Advanced

Supersensitivity to methacholine in rat urethra following hypertrophy or disuse

Ekström, J and Malmberg, Lars LU (1985) In Acta Pharmacologica et Toxicologica 57(4). p.297-300
Abstract
It has been possible to sensitize the rat urethra without cutting its nerves. This was achieved by hypertrophy or disuse. Hypertrophy of the urethra (2-4-fold weight increase) was caused by the presence of an intraluminal paraffin bolus. Disuse was caused by diverting the flow of urine from the lower urinary tract. When examined in vitro after an experimental period of 1 to 4 weeks the EC50 value of the parasympathomimetic drug methacholine was in both cases half of that of controls. The common cause of the development of supersensitivity in the two types of experiments is thought to be decreases in the local concentration of transmitter at the muscle cells. The present findings favour the idea of a parasympathetic motor control of the rat... (More)
It has been possible to sensitize the rat urethra without cutting its nerves. This was achieved by hypertrophy or disuse. Hypertrophy of the urethra (2-4-fold weight increase) was caused by the presence of an intraluminal paraffin bolus. Disuse was caused by diverting the flow of urine from the lower urinary tract. When examined in vitro after an experimental period of 1 to 4 weeks the EC50 value of the parasympathomimetic drug methacholine was in both cases half of that of controls. The common cause of the development of supersensitivity in the two types of experiments is thought to be decreases in the local concentration of transmitter at the muscle cells. The present findings favour the idea of a parasympathetic motor control of the rat urethra. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Pharmacologica et Toxicologica
volume
57
issue
4
pages
297 - 300
publisher
Nordic Pharmacological Society
external identifiers
  • pmid:3909740
  • scopus:0022381158
ISSN
0001-6683
language
English
LU publication?
yes
id
4082ea31-b856-4c0f-90d7-bb3e9c8535d5 (old id 1103420)
date added to LUP
2008-08-11 13:39:26
date last changed
2017-02-22 11:44:33
@article{4082ea31-b856-4c0f-90d7-bb3e9c8535d5,
  abstract     = {It has been possible to sensitize the rat urethra without cutting its nerves. This was achieved by hypertrophy or disuse. Hypertrophy of the urethra (2-4-fold weight increase) was caused by the presence of an intraluminal paraffin bolus. Disuse was caused by diverting the flow of urine from the lower urinary tract. When examined in vitro after an experimental period of 1 to 4 weeks the EC50 value of the parasympathomimetic drug methacholine was in both cases half of that of controls. The common cause of the development of supersensitivity in the two types of experiments is thought to be decreases in the local concentration of transmitter at the muscle cells. The present findings favour the idea of a parasympathetic motor control of the rat urethra.},
  author       = {Ekström, J and Malmberg, Lars},
  issn         = {0001-6683},
  language     = {eng},
  number       = {4},
  pages        = {297--300},
  publisher    = {Nordic Pharmacological Society},
  series       = {Acta Pharmacologica et Toxicologica},
  title        = {Supersensitivity to methacholine in rat urethra following hypertrophy or disuse},
  volume       = {57},
  year         = {1985},
}