Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Transfer of IgA deficiency to a bone-marrow-grafted patient with aplastic anaemia

Hammarström, Lennart ; Lönnqvist, Berit ; Ringden, Olle ; Smith, C I Edvard and Wiebe, Thomas LU (1985) In The Lancet 325(8432). p.778-781
Abstract
IgA deficiency developed in a 2-year-old boy with aplastic anaemia who received a bone-marrow graft from his HLA-identical, 6-year-old, IgA-deficient sister. Southern blot analysis revealed the presence of alpha-genes in both children, thus suggesting a defect of lymphocyte stem-cell differentiation as a cause of IgA deficiency. Tissue typing showed homozygosity of HLA A1, B8, DR3, the haplotype associated with IgA deficiency in healthy people. Despite normal serum levels of IgG subclasses in both donor and recipient, both children showed a relative lack of specific IgG2 anticarbohydrate antibodies. This suggests that their IgA deficiency is part of a more fundamental aberration of immunoglobulin class and subclass distribution.
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Lancet
volume
325
issue
8432
pages
778 - 781
publisher
Elsevier
external identifiers
  • pmid:2858666
  • scopus:0021963399
ISSN
1474-547X
DOI
10.1016/S0140-6736(85)91446-1
language
English
LU publication?
yes
id
9b135665-3b5c-4129-b783-e2b56925f981 (old id 1103440)
date added to LUP
2016-04-01 12:05:14
date last changed
2021-08-15 03:57:34
@article{9b135665-3b5c-4129-b783-e2b56925f981,
  abstract     = {{IgA deficiency developed in a 2-year-old boy with aplastic anaemia who received a bone-marrow graft from his HLA-identical, 6-year-old, IgA-deficient sister. Southern blot analysis revealed the presence of alpha-genes in both children, thus suggesting a defect of lymphocyte stem-cell differentiation as a cause of IgA deficiency. Tissue typing showed homozygosity of HLA A1, B8, DR3, the haplotype associated with IgA deficiency in healthy people. Despite normal serum levels of IgG subclasses in both donor and recipient, both children showed a relative lack of specific IgG2 anticarbohydrate antibodies. This suggests that their IgA deficiency is part of a more fundamental aberration of immunoglobulin class and subclass distribution.}},
  author       = {{Hammarström, Lennart and Lönnqvist, Berit and Ringden, Olle and Smith, C I Edvard and Wiebe, Thomas}},
  issn         = {{1474-547X}},
  language     = {{eng}},
  number       = {{8432}},
  pages        = {{778--781}},
  publisher    = {{Elsevier}},
  series       = {{The Lancet}},
  title        = {{Transfer of IgA deficiency to a bone-marrow-grafted patient with aplastic anaemia}},
  url          = {{http://dx.doi.org/10.1016/S0140-6736(85)91446-1}},
  doi          = {{10.1016/S0140-6736(85)91446-1}},
  volume       = {{325}},
  year         = {{1985}},
}