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Plasma high density lipoproteins and lipolytic enzyme activities in diabetic patients

Agardh, Carl-David LU ; Sartor, G and Nilsson-Ehle, Peter LU (1983) In Acta Medica Scandinavica 213(2). p.123-128
Abstract
Eighty diabetic patients, consecutively selected from an out-patient clinic, were studied with regard to plasma lipoprotein levels, especially HDL. Patients treated with sulphonylureas had 24% lower HDL cholesterol concentrations (p less than 0.01) but only about 7% lower apo AI levels (n.s.) than those on insulin treatment. This difference could at least partly be explained by differences in age and type of diabetes. There was no relationship between the degree of diabetic control, as measured by fasting blood glucose levels, and HDL levels. In two subgroups of insulin-treated diabetics, selected to represent extremely low and high HDL levels (range 0.5-0.8 and 1.8-2.0 mmol/l, respectively) but matched with regard to age, duration of... (More)
Eighty diabetic patients, consecutively selected from an out-patient clinic, were studied with regard to plasma lipoprotein levels, especially HDL. Patients treated with sulphonylureas had 24% lower HDL cholesterol concentrations (p less than 0.01) but only about 7% lower apo AI levels (n.s.) than those on insulin treatment. This difference could at least partly be explained by differences in age and type of diabetes. There was no relationship between the degree of diabetic control, as measured by fasting blood glucose levels, and HDL levels. In two subgroups of insulin-treated diabetics, selected to represent extremely low and high HDL levels (range 0.5-0.8 and 1.8-2.0 mmol/l, respectively) but matched with regard to age, duration of diabetes, insulin dosage and diabetic control, the activities of lipoprotein lipase and hepatic lipase in postheparin plasma were also recorded. The high HDL group had significantly higher lipoprotein lipase activities (p less than 0.01) and significantly lower hepatic lipase activities (p less than 0.05) than the low HDL group, supporting the hypothetical roles of these enzymes in HDL metabolism, and offering a tentative mechanism behind the large variability of HDL levels in diabetics. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Medica Scandinavica
volume
213
issue
2
pages
123 - 128
publisher
Norstedts
external identifiers
  • pmid:6340423
  • scopus:0020662569
ISSN
0001-6101
language
English
LU publication?
yes
id
35634ebc-3c61-4be1-a89e-7092bb65f81d (old id 1103131)
date added to LUP
2008-08-13 08:35:55
date last changed
2017-01-01 07:23:41
@article{35634ebc-3c61-4be1-a89e-7092bb65f81d,
  abstract     = {Eighty diabetic patients, consecutively selected from an out-patient clinic, were studied with regard to plasma lipoprotein levels, especially HDL. Patients treated with sulphonylureas had 24% lower HDL cholesterol concentrations (p less than 0.01) but only about 7% lower apo AI levels (n.s.) than those on insulin treatment. This difference could at least partly be explained by differences in age and type of diabetes. There was no relationship between the degree of diabetic control, as measured by fasting blood glucose levels, and HDL levels. In two subgroups of insulin-treated diabetics, selected to represent extremely low and high HDL levels (range 0.5-0.8 and 1.8-2.0 mmol/l, respectively) but matched with regard to age, duration of diabetes, insulin dosage and diabetic control, the activities of lipoprotein lipase and hepatic lipase in postheparin plasma were also recorded. The high HDL group had significantly higher lipoprotein lipase activities (p less than 0.01) and significantly lower hepatic lipase activities (p less than 0.05) than the low HDL group, supporting the hypothetical roles of these enzymes in HDL metabolism, and offering a tentative mechanism behind the large variability of HDL levels in diabetics.},
  author       = {Agardh, Carl-David and Sartor, G and Nilsson-Ehle, Peter},
  issn         = {0001-6101},
  language     = {eng},
  number       = {2},
  pages        = {123--128},
  publisher    = {Norstedts},
  series       = {Acta Medica Scandinavica},
  title        = {Plasma high density lipoproteins and lipolytic enzyme activities in diabetic patients},
  volume       = {213},
  year         = {1983},
}