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Development of supersensitivity to methacholine in the rat detrusor following either parasympathetic denervation or decentralization

Ekström, J and Malmberg, Lars LU (1984) In Acta Physiologica Scandinavica 122(2). p.175-179
Abstract
The male rat urinary bladder belongs to those few structures where both the post- and preganglionic parasympathetic nerves are accessible for severance. In the present study the sensitivity to the parasympathomimetic drug methacholine of muscle strips of either denervated or decentralized bladders was examined in vitro. One week postoperatively denervated and decentralized bladders were sensitized to the same degree, the ED50 values being 4 times less than ED50 of unoperated control bladders. In contrast to the decentralized bladders the supersensitivity in the denervated ones was found to have increased further when tested four weeks postoperatively, the ED50 value being about 20 times less than that of controls. The present findings are... (More)
The male rat urinary bladder belongs to those few structures where both the post- and preganglionic parasympathetic nerves are accessible for severance. In the present study the sensitivity to the parasympathomimetic drug methacholine of muscle strips of either denervated or decentralized bladders was examined in vitro. One week postoperatively denervated and decentralized bladders were sensitized to the same degree, the ED50 values being 4 times less than ED50 of unoperated control bladders. In contrast to the decentralized bladders the supersensitivity in the denervated ones was found to have increased further when tested four weeks postoperatively, the ED50 value being about 20 times less than that of controls. The present findings are in agreement with Cannon's "law of denervation". The results are discussed in relation to possible mechanisms behind the phenomenon of supersensitivity. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Physiologica Scandinavica
volume
122
issue
2
pages
175 - 179
publisher
Wiley-Blackwell
external identifiers
  • pmid:6393713
  • scopus:0021719451
ISSN
0001-6772
language
English
LU publication?
yes
id
8284c84c-4db2-483c-8db7-d3955f9a6934 (old id 1103265)
date added to LUP
2008-08-12 15:14:00
date last changed
2017-09-03 04:44:20
@article{8284c84c-4db2-483c-8db7-d3955f9a6934,
  abstract     = {The male rat urinary bladder belongs to those few structures where both the post- and preganglionic parasympathetic nerves are accessible for severance. In the present study the sensitivity to the parasympathomimetic drug methacholine of muscle strips of either denervated or decentralized bladders was examined in vitro. One week postoperatively denervated and decentralized bladders were sensitized to the same degree, the ED50 values being 4 times less than ED50 of unoperated control bladders. In contrast to the decentralized bladders the supersensitivity in the denervated ones was found to have increased further when tested four weeks postoperatively, the ED50 value being about 20 times less than that of controls. The present findings are in agreement with Cannon's "law of denervation". The results are discussed in relation to possible mechanisms behind the phenomenon of supersensitivity.},
  author       = {Ekström, J and Malmberg, Lars},
  issn         = {0001-6772},
  language     = {eng},
  number       = {2},
  pages        = {175--179},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Physiologica Scandinavica},
  title        = {Development of supersensitivity to methacholine in the rat detrusor following either parasympathetic denervation or decentralization},
  volume       = {122},
  year         = {1984},
}