Muscarinic receptor density in the rat urinary bladder after denervation, hypertrophy and urinary diversion
(1986) In Acta Pharmacologica et Toxicologica 59(4). p.306-314- Abstract
- Parasympathetic denervation of the urinary bladder results in supersensitivity to muscarinic agonists and in bladder hypertrophy. In the present study, the effects of denervation on the muscarinic receptors in the rat bladder were investigated, using a receptor binding technique with (-)3H-QNB as radioligand. The density of muscarinic receptors was increased in denervated, hypertrophied bladders but it was decreased, below that in control bladders, when the development of hypertrophy was prevented by urinary diversion. A decreased receptor density was also found in innervated bladders after urinary diversion, whereas the receptor density was unaffected by hypertrophy alone. Competition experiments with methacholine revealed no changes in... (More)
- Parasympathetic denervation of the urinary bladder results in supersensitivity to muscarinic agonists and in bladder hypertrophy. In the present study, the effects of denervation on the muscarinic receptors in the rat bladder were investigated, using a receptor binding technique with (-)3H-QNB as radioligand. The density of muscarinic receptors was increased in denervated, hypertrophied bladders but it was decreased, below that in control bladders, when the development of hypertrophy was prevented by urinary diversion. A decreased receptor density was also found in innervated bladders after urinary diversion, whereas the receptor density was unaffected by hypertrophy alone. Competition experiments with methacholine revealed no changes in the agonist binding properties of the receptors. When the present data are combined with those in previous functional studies, it seems unlikely that the muscarinic receptors in the bladder are involved in the development of supersensitivity. It is suggested that the density of muscarinic receptors in the bladder may be related to the bladder function. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1103614
- author
- Nilvebrant, L ; Ekstrom, J and Malmberg, Lars LU
- organization
- publishing date
- 1986
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Pharmacologica et Toxicologica
- volume
- 59
- issue
- 4
- pages
- 306 - 314
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:3541495
- scopus:0022980367
- ISSN
- 0001-6683
- language
- English
- LU publication?
- yes
- id
- 99a5ecd3-b389-4cfb-9ab3-2b317e13ae8f (old id 1103614)
- date added to LUP
- 2016-04-01 15:40:56
- date last changed
- 2021-08-29 05:01:26
@article{99a5ecd3-b389-4cfb-9ab3-2b317e13ae8f, abstract = {{Parasympathetic denervation of the urinary bladder results in supersensitivity to muscarinic agonists and in bladder hypertrophy. In the present study, the effects of denervation on the muscarinic receptors in the rat bladder were investigated, using a receptor binding technique with (-)3H-QNB as radioligand. The density of muscarinic receptors was increased in denervated, hypertrophied bladders but it was decreased, below that in control bladders, when the development of hypertrophy was prevented by urinary diversion. A decreased receptor density was also found in innervated bladders after urinary diversion, whereas the receptor density was unaffected by hypertrophy alone. Competition experiments with methacholine revealed no changes in the agonist binding properties of the receptors. When the present data are combined with those in previous functional studies, it seems unlikely that the muscarinic receptors in the bladder are involved in the development of supersensitivity. It is suggested that the density of muscarinic receptors in the bladder may be related to the bladder function.}}, author = {{Nilvebrant, L and Ekstrom, J and Malmberg, Lars}}, issn = {{0001-6683}}, language = {{eng}}, number = {{4}}, pages = {{306--314}}, publisher = {{Wiley-Blackwell}}, series = {{Acta Pharmacologica et Toxicologica}}, title = {{Muscarinic receptor density in the rat urinary bladder after denervation, hypertrophy and urinary diversion}}, volume = {{59}}, year = {{1986}}, }