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Increased occurrence of hepatitis A with cyclic outbreaks among drug addicts in a Swedish community

Widell, Anders LU ; Hansson, Bengt-Göran LU ; Moestrup, T and Nordenfelt, E (1983) In Infection 11(4). p.198-200
Abstract
To determine the prevalence of antibodies to Hepatitis A virus (anti-HAV) among drug addicts, sera collected in a Swedish city during a ten-year period from 234 drug addicts with acute hepatitis B were tested for anti-HAV. The results were compared with the normal population, where only 3.8% of those born after 1950 were anti-HAV-positive. In individuals born between 1941 and 1965, 8.2% in the normal population and 30.2% of the drug addicts were anti-HAV-positive (p less than 0.001). The level of immunity to hepatitis A among drug addicts ranged from 7.7% to 60% during the ten-year period. Low levels of immunity were seen in the years preceeding outbreaks of hepatitis A among drug addicts. These outbreaks occurred in a cyclic pattern.... (More)
To determine the prevalence of antibodies to Hepatitis A virus (anti-HAV) among drug addicts, sera collected in a Swedish city during a ten-year period from 234 drug addicts with acute hepatitis B were tested for anti-HAV. The results were compared with the normal population, where only 3.8% of those born after 1950 were anti-HAV-positive. In individuals born between 1941 and 1965, 8.2% in the normal population and 30.2% of the drug addicts were anti-HAV-positive (p less than 0.001). The level of immunity to hepatitis A among drug addicts ranged from 7.7% to 60% during the ten-year period. Low levels of immunity were seen in the years preceeding outbreaks of hepatitis A among drug addicts. These outbreaks occurred in a cyclic pattern. Higher levels of immunity were seen after each outbreak. (Less)
Abstract (Swedish)
Abstract in German

Zur Bestimmung der Prävalenz vonHepatitis A Virus-Antikörpern (anti-HAV) bei Drogenabhängigen wurden Seren von 234 Drogenabhängigen mit akuter Hepatitis B, die in einer schwedischen Stadt während zehn Jahren gesammelt worden waren, auf anti-HAV getestet. Zum Vergleich wurde eine normale Bevölkerungsgruppe herangezogen, bei der nur 3,8% der nach 1950 Geborenen und 8,2% der Jahrgänge 1941–1965 anti-HAV positiv waren. Hingegen war bei 30,2% der Drogenabhängigen anti-HAV nachzuweisen (p<0,001). Die Rate von Drogenabhängigen mit Immunschutz variierte innerhalb von zehn Jahren zwischen 7,7% und 60%. In den Jahren von Hepatitis A-Ausbrüchen waren die Immunitätsraten jeweils niedrig. Die Ausbrüche traten... (More)
Abstract in German

Zur Bestimmung der Prävalenz vonHepatitis A Virus-Antikörpern (anti-HAV) bei Drogenabhängigen wurden Seren von 234 Drogenabhängigen mit akuter Hepatitis B, die in einer schwedischen Stadt während zehn Jahren gesammelt worden waren, auf anti-HAV getestet. Zum Vergleich wurde eine normale Bevölkerungsgruppe herangezogen, bei der nur 3,8% der nach 1950 Geborenen und 8,2% der Jahrgänge 1941–1965 anti-HAV positiv waren. Hingegen war bei 30,2% der Drogenabhängigen anti-HAV nachzuweisen (p<0,001). Die Rate von Drogenabhängigen mit Immunschutz variierte innerhalb von zehn Jahren zwischen 7,7% und 60%. In den Jahren von Hepatitis A-Ausbrüchen waren die Immunitätsraten jeweils niedrig. Die Ausbrüche traten zyklisch auf. Nach jedem Ausbruch war jeweils eine höhere Rate von Drogensüchtigen mit Immunschutz festzustellen. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Infection
volume
11
issue
4
pages
198 - 200
publisher
Springer
external identifiers
  • pmid:6618674
  • scopus:0020636103
ISSN
1439-0973
DOI
10.1007/BF01641196
language
English
LU publication?
yes
id
eebf9bd2-bf5d-4e6a-aeb0-a489e8de6835 (old id 1102993)
date added to LUP
2016-04-01 16:23:51
date last changed
2021-01-03 09:50:27
@article{eebf9bd2-bf5d-4e6a-aeb0-a489e8de6835,
  abstract     = {{To determine the prevalence of antibodies to Hepatitis A virus (anti-HAV) among drug addicts, sera collected in a Swedish city during a ten-year period from 234 drug addicts with acute hepatitis B were tested for anti-HAV. The results were compared with the normal population, where only 3.8% of those born after 1950 were anti-HAV-positive. In individuals born between 1941 and 1965, 8.2% in the normal population and 30.2% of the drug addicts were anti-HAV-positive (p less than 0.001). The level of immunity to hepatitis A among drug addicts ranged from 7.7% to 60% during the ten-year period. Low levels of immunity were seen in the years preceeding outbreaks of hepatitis A among drug addicts. These outbreaks occurred in a cyclic pattern. Higher levels of immunity were seen after each outbreak.}},
  author       = {{Widell, Anders and Hansson, Bengt-Göran and Moestrup, T and Nordenfelt, E}},
  issn         = {{1439-0973}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{198--200}},
  publisher    = {{Springer}},
  series       = {{Infection}},
  title        = {{Increased occurrence of hepatitis A with cyclic outbreaks among drug addicts in a Swedish community}},
  url          = {{http://dx.doi.org/10.1007/BF01641196}},
  doi          = {{10.1007/BF01641196}},
  volume       = {{11}},
  year         = {{1983}},
}