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Increased occurrence of hepatitis A with cyclic outbreaks among drug addicts in a Swedish community

Widell, Anders LU ; Hansson, Bengt-Göran LU ; Moestrup, T and Nordenfelt, E (1983) In Infection 11(4). p.198-200
Abstract (Swedish)
Abstract in German

Zur Bestimmung der Prävalenz vonHepatitis A Virus-Antikörpern (anti-HAV) bei Drogenabhängigen wurden Seren von 234 Drogenabhängigen mit akuter Hepatitis B, die in einer schwedischen Stadt während zehn Jahren gesammelt worden waren, auf anti-HAV getestet. Zum Vergleich wurde eine normale Bevölkerungsgruppe herangezogen, bei der nur 3,8% der nach 1950 Geborenen und 8,2% der Jahrgänge 1941–1965 anti-HAV positiv waren. Hingegen war bei 30,2% der Drogenabhängigen anti-HAV nachzuweisen (p<0,001). Die Rate von Drogenabhängigen mit Immunschutz variierte innerhalb von zehn Jahren zwischen 7,7% und 60%. In den Jahren von Hepatitis A-Ausbrüchen waren die Immunitätsraten jeweils niedrig. Die Ausbrüche traten... (More)
Abstract in German

Zur Bestimmung der Prävalenz vonHepatitis A Virus-Antikörpern (anti-HAV) bei Drogenabhängigen wurden Seren von 234 Drogenabhängigen mit akuter Hepatitis B, die in einer schwedischen Stadt während zehn Jahren gesammelt worden waren, auf anti-HAV getestet. Zum Vergleich wurde eine normale Bevölkerungsgruppe herangezogen, bei der nur 3,8% der nach 1950 Geborenen und 8,2% der Jahrgänge 1941–1965 anti-HAV positiv waren. Hingegen war bei 30,2% der Drogenabhängigen anti-HAV nachzuweisen (p<0,001). Die Rate von Drogenabhängigen mit Immunschutz variierte innerhalb von zehn Jahren zwischen 7,7% und 60%. In den Jahren von Hepatitis A-Ausbrüchen waren die Immunitätsraten jeweils niedrig. Die Ausbrüche traten zyklisch auf. Nach jedem Ausbruch war jeweils eine höhere Rate von Drogensüchtigen mit Immunschutz festzustellen. (Less)
Abstract
To determine the prevalence of antibodies to Hepatitis A virus (anti-HAV) among drug addicts, sera collected in a Swedish city during a ten-year period from 234 drug addicts with acute hepatitis B were tested for anti-HAV. The results were compared with the normal population, where only 3.8% of those born after 1950 were anti-HAV-positive. In individuals born between 1941 and 1965, 8.2% in the normal population and 30.2% of the drug addicts were anti-HAV-positive (p less than 0.001). The level of immunity to hepatitis A among drug addicts ranged from 7.7% to 60% during the ten-year period. Low levels of immunity were seen in the years preceeding outbreaks of hepatitis A among drug addicts. These outbreaks occurred in a cyclic pattern.... (More)
To determine the prevalence of antibodies to Hepatitis A virus (anti-HAV) among drug addicts, sera collected in a Swedish city during a ten-year period from 234 drug addicts with acute hepatitis B were tested for anti-HAV. The results were compared with the normal population, where only 3.8% of those born after 1950 were anti-HAV-positive. In individuals born between 1941 and 1965, 8.2% in the normal population and 30.2% of the drug addicts were anti-HAV-positive (p less than 0.001). The level of immunity to hepatitis A among drug addicts ranged from 7.7% to 60% during the ten-year period. Low levels of immunity were seen in the years preceeding outbreaks of hepatitis A among drug addicts. These outbreaks occurred in a cyclic pattern. Higher levels of immunity were seen after each outbreak. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Infection
volume
11
issue
4
pages
198 - 200
publisher
Urban & Vogel
external identifiers
  • pmid:6618674
  • scopus:0020636103
ISSN
1439-0973
DOI
10.1007/BF01641196
language
English
LU publication?
yes
id
eebf9bd2-bf5d-4e6a-aeb0-a489e8de6835 (old id 1102993)
date added to LUP
2008-08-13 11:05:27
date last changed
2017-05-07 04:17:42
@article{eebf9bd2-bf5d-4e6a-aeb0-a489e8de6835,
  abstract     = {To determine the prevalence of antibodies to Hepatitis A virus (anti-HAV) among drug addicts, sera collected in a Swedish city during a ten-year period from 234 drug addicts with acute hepatitis B were tested for anti-HAV. The results were compared with the normal population, where only 3.8% of those born after 1950 were anti-HAV-positive. In individuals born between 1941 and 1965, 8.2% in the normal population and 30.2% of the drug addicts were anti-HAV-positive (p less than 0.001). The level of immunity to hepatitis A among drug addicts ranged from 7.7% to 60% during the ten-year period. Low levels of immunity were seen in the years preceeding outbreaks of hepatitis A among drug addicts. These outbreaks occurred in a cyclic pattern. Higher levels of immunity were seen after each outbreak.},
  author       = {Widell, Anders and Hansson, Bengt-Göran and Moestrup, T and Nordenfelt, E},
  issn         = {1439-0973},
  language     = {eng},
  number       = {4},
  pages        = {198--200},
  publisher    = {Urban & Vogel},
  series       = {Infection},
  title        = {Increased occurrence of hepatitis A with cyclic outbreaks among drug addicts in a Swedish community},
  url          = {http://dx.doi.org/10.1007/BF01641196},
  volume       = {11},
  year         = {1983},
}