital oxidation rate as well as of the shape and phasing of the circadian pattern. The animals' response to the experimentally altered environmental conditions did not reveal a predictable relationship between the shape and phasing of the rhythmic patterns of liver... (More)
Circadian variations of hexobarbital oxidation rate in rat liver and the relationship to serum corticosterone levels were determined in 324 animals subjected to different lighting regimen and feeding schedules.--Rats maintained under standard light/dark conditions and with free access to food showed a significant circadian hexobarbital oxidase rhythmicity. Inversion of the light/dark cycle and time feeding was followed by significant changes of the 24-h means of hexobarbital oxidation rate as well as of the shape and phasing of the circadian pattern. The animals' response to the experimentally altered environmental conditions did not reveal a predictable relationship between the shape and phasing of the rhythmic patterns of liver hexobarbital oxidase activity and of corticosterone levels in blood serum; the rats subjected to timed feeding showed decreased levels of corticosterone whereas the hexobarbital oxidation rate of the liver was increased. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Hexobarbital oxidation, Corticosterone, Circadianrhythm, Rat liver
in
Archives of Toxicology
volume
48
issue
2-3
pages
199 - 204
publisher
Springer
external identifiers
  • pmid:7027999
  • scopus:0019454254
ISSN
0340-5761
DOI
10.1007/BF00310488
language
English
LU publication?
no
id
9dcaffd6-40d1-4a0c-a1e3-3f83c933c23a (old id 1102868)
date added to LUP
2008-08-13 16:03:12
date last changed
2017-01-01 06:41:40
@article{9dcaffd6-40d1-4a0c-a1e3-3f83c933c23a,
  abstract     = {Circadian variations of hexobarbital oxidation rate in rat liver and the relationship to serum corticosterone levels were determined in 324 animals subjected to different lighting regimen and feeding schedules.--Rats maintained under standard light/dark conditions and with free access to food showed a significant circadian hexobarbital oxidase rhythmicity. Inversion of the light/dark cycle and time feeding was followed by significant changes of the 24-h means of hexobarbital oxidation rate as well as of the shape and phasing of the circadian pattern. The animals' response to the experimentally altered environmental conditions did not reveal a predictable relationship between the shape and phasing of the rhythmic patterns of liver hexobarbital oxidase activity and of corticosterone levels in blood serum; the rats subjected to timed feeding showed decreased levels of corticosterone whereas the hexobarbital oxidation rate of the liver was increased.},
  author       = {Püschel, Klaus and Mätzsch, Thomas and von Mayersbach, Heinz},
  issn         = {0340-5761},
  keyword      = {Hexobarbital oxidation,Corticosterone,Circadianrhythm,Rat liver},
  language     = {eng},
  number       = {2-3},
  pages        = {199--204},
  publisher    = {Springer},
  series       = {Archives of Toxicology},
  title        = {Chronopharmacologic aspects of hexobarbital oxidation rate in rats},
  url          = {http://dx.doi.org/10.1007/BF00310488},
  volume       = {48},
  year         = {1981},
}