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Role of vasoactive intestinal polypeptide (VIP) in the neurogenic vasodilatation of the portal vein in the rabbit

Hellstrand, Per LU ; Fahrenkrug, J; Uddman, Rolf LU and Järhult, Johannes (1985) In Regulatory Peptides 12(4). p.309-316
Abstract
A coarse network of nerve fibres displaying immunoreactivity for vasoactive intestinal polypeptide (VIP) was found in the wall of the hepatic portal vein of the rabbit. Electrical field stimulation of the rabbit portal vein in vitro, in the presence of adrenergic and cholinergic blockade, caused a marked relaxation of the vessel and a release of VIP into the perfusate. Addition of VIP to the tissue bath elicited a concentration-dependent inhibition of the mechanical activity of the portal vein. The results suggest that VIP containing neurones might participate in the non-cholinergic, non-adrenergic vasodilatation of the portal vein in the rabbit.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
neurogenic vasodilatation, portal vein, vasoactive intestinal polypeptide, rabbit
in
Regulatory Peptides
volume
12
issue
4
pages
309 - 316
publisher
Elsevier
external identifiers
  • pmid:3911302
  • scopus:0022359579
ISSN
1873-1686
DOI
10.1016/0167-0115(85)90174-0
language
English
LU publication?
yes
id
a51f9e4d-fb9d-4fff-9963-d1aed467e47c (old id 1103432)
date added to LUP
2008-08-11 13:51:37
date last changed
2017-08-06 03:45:58
@article{a51f9e4d-fb9d-4fff-9963-d1aed467e47c,
  abstract     = {A coarse network of nerve fibres displaying immunoreactivity for vasoactive intestinal polypeptide (VIP) was found in the wall of the hepatic portal vein of the rabbit. Electrical field stimulation of the rabbit portal vein in vitro, in the presence of adrenergic and cholinergic blockade, caused a marked relaxation of the vessel and a release of VIP into the perfusate. Addition of VIP to the tissue bath elicited a concentration-dependent inhibition of the mechanical activity of the portal vein. The results suggest that VIP containing neurones might participate in the non-cholinergic, non-adrenergic vasodilatation of the portal vein in the rabbit.},
  author       = {Hellstrand, Per and Fahrenkrug, J and Uddman, Rolf and Järhult, Johannes},
  issn         = {1873-1686},
  keyword      = {neurogenic vasodilatation,portal vein,vasoactive intestinal polypeptide,rabbit},
  language     = {eng},
  number       = {4},
  pages        = {309--316},
  publisher    = {Elsevier},
  series       = {Regulatory Peptides},
  title        = {Role of vasoactive intestinal polypeptide (VIP) in the neurogenic vasodilatation of the portal vein in the rabbit},
  url          = {http://dx.doi.org/10.1016/0167-0115(85)90174-0},
  volume       = {12},
  year         = {1985},
}