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Heparin-induced osteoporosis in rats

Mätzsch, Thomas LU ; Bergqvist, D; Hedner, Ulla LU ; Nilsson, B and Ostergaard, P (1986) In Thrombosis and Haemostasis 56(3). p.293-294
Abstract
In order to study the effect of heparin in inducing osteoporosis, 30 female rats were divided in two groups and treated with daily injections of 2 IU heparin/g body weight for 33 and 65 days and compared with the same number of rats acting as controls. The mineral bone mass in the femora of the animals was measured quantitatively. A significant (p less than 0.001) reduction in bone mineral mass was found in the heparin-treated animals. This effect was present to the same degree after 33 days as after 65 days of treatment. It is concluded that heparin in this dose causes osteoporosis in rats after 33 days and that the described method can be used as an experimental model for further studies on this topic.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Thrombosis and Haemostasis
volume
56
issue
3
pages
293 - 294
publisher
F K Schattauer Verlag Gmbh
external identifiers
  • pmid:3563963
  • scopus:0022965241
ISSN
0340-6245
language
English
LU publication?
yes
id
64f3348e-b9ac-4def-a79a-dbb527b2cdf4 (old id 1103597)
date added to LUP
2008-08-11 09:40:19
date last changed
2017-08-13 04:30:34
@article{64f3348e-b9ac-4def-a79a-dbb527b2cdf4,
  abstract     = {In order to study the effect of heparin in inducing osteoporosis, 30 female rats were divided in two groups and treated with daily injections of 2 IU heparin/g body weight for 33 and 65 days and compared with the same number of rats acting as controls. The mineral bone mass in the femora of the animals was measured quantitatively. A significant (p less than 0.001) reduction in bone mineral mass was found in the heparin-treated animals. This effect was present to the same degree after 33 days as after 65 days of treatment. It is concluded that heparin in this dose causes osteoporosis in rats after 33 days and that the described method can be used as an experimental model for further studies on this topic.},
  author       = {Mätzsch, Thomas and Bergqvist, D and Hedner, Ulla and Nilsson, B and Ostergaard, P},
  issn         = {0340-6245},
  language     = {eng},
  number       = {3},
  pages        = {293--294},
  publisher    = {F K Schattauer Verlag Gmbh},
  series       = {Thrombosis and Haemostasis},
  title        = {Heparin-induced osteoporosis in rats},
  volume       = {56},
  year         = {1986},
}