Advanced

Long term follow up of chronic hepatitis B virus infection in intravenous drug abusers and homosexual men

Moestrup, T; Hansson, Bengt-Göran LU ; Widell, Anders LU ; Nordenfelt, Erik and Hägerstrand, Inga (1986) In B M J: British Medical Journal1995-01-01+01:00 292(6524). p.854-857
Abstract
Long term follow up of 16 homosexual men and 78 intravenous drug abusers who were chronic carriers of hepatitis B surface antigen (HBsAg) showed fundamental differences between the two groups. Viral replication, expressed by the presence of hepatitis B e antigen, lasted for four years or more in 10 out of 14 (71%) of the homosexual men whereas it was not present in 43 out of 73 (59%) of the drug addicts within one year. This shows a difference in the immunological response between homosexual HBsAg carriers and addicts that is not related to infection with human T cell lymphotropic virus type III. Severe histological damage such as chronic aggressive hepatitis, cirrhosis, or primary liver cancer was found in more than half of the homosexual... (More)
Long term follow up of 16 homosexual men and 78 intravenous drug abusers who were chronic carriers of hepatitis B surface antigen (HBsAg) showed fundamental differences between the two groups. Viral replication, expressed by the presence of hepatitis B e antigen, lasted for four years or more in 10 out of 14 (71%) of the homosexual men whereas it was not present in 43 out of 73 (59%) of the drug addicts within one year. This shows a difference in the immunological response between homosexual HBsAg carriers and addicts that is not related to infection with human T cell lymphotropic virus type III. Severe histological damage such as chronic aggressive hepatitis, cirrhosis, or primary liver cancer was found in more than half of the homosexual men who underwent biopsy examinations. In drug addicts chronic persistent hepatitis was a regular finding in the absence of markers of delta infection, but in those addicts infected with the delta agent the degree of liver damage was comparable with that found in homosexual men. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
B M J: British Medical Journal1995-01-01+01:00
volume
292
issue
6524
pages
854 - 857
publisher
BMJ Publishing Group
external identifiers
  • pmid:3083909
  • scopus:0022598471
ISSN
1756-1833
language
English
LU publication?
yes
id
de66a93b-1594-4340-b9c4-beaf1b1f71f6 (old id 1103492)
alternative location
http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1339968&blobtype=pdf
date added to LUP
2008-08-11 08:20:20
date last changed
2017-01-01 06:50:24
@article{de66a93b-1594-4340-b9c4-beaf1b1f71f6,
  abstract     = {Long term follow up of 16 homosexual men and 78 intravenous drug abusers who were chronic carriers of hepatitis B surface antigen (HBsAg) showed fundamental differences between the two groups. Viral replication, expressed by the presence of hepatitis B e antigen, lasted for four years or more in 10 out of 14 (71%) of the homosexual men whereas it was not present in 43 out of 73 (59%) of the drug addicts within one year. This shows a difference in the immunological response between homosexual HBsAg carriers and addicts that is not related to infection with human T cell lymphotropic virus type III. Severe histological damage such as chronic aggressive hepatitis, cirrhosis, or primary liver cancer was found in more than half of the homosexual men who underwent biopsy examinations. In drug addicts chronic persistent hepatitis was a regular finding in the absence of markers of delta infection, but in those addicts infected with the delta agent the degree of liver damage was comparable with that found in homosexual men.},
  author       = {Moestrup, T and Hansson, Bengt-Göran and Widell, Anders and Nordenfelt, Erik and Hägerstrand, Inga},
  issn         = {1756-1833},
  language     = {eng},
  number       = {6524},
  pages        = {854--857},
  publisher    = {BMJ Publishing Group},
  series       = {B M J: British Medical Journal1995-01-01+01:00},
  title        = {Long term follow up of chronic hepatitis B virus infection in intravenous drug abusers and homosexual men},
  volume       = {292},
  year         = {1986},
}