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Effects of weight reduction on plasma lipoproteins and adipose tissue metabolism in obese subjects

Sorbris, Ralph; Petersson, Bengt-Göran and Nilsson-Ehle, Peter LU (1981) In European Journal of Clinical Investigation 11(6). p.491-500
Abstract
The relationship between obesity and alterations in adipose tissue metabolism and lipid transport was studied in fourteen obese subjects before and after a weight reduction of 4-22 kg. Blood glucose and plasma insulin patterns after peroral glucose intake improved significantly, and plasma glucagon levels decreased markedly after treatment. Plasma triglyceride and total cholesterol levels were not altered, but there was a 20% (P less than 0.05) increase in HDL concentrations. Plasma free fatty acid and glycerol concentrations decreased, in parallel to a decrease in lipolysis rate in vitro. Lipoprotein lipase and hepatic lipase activities in postheparin plasma, as well as the intravenous fat tolerance test, were normal and did not change... (More)
The relationship between obesity and alterations in adipose tissue metabolism and lipid transport was studied in fourteen obese subjects before and after a weight reduction of 4-22 kg. Blood glucose and plasma insulin patterns after peroral glucose intake improved significantly, and plasma glucagon levels decreased markedly after treatment. Plasma triglyceride and total cholesterol levels were not altered, but there was a 20% (P less than 0.05) increase in HDL concentrations. Plasma free fatty acid and glycerol concentrations decreased, in parallel to a decrease in lipolysis rate in vitro. Lipoprotein lipase and hepatic lipase activities in postheparin plasma, as well as the intravenous fat tolerance test, were normal and did not change significantly after weight loss. Lipoprotein lipase activity in adipose tissue, expressed per cell, was elevated and did not change after weight reduction. Also, the enzyme activity did not increase after glucose intake before or after treatment. The lack of effect on lipoprotein lipase activity and regulation in combination with significant improvements of other aspects of lipid and glucose transport is consistent with the view that alterations in LPL activity and regulation may represent an early and possibly primary defect in the development of obesity. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Plasma lipoproteins, high density lipoprotein, apo AI, adipose tissue, lipolysis, lipoprotein lipase, insulin, glucagon
in
European Journal of Clinical Investigation
volume
11
issue
6
pages
491 - 500
publisher
Wiley-Blackwell
external identifiers
  • pmid:6800825
  • scopus:0019849192
ISSN
0014-2972
DOI
10.1111/j.1365-2362.1981.tb02019.x
language
English
LU publication?
yes
id
a098a23b-5703-44cf-ac7b-a9941bbfadd1 (old id 1102891)
date added to LUP
2008-08-13 16:23:33
date last changed
2017-08-20 03:40:06
@article{a098a23b-5703-44cf-ac7b-a9941bbfadd1,
  abstract     = {The relationship between obesity and alterations in adipose tissue metabolism and lipid transport was studied in fourteen obese subjects before and after a weight reduction of 4-22 kg. Blood glucose and plasma insulin patterns after peroral glucose intake improved significantly, and plasma glucagon levels decreased markedly after treatment. Plasma triglyceride and total cholesterol levels were not altered, but there was a 20% (P less than 0.05) increase in HDL concentrations. Plasma free fatty acid and glycerol concentrations decreased, in parallel to a decrease in lipolysis rate in vitro. Lipoprotein lipase and hepatic lipase activities in postheparin plasma, as well as the intravenous fat tolerance test, were normal and did not change significantly after weight loss. Lipoprotein lipase activity in adipose tissue, expressed per cell, was elevated and did not change after weight reduction. Also, the enzyme activity did not increase after glucose intake before or after treatment. The lack of effect on lipoprotein lipase activity and regulation in combination with significant improvements of other aspects of lipid and glucose transport is consistent with the view that alterations in LPL activity and regulation may represent an early and possibly primary defect in the development of obesity.},
  author       = {Sorbris, Ralph and Petersson, Bengt-Göran and Nilsson-Ehle, Peter},
  issn         = {0014-2972},
  keyword      = {Plasma lipoproteins,high density lipoprotein,apo AI,adipose tissue,lipolysis,lipoprotein lipase,insulin,glucagon},
  language     = {eng},
  number       = {6},
  pages        = {491--500},
  publisher    = {Wiley-Blackwell},
  series       = {European Journal of Clinical Investigation},
  title        = {Effects of weight reduction on plasma lipoproteins and adipose tissue metabolism in obese subjects},
  url          = {http://dx.doi.org/10.1111/j.1365-2362.1981.tb02019.x},
  volume       = {11},
  year         = {1981},
}