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Muscarinic receptor density in the rat urinary bladder after denervation, hypertrophy and urinary diversion

Nilvebrant, L; Ekstrom, J and Malmberg, Lars LU (1986) In Acta Pharmacologica et Toxicologica 59(4). p.306-314
Abstract
Parasympathetic denervation of the urinary bladder results in supersensitivity to muscarinic agonists and in bladder hypertrophy. In the present study, the effects of denervation on the muscarinic receptors in the rat bladder were investigated, using a receptor binding technique with (-)3H-QNB as radioligand. The density of muscarinic receptors was increased in denervated, hypertrophied bladders but it was decreased, below that in control bladders, when the development of hypertrophy was prevented by urinary diversion. A decreased receptor density was also found in innervated bladders after urinary diversion, whereas the receptor density was unaffected by hypertrophy alone. Competition experiments with methacholine revealed no changes in... (More)
Parasympathetic denervation of the urinary bladder results in supersensitivity to muscarinic agonists and in bladder hypertrophy. In the present study, the effects of denervation on the muscarinic receptors in the rat bladder were investigated, using a receptor binding technique with (-)3H-QNB as radioligand. The density of muscarinic receptors was increased in denervated, hypertrophied bladders but it was decreased, below that in control bladders, when the development of hypertrophy was prevented by urinary diversion. A decreased receptor density was also found in innervated bladders after urinary diversion, whereas the receptor density was unaffected by hypertrophy alone. Competition experiments with methacholine revealed no changes in the agonist binding properties of the receptors. When the present data are combined with those in previous functional studies, it seems unlikely that the muscarinic receptors in the bladder are involved in the development of supersensitivity. It is suggested that the density of muscarinic receptors in the bladder may be related to the bladder function. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Pharmacologica et Toxicologica
volume
59
issue
4
pages
306 - 314
publisher
Nordic Pharmacological Society
external identifiers
  • pmid:3541495
  • scopus:0022980367
ISSN
0001-6683
language
English
LU publication?
yes
id
99a5ecd3-b389-4cfb-9ab3-2b317e13ae8f (old id 1103614)
date added to LUP
2008-08-11 09:51:09
date last changed
2017-08-06 04:25:42
@article{99a5ecd3-b389-4cfb-9ab3-2b317e13ae8f,
  abstract     = {Parasympathetic denervation of the urinary bladder results in supersensitivity to muscarinic agonists and in bladder hypertrophy. In the present study, the effects of denervation on the muscarinic receptors in the rat bladder were investigated, using a receptor binding technique with (-)3H-QNB as radioligand. The density of muscarinic receptors was increased in denervated, hypertrophied bladders but it was decreased, below that in control bladders, when the development of hypertrophy was prevented by urinary diversion. A decreased receptor density was also found in innervated bladders after urinary diversion, whereas the receptor density was unaffected by hypertrophy alone. Competition experiments with methacholine revealed no changes in the agonist binding properties of the receptors. When the present data are combined with those in previous functional studies, it seems unlikely that the muscarinic receptors in the bladder are involved in the development of supersensitivity. It is suggested that the density of muscarinic receptors in the bladder may be related to the bladder function.},
  author       = {Nilvebrant, L and Ekstrom, J and Malmberg, Lars},
  issn         = {0001-6683},
  language     = {eng},
  number       = {4},
  pages        = {306--314},
  publisher    = {Nordic Pharmacological Society},
  series       = {Acta Pharmacologica et Toxicologica},
  title        = {Muscarinic receptor density in the rat urinary bladder after denervation, hypertrophy and urinary diversion},
  volume       = {59},
  year         = {1986},
}