Chronopharmacologic aspects of hexobarbital oxidation rate in rats
(1981) In Archives of Toxicology 48(2-3). p.199-204- Abstract
- Circadian variations of hexobarbital oxidation rate in rat liver and the relationship to serum corticosterone levels were determined in 324 animals subjected to different lighting regimen and feeding schedules.--Rats maintained under standard light/dark conditions and with free access to food showed a significant circadian hexobarbital oxidase rhythmicity. Inversion of the light/dark cycle and time feeding was followed by significant changes of the 24-h means of hexobarbital oxidation rate as well as of the shape and phasing of the circadian pattern. The animals' response to the experimentally altered environmental conditions did not reveal a predictable relationship between the shape and phasing of the rhythmic patterns of liver... (More)
- Circadian variations of hexobarbital oxidation rate in rat liver and the relationship to serum corticosterone levels were determined in 324 animals subjected to different lighting regimen and feeding schedules.--Rats maintained under standard light/dark conditions and with free access to food showed a significant circadian hexobarbital oxidase rhythmicity. Inversion of the light/dark cycle and time feeding was followed by significant changes of the 24-h means of hexobarbital oxidation rate as well as of the shape and phasing of the circadian pattern. The animals' response to the experimentally altered environmental conditions did not reveal a predictable relationship between the shape and phasing of the rhythmic patterns of liver hexobarbital oxidase activity and of corticosterone levels in blood serum; the rats subjected to timed feeding showed decreased levels of corticosterone whereas the hexobarbital oxidation rate of the liver was increased. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1102868
- author
- Püschel, Klaus ; Mätzsch, Thomas LU and von Mayersbach, Heinz
- publishing date
- 1981
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Hexobarbital oxidation, Corticosterone, Circadianrhythm, Rat liver
- in
- Archives of Toxicology
- volume
- 48
- issue
- 2-3
- pages
- 199 - 204
- publisher
- Springer
- external identifiers
-
- pmid:7027999
- scopus:0019454254
- ISSN
- 0340-5761
- DOI
- 10.1007/BF00310488
- language
- English
- LU publication?
- no
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)
- id
- 9dcaffd6-40d1-4a0c-a1e3-3f83c933c23a (old id 1102868)
- date added to LUP
- 2016-04-01 15:32:20
- date last changed
- 2021-01-03 03:15:49
@article{9dcaffd6-40d1-4a0c-a1e3-3f83c933c23a,
abstract = {{Circadian variations of hexobarbital oxidation rate in rat liver and the relationship to serum corticosterone levels were determined in 324 animals subjected to different lighting regimen and feeding schedules.--Rats maintained under standard light/dark conditions and with free access to food showed a significant circadian hexobarbital oxidase rhythmicity. Inversion of the light/dark cycle and time feeding was followed by significant changes of the 24-h means of hexobarbital oxidation rate as well as of the shape and phasing of the circadian pattern. The animals' response to the experimentally altered environmental conditions did not reveal a predictable relationship between the shape and phasing of the rhythmic patterns of liver hexobarbital oxidase activity and of corticosterone levels in blood serum; the rats subjected to timed feeding showed decreased levels of corticosterone whereas the hexobarbital oxidation rate of the liver was increased.}},
author = {{Püschel, Klaus and Mätzsch, Thomas and von Mayersbach, Heinz}},
issn = {{0340-5761}},
keywords = {{Hexobarbital oxidation; Corticosterone; Circadianrhythm; Rat liver}},
language = {{eng}},
number = {{2-3}},
pages = {{199--204}},
publisher = {{Springer}},
series = {{Archives of Toxicology}},
title = {{Chronopharmacologic aspects of hexobarbital oxidation rate in rats}},
url = {{http://dx.doi.org/10.1007/BF00310488}},
doi = {{10.1007/BF00310488}},
volume = {{48}},
year = {{1981}},
}