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Comparative immunohistochemical demonstration of difucosylated carbohydrate antigens and CEA in adenomas and carcinomas of the rectum and rectosigmoid

Enblad, P ; Glimelius, B ; Busch, C ; Påhlman, L ; Ponten, J ; Chester, Alan LU and Lundblad, A (1986) In Anticancer research 6(2). p.139-146
Abstract
The present immunohistochemical investigation reveals that difucosylated carbohydrate antigens (DFCA) are extensively expressed in rectal and rectosigmoid carcinomas while normal mucosa and hyperplastic polyps are mainly negative. The adenomas showed intermediate staining patterns where adenomas with villous structures and moderate-severe dysplasia resembled of carcinomas. CEA was more extensively expressed in both normal, premalignant, and malignant tissue. Thus, DFCA is better than CEA as a discriminator between normal and malignant tissue in the distal large bowel, and may be used in future studies with the intention of advancing our understanding of the neoplastic process and assessing clinical relevance.
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Anticancer research
volume
6
issue
2
pages
139 - 146
publisher
International Institute of Cancer Research
external identifiers
  • pmid:3707049
  • scopus:0022686515
ISSN
1791-7530
language
English
LU publication?
yes
id
1fcab181-9fde-4d89-9376-44f821dac294 (old id 1103568)
date added to LUP
2016-04-01 12:37:35
date last changed
2024-01-09 03:09:25
@article{1fcab181-9fde-4d89-9376-44f821dac294,
  abstract     = {{The present immunohistochemical investigation reveals that difucosylated carbohydrate antigens (DFCA) are extensively expressed in rectal and rectosigmoid carcinomas while normal mucosa and hyperplastic polyps are mainly negative. The adenomas showed intermediate staining patterns where adenomas with villous structures and moderate-severe dysplasia resembled of carcinomas. CEA was more extensively expressed in both normal, premalignant, and malignant tissue. Thus, DFCA is better than CEA as a discriminator between normal and malignant tissue in the distal large bowel, and may be used in future studies with the intention of advancing our understanding of the neoplastic process and assessing clinical relevance.}},
  author       = {{Enblad, P and Glimelius, B and Busch, C and Påhlman, L and Ponten, J and Chester, Alan and Lundblad, A}},
  issn         = {{1791-7530}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{139--146}},
  publisher    = {{International Institute of Cancer Research}},
  series       = {{Anticancer research}},
  title        = {{Comparative immunohistochemical demonstration of difucosylated carbohydrate antigens and CEA in adenomas and carcinomas of the rectum and rectosigmoid}},
  volume       = {{6}},
  year         = {{1986}},
}