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Clinical aspects of delta infection

Moestrup, T; Hansson, Bengt-Göran LU ; Widell, Anders LU and Nordenfelt, E (1983) In British medical journal (Clinical research ed.) 286(6359). p.87-90
Abstract
The clinical features of delta infection were analysed retrospectively in 191 hepatitis B surface antigen (HBsAg) carriers and 592 cases of acute hepatitis B seen over 11 years in the Swedish town of Malmo (population 250 000). With a few exceptions delta infections occurred exclusively in drug addicts. In the chronic HBsAg-carriers the most common clinical manifestation was an episode of acute hepatitis, which in some individuals became severe with a pronounced rise in serum alanine aminotransferase activity for many months. During the period of delta infection the HBsAg titre was lowered and in three out of 26 cases the patient lost HBsAg altogether and developed hepatitis B surface antibodies (anti-HBs). In one patient the acute... (More)
The clinical features of delta infection were analysed retrospectively in 191 hepatitis B surface antigen (HBsAg) carriers and 592 cases of acute hepatitis B seen over 11 years in the Swedish town of Malmo (population 250 000). With a few exceptions delta infections occurred exclusively in drug addicts. In the chronic HBsAg-carriers the most common clinical manifestation was an episode of acute hepatitis, which in some individuals became severe with a pronounced rise in serum alanine aminotransferase activity for many months. During the period of delta infection the HBsAg titre was lowered and in three out of 26 cases the patient lost HBsAg altogether and developed hepatitis B surface antibodies (anti-HBs). In one patient the acute hepatitis due to delta infection was fulminant and fatal. In patients with acute hepatitis B the clinical picture did not distinguish between those with and without simultaneous delta infection. The frequency with which acute hepatitis B was succeeded by a chronic carrier state was the same whether or not the patient was infected simultaneously with the delta agent. The discovery of the delta agent has improved understanding of the natural history of chronic hepatitis B infection in drug addicts. Thus, instances of acute hepatitis in a chronic carrier, previously termed hepatitis non-A, non-B, may actually be episodes of delta infection. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British medical journal (Clinical research ed.)
volume
286
issue
6359
pages
87 - 90
publisher
BMJ Publishing Group
external identifiers
  • pmid:6401506
  • scopus:0020700558
ISSN
0267-0623
language
English
LU publication?
yes
id
c4225cf7-9174-449a-a984-e78581e2b5cb (old id 1102997)
alternative location
http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1546393&blobtype=pdf
date added to LUP
2008-08-13 11:07:35
date last changed
2017-08-06 04:38:55
@article{c4225cf7-9174-449a-a984-e78581e2b5cb,
  abstract     = {The clinical features of delta infection were analysed retrospectively in 191 hepatitis B surface antigen (HBsAg) carriers and 592 cases of acute hepatitis B seen over 11 years in the Swedish town of Malmo (population 250 000). With a few exceptions delta infections occurred exclusively in drug addicts. In the chronic HBsAg-carriers the most common clinical manifestation was an episode of acute hepatitis, which in some individuals became severe with a pronounced rise in serum alanine aminotransferase activity for many months. During the period of delta infection the HBsAg titre was lowered and in three out of 26 cases the patient lost HBsAg altogether and developed hepatitis B surface antibodies (anti-HBs). In one patient the acute hepatitis due to delta infection was fulminant and fatal. In patients with acute hepatitis B the clinical picture did not distinguish between those with and without simultaneous delta infection. The frequency with which acute hepatitis B was succeeded by a chronic carrier state was the same whether or not the patient was infected simultaneously with the delta agent. The discovery of the delta agent has improved understanding of the natural history of chronic hepatitis B infection in drug addicts. Thus, instances of acute hepatitis in a chronic carrier, previously termed hepatitis non-A, non-B, may actually be episodes of delta infection.},
  author       = {Moestrup, T and Hansson, Bengt-Göran and Widell, Anders and Nordenfelt, E},
  issn         = {0267-0623},
  language     = {eng},
  number       = {6359},
  pages        = {87--90},
  publisher    = {BMJ Publishing Group},
  series       = {British medical journal (Clinical research ed.)},
  title        = {Clinical aspects of delta infection},
  volume       = {286},
  year         = {1983},
}