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Imbalanced serum IgG subclass pattern in toxic shock syndrome patients: deficiency of specific IgG1 and IgG4 subclass antibodies to toxic shock syndrome toxin 1

Christensson, B; Johansson, Hugo LU and Oxelius, Vivi-Anne LU (1986) In Clinical and Experimental Immunology 66(2). p.443-449
Abstract
An imbalanced serum IgG subclass pattern was identified in 10 patients with toxic shock syndrome (TSS) showing remarkably low subclass levels of various combinations. IgG2 levels were significantly reduced as compared to normal controls. The IgG subclass-specificity of antibodies to toxic shock syndrome toxin (TSST-1) was investigated by a solid-phase radioimmunoassay. TSS-patients lacked pre-immunity to TSST-1 in all four IgG subclasses. Normally acquired immunity to the toxin as well as the serological response developing in two patients with TSS was generally restricted to IgG1 and IgG4. A strong booster response of all four IgG subclasses was seen in three patients with S. aureus septicaemia due to TSST-1 producing strains. The lack of... (More)
An imbalanced serum IgG subclass pattern was identified in 10 patients with toxic shock syndrome (TSS) showing remarkably low subclass levels of various combinations. IgG2 levels were significantly reduced as compared to normal controls. The IgG subclass-specificity of antibodies to toxic shock syndrome toxin (TSST-1) was investigated by a solid-phase radioimmunoassay. TSS-patients lacked pre-immunity to TSST-1 in all four IgG subclasses. Normally acquired immunity to the toxin as well as the serological response developing in two patients with TSS was generally restricted to IgG1 and IgG4. A strong booster response of all four IgG subclasses was seen in three patients with S. aureus septicaemia due to TSST-1 producing strains. The lack of specific IgG1 and IgG4 antibodies to TSST-1 and the low serum IgG subclass levels found in the TSS-patients could be of pathogenetic significance and help to explain the susceptibility to TSS in certain individuals. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
IgG subclass toxic shock syndrome TSST-1
in
Clinical and Experimental Immunology
volume
66
issue
2
pages
443 - 449
publisher
British Society for Immunology
external identifiers
  • pmid:3815898
  • scopus:0023019827
ISSN
0009-9104
language
English
LU publication?
yes
id
1621a34f-40bd-4077-848e-92827e3c9d32 (old id 1103533)
alternative location
http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1542541&blobtype=pdf
date added to LUP
2008-08-11 09:01:30
date last changed
2017-01-01 05:19:00
@article{1621a34f-40bd-4077-848e-92827e3c9d32,
  abstract     = {An imbalanced serum IgG subclass pattern was identified in 10 patients with toxic shock syndrome (TSS) showing remarkably low subclass levels of various combinations. IgG2 levels were significantly reduced as compared to normal controls. The IgG subclass-specificity of antibodies to toxic shock syndrome toxin (TSST-1) was investigated by a solid-phase radioimmunoassay. TSS-patients lacked pre-immunity to TSST-1 in all four IgG subclasses. Normally acquired immunity to the toxin as well as the serological response developing in two patients with TSS was generally restricted to IgG1 and IgG4. A strong booster response of all four IgG subclasses was seen in three patients with S. aureus septicaemia due to TSST-1 producing strains. The lack of specific IgG1 and IgG4 antibodies to TSST-1 and the low serum IgG subclass levels found in the TSS-patients could be of pathogenetic significance and help to explain the susceptibility to TSS in certain individuals.},
  author       = {Christensson, B and Johansson, Hugo and Oxelius, Vivi-Anne},
  issn         = {0009-9104},
  keyword      = {IgG subclass toxic shock syndrome TSST-1},
  language     = {eng},
  number       = {2},
  pages        = {443--449},
  publisher    = {British Society for Immunology},
  series       = {Clinical and Experimental Immunology},
  title        = {Imbalanced serum IgG subclass pattern in toxic shock syndrome patients: deficiency of specific IgG1 and IgG4 subclass antibodies to toxic shock syndrome toxin 1},
  volume       = {66},
  year         = {1986},
}