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The Opportunity of Proteomics to Advance the Understanding of Intra- and Extracellular Regulation of Malignant Hematopoiesis

Jassinskaja, Maria LU and Hansson, Jenny LU orcid (2022) In Frontiers in Cell and Developmental Biology 10.
Abstract

Fetal and adult hematopoiesis are regulated by largely distinct sets of cell-intrinsic gene regulatory networks as well as extracellular cues in their respective microenvironment. These ontogeny-specific programs drive hematopoietic stem and progenitor cells (HSPCs) in fetus and adult to divergent susceptibility to initiation and progression of hematological malignancies, such as leukemia. Elucidating how leukemogenic hits disturb the intra- and extracellular programs in HSPCs along ontogeny will provide a better understanding of the causes for age-associated differences in malignant hematopoiesis and facilitate the improvement of strategies for prevention and treatment of pediatric and adult acute leukemia. Here, we review current... (More)

Fetal and adult hematopoiesis are regulated by largely distinct sets of cell-intrinsic gene regulatory networks as well as extracellular cues in their respective microenvironment. These ontogeny-specific programs drive hematopoietic stem and progenitor cells (HSPCs) in fetus and adult to divergent susceptibility to initiation and progression of hematological malignancies, such as leukemia. Elucidating how leukemogenic hits disturb the intra- and extracellular programs in HSPCs along ontogeny will provide a better understanding of the causes for age-associated differences in malignant hematopoiesis and facilitate the improvement of strategies for prevention and treatment of pediatric and adult acute leukemia. Here, we review current knowledge of the intrinsic and extrinsic programs regulating normal and malignant hematopoiesis, with a particular focus on the differences between infant and adult acute leukemia. We discuss the recent advances in mass spectrometry-based proteomics and its opportunity for resolving the interplay of cell-intrinsic and niche-associated factors in regulating malignant hematopoiesis.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
developmental hematopoiesis, hematopoiesis, leukemia, post-transcriptional regulation, proteomics
in
Frontiers in Cell and Developmental Biology
volume
10
article number
824098
publisher
Frontiers Media S. A.
external identifiers
  • pmid:35350382
  • scopus:85127235206
ISSN
2296-634X
DOI
10.3389/fcell.2022.824098
language
English
LU publication?
yes
id
1102d5f9-4fb2-4135-a8fd-8168ec479c37
date added to LUP
2022-05-04 12:08:03
date last changed
2025-02-07 13:06:09
@article{1102d5f9-4fb2-4135-a8fd-8168ec479c37,
  abstract     = {{<p>Fetal and adult hematopoiesis are regulated by largely distinct sets of cell-intrinsic gene regulatory networks as well as extracellular cues in their respective microenvironment. These ontogeny-specific programs drive hematopoietic stem and progenitor cells (HSPCs) in fetus and adult to divergent susceptibility to initiation and progression of hematological malignancies, such as leukemia. Elucidating how leukemogenic hits disturb the intra- and extracellular programs in HSPCs along ontogeny will provide a better understanding of the causes for age-associated differences in malignant hematopoiesis and facilitate the improvement of strategies for prevention and treatment of pediatric and adult acute leukemia. Here, we review current knowledge of the intrinsic and extrinsic programs regulating normal and malignant hematopoiesis, with a particular focus on the differences between infant and adult acute leukemia. We discuss the recent advances in mass spectrometry-based proteomics and its opportunity for resolving the interplay of cell-intrinsic and niche-associated factors in regulating malignant hematopoiesis.</p>}},
  author       = {{Jassinskaja, Maria and Hansson, Jenny}},
  issn         = {{2296-634X}},
  keywords     = {{developmental hematopoiesis; hematopoiesis; leukemia; post-transcriptional regulation; proteomics}},
  language     = {{eng}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Cell and Developmental Biology}},
  title        = {{The Opportunity of Proteomics to Advance the Understanding of Intra- and Extracellular Regulation of Malignant Hematopoiesis}},
  url          = {{http://dx.doi.org/10.3389/fcell.2022.824098}},
  doi          = {{10.3389/fcell.2022.824098}},
  volume       = {{10}},
  year         = {{2022}},
}