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Hepatitis B virus-DNA in the serum of patients followed-up longitudinally with acute and chronic hepatitis B

Moestrup, T; Hansson, B G; Widell, Anders LU ; Blomberg, J and Nordenfelt, E (1985) In Journal of Medical Virology 17(4). p.337-344
Abstract
Sera from 79 patients with acute self-limiting hepatitis, 17 patients with acute hepatitis B evolving into chronic HBsAg carriership, and 43 chronic HBsAg carriers without a history of acute hepatitis were analyzed for presence of hepatitis B virus (HBV)-DNA by a molecular hybridization technique. In acute self-limiting hepatitis, HBV-DNA was cleared within a few weeks after the onset of clinical symptoms. The longest period of DNA positivity observed in this group was 42 days. In 29 of 52 patients HBV-DNA was cleared before HBeAg disappeared. Among 17 patients who became chronic HBsAg carriers, HBV-DNA was present for more than 6 months in all but one. Most of the HBsAg carriers eventually cleared HBV-DNA. The DNA clearance frequently... (More)
Sera from 79 patients with acute self-limiting hepatitis, 17 patients with acute hepatitis B evolving into chronic HBsAg carriership, and 43 chronic HBsAg carriers without a history of acute hepatitis were analyzed for presence of hepatitis B virus (HBV)-DNA by a molecular hybridization technique. In acute self-limiting hepatitis, HBV-DNA was cleared within a few weeks after the onset of clinical symptoms. The longest period of DNA positivity observed in this group was 42 days. In 29 of 52 patients HBV-DNA was cleared before HBeAg disappeared. Among 17 patients who became chronic HBsAg carriers, HBV-DNA was present for more than 6 months in all but one. Most of the HBsAg carriers eventually cleared HBV-DNA. The DNA clearance frequently preceeded the conversion of HBeAg to anti-HBe. Thus, in many patients there was a transitional period with HBeAg but without HBV-DNA. HBV-DNA was found to be a better index of impending chronicity than HBeAg since persistence of HBeAg for more than 42 days was noted in 10% of the patients who nevertheless cleared HBsAg within 6 months. By that time all those patients had turned negative for HBV-DNA. On the other hand, in 16 of the 17 patients who became chronic carriers of HBsAg, HBV-DNA as well as HBeAg persisted for more than 6 months. The present results also suggest that infectivity in acute hepatitis B is a feature mainly of the presymptomatic and early symptomatic period. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
hepatitis, viral DNA, molecular hybridization, HBeAg
in
Journal of Medical Virology
volume
17
issue
4
pages
337 - 344
publisher
John Wiley & Sons
external identifiers
  • pmid:4078560
  • scopus:0022340983
ISSN
1096-9071
DOI
10.1002/jmv.1890170406
language
English
LU publication?
yes
id
e135c7dd-8271-4c8d-b49d-0fb29a85a078 (old id 1103352)
date added to LUP
2008-08-11 12:35:05
date last changed
2017-08-06 03:46:33
@article{e135c7dd-8271-4c8d-b49d-0fb29a85a078,
  abstract     = {Sera from 79 patients with acute self-limiting hepatitis, 17 patients with acute hepatitis B evolving into chronic HBsAg carriership, and 43 chronic HBsAg carriers without a history of acute hepatitis were analyzed for presence of hepatitis B virus (HBV)-DNA by a molecular hybridization technique. In acute self-limiting hepatitis, HBV-DNA was cleared within a few weeks after the onset of clinical symptoms. The longest period of DNA positivity observed in this group was 42 days. In 29 of 52 patients HBV-DNA was cleared before HBeAg disappeared. Among 17 patients who became chronic HBsAg carriers, HBV-DNA was present for more than 6 months in all but one. Most of the HBsAg carriers eventually cleared HBV-DNA. The DNA clearance frequently preceeded the conversion of HBeAg to anti-HBe. Thus, in many patients there was a transitional period with HBeAg but without HBV-DNA. HBV-DNA was found to be a better index of impending chronicity than HBeAg since persistence of HBeAg for more than 42 days was noted in 10% of the patients who nevertheless cleared HBsAg within 6 months. By that time all those patients had turned negative for HBV-DNA. On the other hand, in 16 of the 17 patients who became chronic carriers of HBsAg, HBV-DNA as well as HBeAg persisted for more than 6 months. The present results also suggest that infectivity in acute hepatitis B is a feature mainly of the presymptomatic and early symptomatic period.},
  author       = {Moestrup, T and Hansson, B G and Widell, Anders and Blomberg, J and Nordenfelt, E},
  issn         = {1096-9071},
  keyword      = {hepatitis,viral DNA,molecular hybridization,HBeAg},
  language     = {eng},
  number       = {4},
  pages        = {337--344},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Medical Virology},
  title        = {Hepatitis B virus-DNA in the serum of patients followed-up longitudinally with acute and chronic hepatitis B},
  url          = {http://dx.doi.org/10.1002/jmv.1890170406},
  volume       = {17},
  year         = {1985},
}