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The influence of total hepatectomy on cerebral energy state, ammonia-related amino acids of the brain and plasma amino acids in the rat

Holmin, T; Agardh, Carl-David LU ; Alinder, G; Herlin, P and Hultberg, B (1983) In European Journal of Clinical Investigation 13(3). p.215-220
Abstract
The influence of total hepatectomy on cerebral energy state, ammonia-related amino acids of the brain tissue and plasma amino acids was studied in anaesthetized rats after total hepatectomy. The hepatectomy was performed with the aid of a microsurgical three-stage procedure. In the first stage, division of the inferior vena cava was performed. In the second stage 4 weeks later a porta-caval anastomosis was constructed, followed after 1 week by a total hepatectomy. The brain energy state, defined as the concentrations of phosphocreatine, ATP, ADP and AMP, was unchanged 4 h after the hepatectomy. Plasma amino acids did not differ significantly between hepatectomized and shunted control rats. On the other hand, clear-cut increases in the... (More)
The influence of total hepatectomy on cerebral energy state, ammonia-related amino acids of the brain tissue and plasma amino acids was studied in anaesthetized rats after total hepatectomy. The hepatectomy was performed with the aid of a microsurgical three-stage procedure. In the first stage, division of the inferior vena cava was performed. In the second stage 4 weeks later a porta-caval anastomosis was constructed, followed after 1 week by a total hepatectomy. The brain energy state, defined as the concentrations of phosphocreatine, ATP, ADP and AMP, was unchanged 4 h after the hepatectomy. Plasma amino acids did not differ significantly between hepatectomized and shunted control rats. On the other hand, clear-cut increases in the concentrations of glutamine, and decreases in the concentrations of glutamate and aspartate, were observed in the fronto-parietal part of the cerebral cortex and the brain stem. These changes might explain the minor manifestations of cerebral dysfunction in the early phase of the hepatectomized state. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
labile phosphates, Hepatectom, amino acids, microsurgery, rat
in
European Journal of Clinical Investigation
volume
13
issue
3
pages
215 - 220
publisher
Wiley-Blackwell
external identifiers
  • pmid:6135613
  • scopus:0020615354
ISSN
0014-2972
DOI
10.1111/j.1365-2362.1983.tb00090.x
language
English
LU publication?
yes
id
e669f067-e851-434d-9ca5-59b5f41368d6 (old id 1103058)
date added to LUP
2008-08-13 09:13:30
date last changed
2017-01-01 04:58:35
@article{e669f067-e851-434d-9ca5-59b5f41368d6,
  abstract     = {The influence of total hepatectomy on cerebral energy state, ammonia-related amino acids of the brain tissue and plasma amino acids was studied in anaesthetized rats after total hepatectomy. The hepatectomy was performed with the aid of a microsurgical three-stage procedure. In the first stage, division of the inferior vena cava was performed. In the second stage 4 weeks later a porta-caval anastomosis was constructed, followed after 1 week by a total hepatectomy. The brain energy state, defined as the concentrations of phosphocreatine, ATP, ADP and AMP, was unchanged 4 h after the hepatectomy. Plasma amino acids did not differ significantly between hepatectomized and shunted control rats. On the other hand, clear-cut increases in the concentrations of glutamine, and decreases in the concentrations of glutamate and aspartate, were observed in the fronto-parietal part of the cerebral cortex and the brain stem. These changes might explain the minor manifestations of cerebral dysfunction in the early phase of the hepatectomized state.},
  author       = {Holmin, T and Agardh, Carl-David and Alinder, G and Herlin, P and Hultberg, B},
  issn         = {0014-2972},
  keyword      = {labile phosphates,Hepatectom,amino acids,microsurgery,rat},
  language     = {eng},
  number       = {3},
  pages        = {215--220},
  publisher    = {Wiley-Blackwell},
  series       = {European Journal of Clinical Investigation},
  title        = {The influence of total hepatectomy on cerebral energy state, ammonia-related amino acids of the brain and plasma amino acids in the rat},
  url          = {http://dx.doi.org/10.1111/j.1365-2362.1983.tb00090.x},
  volume       = {13},
  year         = {1983},
}