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Platelet and adipocyte thermogenesis in hypothyroid patients: a microcalorimetric study

Valdemarsson, S; Fagher, B; Hedner, P; Monti, M and Nilsson-Ehle, Peter LU (1985) In Acta Endocrinologica 108(3). p.361-366
Abstract
Direct microcalorimetry was used for measurements of heat production in cell suspensions of platelets and adipocytes, obtained from hypothyroid patients before and after 3 months on full L-thyroxine substitution. Platelet heat production was significantly lower than normal before treatment and increased in all 10 patients studied; the mean value increased from 51.3 +/- 1.6 fW/cell before to 57.1 +/- 1.8 fW/cell after therapy (P less than 0.001). Similarily, adipocyte heat production was initially significantly lower than normal and increased during treatment in all 6 patients investigated. The mean value for heat production per adipocyte was 18.8 +/- 1.7 pW/cell before and 32.4 +/- 2.5 pW/cell after therapy (P less than 0.025), which is... (More)
Direct microcalorimetry was used for measurements of heat production in cell suspensions of platelets and adipocytes, obtained from hypothyroid patients before and after 3 months on full L-thyroxine substitution. Platelet heat production was significantly lower than normal before treatment and increased in all 10 patients studied; the mean value increased from 51.3 +/- 1.6 fW/cell before to 57.1 +/- 1.8 fW/cell after therapy (P less than 0.001). Similarily, adipocyte heat production was initially significantly lower than normal and increased during treatment in all 6 patients investigated. The mean value for heat production per adipocyte was 18.8 +/- 1.7 pW/cell before and 32.4 +/- 2.5 pW/cell after therapy (P less than 0.025), which is still below the level recorded in lean healthy subjects. The adipocyte size did not change significantly. The increase in adipocyte heat production was correlated to the increase in S-triiodothyronine levels (r = 0.84, P less than 0.05). In hypothyroidism, the total metabolic activity seems to be comparatively more reduced in adipocytes than in platelets. A difference may exist between these cells with regard to recovery of normal metabolic activity during treatment for hypothyroidism. Direct microcalorimetry appears to be an adequate method for monitoring net metabolic effects of thyroid hormones in these cells. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Endocrinologica
volume
108
issue
3
pages
361 - 366
publisher
Scandinavian University Press
external identifiers
  • pmid:3984664
  • scopus:0021928515
ISSN
0001-5598
language
English
LU publication?
yes
id
ea889a37-f116-412a-b118-1b38d92beb74 (old id 1103474)
date added to LUP
2008-08-11 14:27:24
date last changed
2017-01-01 07:25:06
@article{ea889a37-f116-412a-b118-1b38d92beb74,
  abstract     = {Direct microcalorimetry was used for measurements of heat production in cell suspensions of platelets and adipocytes, obtained from hypothyroid patients before and after 3 months on full L-thyroxine substitution. Platelet heat production was significantly lower than normal before treatment and increased in all 10 patients studied; the mean value increased from 51.3 +/- 1.6 fW/cell before to 57.1 +/- 1.8 fW/cell after therapy (P less than 0.001). Similarily, adipocyte heat production was initially significantly lower than normal and increased during treatment in all 6 patients investigated. The mean value for heat production per adipocyte was 18.8 +/- 1.7 pW/cell before and 32.4 +/- 2.5 pW/cell after therapy (P less than 0.025), which is still below the level recorded in lean healthy subjects. The adipocyte size did not change significantly. The increase in adipocyte heat production was correlated to the increase in S-triiodothyronine levels (r = 0.84, P less than 0.05). In hypothyroidism, the total metabolic activity seems to be comparatively more reduced in adipocytes than in platelets. A difference may exist between these cells with regard to recovery of normal metabolic activity during treatment for hypothyroidism. Direct microcalorimetry appears to be an adequate method for monitoring net metabolic effects of thyroid hormones in these cells.},
  author       = {Valdemarsson, S and Fagher, B and Hedner, P and Monti, M and Nilsson-Ehle, Peter},
  issn         = {0001-5598},
  language     = {eng},
  number       = {3},
  pages        = {361--366},
  publisher    = {Scandinavian University Press},
  series       = {Acta Endocrinologica},
  title        = {Platelet and adipocyte thermogenesis in hypothyroid patients: a microcalorimetric study},
  volume       = {108},
  year         = {1985},
}